دورية أكاديمية
أعرض في EDS

Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.

التفاصيل البيبلوغرافية
العنوان: Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.
المؤلفون: Wu JH; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA., Moghimi S; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA., Walker E; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA., Nishida T; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA., Liebmann JM; Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S Harkness Eye Institute, Columbia University Medical Center, New York, New York, USA., Fazio MA; Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA., Girkin CA; Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA., Zangwill LM; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA., Weinreb RN; Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA rweinreb@ucsd.edu.
المصدر: The British journal of ophthalmology [Br J Ophthalmol] 2024 Jul 23; Vol. 108 (8), pp. 1094-1100. Date of Electronic Publication: 2024 Jul 23.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 1992- : London : BMJ Pub. Group
Original Publication: 1917-Dec. 1991: London : British Medical Association
مواضيع طبية MeSH: Glaucoma*/ethnology , Glaucoma*/physiopathology , Glaucoma*/diagnosis , Intraocular Pressure*/physiology , Nerve Fibers*/pathology , Optic Disk*/pathology , Optic Disk*/diagnostic imaging , Retinal Ganglion Cells*/pathology, Aged ; Female ; Humans ; Male ; Middle Aged ; Black People ; Follow-Up Studies ; Glaucoma, Open-Angle/physiopathology ; Glaucoma, Open-Angle/ethnology ; Glaucoma, Open-Angle/diagnosis ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Visual Fields/physiology ; White People/ethnology
مستخلص: Background: To examine long-term retinal nerve fibre layer thickness (RNFLT) variability and associated clinical factors in African (AD) and European descent (ED) individuals with glaucoma.
Methods: This retrospective cohort study included glaucoma eyes of AD and ED from Diagnostic Innovations in Glaucoma Study/The African Descent and Glaucoma Evaluation Study with ≥4 visits/2 years of follow-up. We calculated optic nerve head RNFLT variability per-examination/visit as the absolute error of its residuals across follow-up. Full, baseline and parsimonious linear-mixed models were fit to evaluate the effects of clinical factors (demographics and ocular characteristics, prior/intervening glaucoma surgeries and cataract extraction (CE), RNFLT thinning rate, scan quality, visit/testing frequency, etc) on RNFLT variability in both races.
Results: There were 376 and 625 eyes (226 and 349 participants) of AD and ED, and the mean (95% CI) RNFLT variability was 1.62 (1.52, 1.71) µm and 1.42 (1.34, 1.50) µm, respectively (p=0.002). AD and ED had some shared predictors of RNFLT variability, including intraocular pressure fluctuation and scan quality, although the effects varied (p<0.05). In both races, intervening CE was most strongly correlated with higher RNFLT variability (β: 0.24-0.92, p<0.05). After excluding eyes with intervening CE, RNFLT variability was reduced and the small racial difference was no longer significant (AD: 1.40 (1.31, 1.48) µm vs ED: 1.34 (1.27, 1.40) µm; p=0.280).
Conclusions: Although some predictors were identified, long-term RNFLT variability appeared small for both AD and ED eyes. Moreover, the racial difference did not remain once intervening CE, the strongest predictor of variability, was eliminated. Our findings inform on strategies to optimise structural assessment and suggest that, when accounting for relevant factors, RNFLT is reliable across races.
Competing Interests: Competing interests: SM reported grants from the National Eye Institute. TN is a consultant for Topcon. JML is a consultant to Alcon, Genetech, Thea, Allergan, Carl Zeiss Meditech and AdvanceSight. MAF reported grants from the National Eye Institute, Topcon and Heidelberg Engineering; and non-financial support from Wolfram Research. CAG reported research support from Topcon and Heidelberg Engineering. LMZ reported grants from the National Eye Institute and Heidelberg Engineering; non-financial support from Optovue, Heidelberg Engineering, Carl Zeiss Meditec and Topcon; and patents to AiSight Health and Carl Zeiss Meditec. LMZ is a consultant of AbbVie and Topcon. RNW is a consultant of AbbVie, Equinox Alcon, Allergan, Eyenovia, Iantrek, Amydis, IOPtic, Nicox, Santen, Implandata and Topcon. RNW reported non-financial support from Carl Zeiss Meditec, Optovue, Heidelberg Engineering, Topcon and Centervue; grants from the National Institute of Minority Health Disparities, National Eye Institute and Research to Prevent Blindness; and patents from Toromedes, Carl Zeiss Meditec to UCSD, all outside the submitted work.
(© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
References: Sci Rep. 2022 Jul 15;12(1):12109. (PMID: 35840610)
Br J Ophthalmol. 2023 May;107(5):657-662. (PMID: 34933897)
Ophthalmology. 1989 May;96(5):579-84. (PMID: 2748112)
J Glaucoma. 2017 Oct;26(10):851-859. (PMID: 28858159)
JAMA Ophthalmol. 2022 Dec 1;140(12):1209-1216. (PMID: 36301523)
Arch Ophthalmol. 2005 Dec;123(12):1693-8. (PMID: 16344441)
Eye (Lond). 2019 Dec;33(12):1833-1841. (PMID: 31227788)
J Glaucoma. 2012 Apr-May;21(4):266-73. (PMID: 21637116)
Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5912-20. (PMID: 22871835)
Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):8. (PMID: 33151281)
Clin Exp Ophthalmol. 2002 Jun;30(3):159-62. (PMID: 12010205)
Turk J Emerg Med. 2018 Aug 07;18(3):91-93. (PMID: 30191186)
Curr Opin Ophthalmol. 2019 Jan;30(1):56-62. (PMID: 30489361)
Clin Ophthalmol. 2018 Dec 18;13:9-16. (PMID: 30587914)
Ophthalmology. 2017 Dec;124(12S):S57-S65. (PMID: 29157363)
Ophthalmology. 2019 Jul;126(7):980-988. (PMID: 30858023)
Invest Ophthalmol Vis Sci. 2011 May 18;52(6):3338-44. (PMID: 21330656)
Invest Ophthalmol Vis Sci. 2011 Aug 03;52(9):6148-53. (PMID: 21421879)
Br J Ophthalmol. 2006 Oct;90(10):1259-62. (PMID: 16980644)
Invest Ophthalmol Vis Sci. 2011 May 17;52(6):3237-45. (PMID: 21357405)
Am J Ophthalmol. 2018 Dec;196:154-164. (PMID: 30195890)
Arch Ophthalmol. 2010 May;128(5):541-50. (PMID: 20457974)
JAMA Ophthalmol. 2018 Apr 1;136(4):329-335. (PMID: 29450497)
Ophthalmology. 2021 Jul;128(7):1005-1015. (PMID: 33217471)
Arch Ophthalmol. 2009 Sep;127(9):1136-45. (PMID: 19752422)
J Glaucoma. 2011 Oct;20(8):470-6. (PMID: 20852437)
Br J Ophthalmol. 2014 Oct;98(10):1315-9. (PMID: 24627247)
J Glaucoma. 2011 Jan;20(1):37-43. (PMID: 20179622)
Am J Ophthalmol. 2010 Mar;149(3):496-502.e1. (PMID: 20042179)
Exp Eye Res. 2018 Apr;169:79-90. (PMID: 29409880)
Transl Vis Sci Technol. 2018 Nov 27;7(6):12. (PMID: 30510856)
N Engl J Med. 1991 Nov 14;325(20):1412-7. (PMID: 1922252)
Am J Ophthalmol. 2015 Apr;159(4):777-87. (PMID: 25597839)
Ophthalmology. 2023 Jan;130(1):39-47. (PMID: 35932839)
Ophthalmology. 2020 Jun;127(6):739-747. (PMID: 31952885)
Am J Ophthalmol. 2023 Nov;255:98-106. (PMID: 37454784)
Ophthalmology. 2023 Jun;130(6):631-639. (PMID: 36754173)
معلومات مُعتمدة: R01 EY011008 United States EY NEI NIH HHS; R01 EY029058 United States EY NEI NIH HHS; P30 EY022589 United States EY NEI NIH HHS; R01 EY019869 United States EY NEI NIH HHS; R01 EY027510 United States EY NEI NIH HHS; R01 EY026574 United States EY NEI NIH HHS; R01 EY018926 United States EY NEI NIH HHS; R01 EY034148 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: glaucoma
تواريخ الأحداث: Date Created: 20240102 Date Completed: 20240723 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11153332
DOI: 10.1136/bjo-2023-324404
PMID: 38164556
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-2079
DOI:10.1136/bjo-2023-324404