دورية أكاديمية
أعرض في EDS

Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.

التفاصيل البيبلوغرافية
العنوان: Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.
المؤلفون: Schmidt BM; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Keeney-Bonthrone TP; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Hawes AM; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Karmakar M; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Frydrych LM; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Cinti SK; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Pop-Busui R; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Delano MJ; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA mjdelano@med.umich.edu.; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
المصدر: BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2023 Dec 12; Vol. 11 (6). Date of Electronic Publication: 2023 Dec 12.
نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Published by BMJ in partnership with the American Diabetes Association Country of Publication: England NLM ID: 101641391 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4897 (Electronic) Linking ISSN: 20524897 NLM ISO Abbreviation: BMJ Open Diabetes Res Care Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Published by BMJ in partnership with the American Diabetes Association
مواضيع طبية MeSH: Diabetic Foot*/diagnosis , Osteomyelitis*/complications , Osteomyelitis*/epidemiology , Osteomyelitis*/surgery , Peripheral Vascular Diseases*/complications, Humans ; Male ; Amputation, Surgical ; Extremities/surgery ; Incidence ; Female
مستخلص: Introduction: Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with osteomyelitis over 2 years.
Research Design and Methods: Observational cohort study of 1186 inpatients with osteomyelitis between 2004 and 2015 and stratified by osteomyelitis location status to evaluate the impact on amputation, mortality rates, readmission data, and inpatient days.
Results: Persons with diabetes had 3.65 times greater probability of lower extremity amputation (p<0.001), readmission (p<0.001), and longer inpatient stay (p<0.001) and had higher 2-year mortality (relative risk (RR) 1.23, p=0.0027), adjusting for risk factors. Male gender (RR 1.57, p<0.001), black race (RR 1.41, p<0.05), former smoking status (RR 1.38, p<0.01), myocardial infarction (RR 1.72, p<0.001), congestive heart failure (RR 1.56, p<0.001), peripheral vascular disease (RR 2.25, p<0.001) and renal disease (RR 1.756, p<0.001) were independently associated with amputation. Male gender (RR 1.39, p<0.01), black race (RR 1.27, p<0.05), diabetes (RR 2.77, p<0.001) and peripheral vascular disease (RR 1.59, p<0.001) had increased risk of lower, not upper, extremity amputation.
Conclusions: Patients with osteomyelitis have higher rates of amputation and hospitalization. Clinicians must incorporate demographic and comorbid risk factors to protect against amputation.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
References: Nature. 2001 Dec 13;414(6865):782-7. (PMID: 11742409)
Diabetes Care. 2000 Sep;23(9):1333-8. (PMID: 10977028)
Clin Infect Dis. 2004 Oct 1;39(7):885-910. (PMID: 15472838)
N Engl J Med. 2007 Jan 18;356(3):213-5. (PMID: 17229948)
N Engl J Med. 2017 Apr 13;376(15):1419-1429. (PMID: 28402773)
Diabetes Res Clin Pract. 2009 Mar;83(3):347-52. (PMID: 19117631)
Clin Infect Dis. 2004 Aug 1;39 Suppl 2:S115-22. (PMID: 15306989)
Am J Epidemiol. 2004 Apr 1;159(7):702-6. (PMID: 15033648)
Patient Saf Surg. 2017 Jun 2;11:17. (PMID: 28588645)
Cardiovasc Diabetol. 2015 Dec 18;14:152. (PMID: 26684912)
Pan Afr Med J. 2014 Oct 20;19:170. (PMID: 25810806)
Lancet. 2017 Jan 7;389(10064):37-55. (PMID: 27863813)
J Biomed Inform. 2015 Jun;55:290-300. (PMID: 25979153)
Ther Adv Endocrinol Metab. 2013 Jun;4(3):83-94. (PMID: 23730502)
Diabetes Care. 2004 May;27(5):1047-53. (PMID: 15111519)
Clin Infect Dis. 2008 Aug 15;47(4):519-27. (PMID: 18611152)
Clin Infect Dis. 2012 Jun;54(12):e132-73. (PMID: 22619242)
Clin Orthop Relat Res. 1993 Oct;(295):28-36. (PMID: 8403662)
J Antimicrob Chemother. 2003 May;51(5):1261-8. (PMID: 12668581)
Strategies Trauma Limb Reconstr. 2016 Aug;11(2):135-42. (PMID: 27369868)
JAMA Intern Med. 2018 Aug 1;178(8):1025-1032. (PMID: 29987332)
J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716)
Clin Infect Dis. 2016 Oct 1;63(7):944-8. (PMID: 27369321)
J Vasc Surg. 2015 Mar;61(3 Suppl):2S-41S. (PMID: 25638515)
J Diabetes Complications. 2005 Mar-Apr;19(2):107-12. (PMID: 15745841)
J Bone Joint Surg Am. 2015 May 20;97(10):837-45. (PMID: 25995495)
Foot Ankle Clin. 2014 Sep;19(3):569-88. (PMID: 25129362)
J Vasc Surg. 2008 May;47(5):1001-7; discussion 1007. (PMID: 18358670)
Curr Med Res Opin. 2015 May;31(5):913-23. (PMID: 25772230)
Arch Intern Med. 2007 Jan 22;167(2):125-32. (PMID: 17242312)
Bull NYU Hosp Jt Dis. 2009;67(4):313-7. (PMID: 20001930)
J Foot Ankle Res. 2010 Nov 24;3:27. (PMID: 21106076)
J Zhejiang Univ Sci B. 2014 Jan;15(1):58-66. (PMID: 24390745)
BMC Med Res Methodol. 2016 Nov 22;16(1):160. (PMID: 27876006)
Diabetes Metab. 2011 Jun;37(3):208-15. (PMID: 21169044)
J Clin Epidemiol. 1994 Nov;47(11):1245-51. (PMID: 7722560)
معلومات مُعتمدة: K23 DK131261 United States DK NIDDK NIH HHS; R01 DK107956 United States DK NIDDK NIH HHS; U01 DK119083 United States DK NIDDK NIH HHS; K23 DK116720 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Diabetes Complications; Diabetic Foot; Limb Salvage; Osteomyelitis
تواريخ الأحداث: Date Created: 20240102 Date Completed: 20240116 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10729224
DOI: 10.1136/bmjdrc-2023-003611
PMID: 38164707
قاعدة البيانات: MEDLINE
الوصف
تدمد:2052-4897
DOI:10.1136/bmjdrc-2023-003611