دورية أكاديمية
Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids.
| العنوان: | Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids. |
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| المؤلفون: | Hofford RS; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Meckel KR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Wiser EJ; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101., Wang W; Keck MS & Proteomics Resource, Yale University School of Medicine, New Haven, CT 06520., Sens JP; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101., Kim M; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Godino A; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Lam TT; Keck MS & Proteomics Resource, Yale University School of Medicine, New Haven, CT 06520.; Yale/NIDA Neuroproteomics Center, Yale University School of Medicine, New Haven, CT 06520.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520., Kiraly DD; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101 dkiraly@wakehealth.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Department of Psychiatry, Atrium Health Wake Forest Baptist, Winston-Salem, NC 27101. |
| المصدر: | ENeuro [eNeuro] 2024 Feb 15; Vol. 11 (2). Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Washington, DC] : Society for Neuroscience, [2014]- |
| مواضيع طبية MeSH: | Opioid-Related Disorders*/drug therapy , Gastrointestinal Microbiome*, Male ; Rats ; Animals ; Fentanyl ; Proteome ; Proteomics ; Analgesics, Opioid |
| مستخلص: | Opioid use disorder (OUD) is a public health crisis currently being exacerbated by increased rates of use and overdose of synthetic opioids, primarily fentanyl. Therefore, the identification of novel biomarkers and treatment strategies to reduce problematic fentanyl use and relapse to fentanyl taking is critical. In recent years, there has been a growing body of work demonstrating that the gut microbiome can serve as a potent modulator of the behavioral and transcriptional responses to both stimulants and opioids. Here, we advance this work to define how manipulations of the microbiome drive fentanyl intake and fentanyl-seeking in a translationally relevant drug self-administration model. Depletion of the microbiome of male rats with broad spectrum antibiotics leads to increased drug administration on increased fixed ratio, progressive ratio, and drug seeking after abstinence. Utilizing 16S sequencing of microbiome contents from these animals, specific populations of bacteria from the gut microbiome correlate closely with levels of drug taking. Additionally, global proteomic analysis of the nucleus accumbens following microbiome manipulation and fentanyl administration to define how microbiome status alters the functional proteomic landscape in this key limbic substructure. These data demonstrate that an altered microbiome leads to marked changes in the synaptic proteome in response to repeated fentanyl treatment. Finally, behavioral effects of microbiome depletion are reversible by upplementation of the microbiome derived short-chain fatty acid metabolites. Taken together, these findings establish clear relevance for gut-brain signaling in models of OUD and lay foundations for further translational work in this space. (Copyright © 2024 Hofford et al.) |
| References: | Mol Psychiatry. 2022 Jun;27(6):2868-2878. (PMID: 35296806) Semin Cancer Biol. 2006 Aug;16(4):318-30. (PMID: 16934487) Mol Neurobiol. 2021 Aug;58(8):4169-4177. (PMID: 33954904) Psychopharmacology (Berl). 2016 Jun;233(11):2015-2024. (PMID: 25066361) Neuropsychobiology. 2020;79(1):50-62. (PMID: 31726457) J Neurosci. 2021 Feb 17;41(7):1553-1565. (PMID: 33361463) Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13523-13532. (PMID: 31209039) Environ Microbiol. 2017 Jan;19(1):29-41. (PMID: 27928878) Semin Cancer Biol. 2006 Aug;16(4):253-64. (PMID: 16904903) Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552. (PMID: 34723319) Sci Rep. 2016 Oct 18;6:35455. (PMID: 27752130) Psychopharmacology (Berl). 2019 May;236(5):1513-1530. (PMID: 30982128) Pharmacol Rev. 2022 Jan;74(1):119-140. (PMID: 34987089) Nat Rev Cancer. 2002 Oct;2(10):764-76. (PMID: 12360279) Int J Drug Policy. 2019 Aug;70:40-46. (PMID: 31079029) Front Neuroendocrinol. 2020 Jan;56:100815. (PMID: 31805290) Sci Rep. 2017 Feb 17;7:42658. (PMID: 28211545) Neuroscience. 1996 Feb;70(3):749-54. (PMID: 9045086) Neuropsychopharmacology. 2024 Jan;49(2):386-395. (PMID: 37528220) BMC Genomics. 2008 Oct 16;9:488. (PMID: 18925949) Sci Rep. 2018 Feb 26;8(1):3596. (PMID: 29483538) BMC Bioinformatics. 2013 Apr 15;14:128. (PMID: 23586463) Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478. (PMID: 31123355) eNeuro. 2020 May 21;7(3):. (PMID: 32341122) Nature. 2019 Oct;574(7779):543-548. (PMID: 31645720) Nucleic Acids Res. 2019 Jul 2;47(W1):W191-W198. (PMID: 31066453) Transl Psychiatry. 2016 Apr 05;6:e774. (PMID: 27045844) Neuropsychopharmacology. 2021 Nov;46(12):2062-2072. (PMID: 34127799) Neuron. 2019 Apr 3;102(1):48-59. (PMID: 30946825) Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9167-72. (PMID: 22615378) Cell. 2018 Jan 25;172(3):500-516.e16. (PMID: 29275859) Mol Cell Neurosci. 2023 Sep;126:103874. (PMID: 37315877) Nat Neurosci. 2015 Jul;18(7):965-77. (PMID: 26030851) Neuropsychopharmacology. 2018 Dec;43(13):2606-2614. (PMID: 30258112) Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:36-46. (PMID: 24184686) Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110058. (PMID: 32791167) Biol Sex Differ. 2022 Mar 25;13(1):12. (PMID: 35337376) Neurosci Lett. 2011 Nov 14;505(2):124-7. (PMID: 22005580) Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243) Front Neuroendocrinol. 2021 Apr;61:100912. (PMID: 33713673) J Neurosci Methods. 1996 May;66(1):1-11. (PMID: 8794935) Brain Res Mol Brain Res. 2000 May 5;77(2):270-6. (PMID: 10837922) Neuropharmacology. 2021 Jul 1;192:108598. (PMID: 33965398) Brain Res Mol Brain Res. 2001 Jun 20;90(2):202-4. (PMID: 11406298) Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7. (PMID: 27141961) Mol Psychiatry. 2018 May;23(5):1134-1144. (PMID: 28507320) |
| معلومات مُعتمدة: | K01 DA050906 United States DA NIDA NIH HHS; P30 DA018343 United States DA NIDA NIH HHS; S10 OD019967 United States OD NIH HHS; F99 NS124187 United States NS NINDS NIH HHS; DP1 DA051551 United States DA NIDA NIH HHS; R01 DA056592 United States DA NIDA NIH HHS |
| فهرسة مساهمة: | Keywords: fentanyl; microbiome; proteomics; self-administration |
| المشرفين على المادة: | UF599785JZ (Fentanyl) 0 (Proteome) 0 (Analgesics, Opioid) |
| تواريخ الأحداث: | Date Created: 20240102 Date Completed: 20240219 Latest Revision: 20240511 |
| رمز التحديث: | 20240511 |
| مُعرف محوري في PubMed: | PMC10875718 |
| DOI: | 10.1523/ENEURO.0388-23.2023 |
| PMID: | 38164564 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2373-2822 |
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| DOI: | 10.1523/ENEURO.0388-23.2023 |