دورية أكاديمية
Pretreatment asthma control test score as a predictive score for clinical remission after bronchial thermoplasty in younger patients with severe asthma and preserved lung function.
| العنوان: | Pretreatment asthma control test score as a predictive score for clinical remission after bronchial thermoplasty in younger patients with severe asthma and preserved lung function. |
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| المؤلفون: | Kashizaki F; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan.; Department of Respiratory Medicine, Seirei Yokohama Hospital, Yokohama, Japan., Konishi K; Department of Respiratory Medicine, Seirei Yokohama Hospital, Yokohama, Japan., Chen H; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Tanaka A; Department of Respiratory Medicine, Isehara Kyodo Hospital, Isehara, Japan., Miyasaka A; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Okazaki S; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Yamada C; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Tsuchiya N; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Yumoto K; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Koizumi H; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Takahashi K; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Kaneko T; Department of Respiratory Medicine, Yokohama City University Hospital, Yokohama, Japan. |
| المصدر: | The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Jul; Vol. 61 (7), pp. 663-670. Date of Electronic Publication: 2024 Jan 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8106454 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4303 (Electronic) Linking ISSN: 02770903 NLM ISO Abbreviation: J Asthma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Ossining, N.Y. : Asthma Publications Society, c1981- |
| مواضيع طبية MeSH: | Asthma*/therapy , Asthma*/physiopathology , Bronchial Thermoplasty*/methods , Respiratory Function Tests*, Humans ; Male ; Adult ; Female ; Middle Aged ; Severity of Illness Index ; Remission Induction ; Forced Expiratory Volume ; Treatment Outcome ; Lung/physiopathology |
| مستخلص: | Objective: Bronchial thermoplasty (BT) decreases the incidence of asthma exacerbations, emergency room visits, and hospitalizations among patients with severe asthma. Predictors of BT effectiveness remain unclear as its mechanism of action and invasiveness remain obscure. This study aimed to identify factors that could predict BT outcomes. Methods: Two respiratory physicians treated 20 consecutive patients with severe asthma using BT. The patients were assigned to groups based on clinical remission following an expert consensus proposed in 2020. Predictors of clinical remission were analyzed using asthma control test (ACT) score, pulmonary function and blood tests, and fractional exhaled nitric oxide. Results: At baseline, the median age was 44 years (interquartile range [IQR], 31.0-52.8), and pre-bronchodilator (pre-BD) percent predicted forced expiratory volume in one second (%FEV1) was 85.9% (IQR, 74.8-100.5). Six (30%) patients achieved clinical remission. Among the patients treated with biologics, 20% had clinical remission, and 20% discontinued biologic therapy. The pre-BT ACT score was significantly lower in the group with than without remission (11.0 [IQR, 8.0-14.5] vs. 15.0 [IQR, 11.0-17.3], p = .016). Adverse events did not significantly differ between the groups. Conclusions: To the best of our knowledge, this is the first study to use clinical remission as a criterion for evaluating BT efficacy. The pre-BT ACT score might a the predict response to BT in younger adult patients with severe asthma and pre-BD %FEV1 ≥ 70%. |
| فهرسة مساهمة: | Keywords: Asthma control test; biologic; bronchial thermoplasty; clinical remission; percent predicted forced expiratory volume in one second |
| تواريخ الأحداث: | Date Created: 20240102 Date Completed: 20240611 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| DOI: | 10.1080/02770903.2023.2297375 |
| PMID: | 38163925 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1532-4303 |
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| DOI: | 10.1080/02770903.2023.2297375 |