دورية أكاديمية
Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation.
العنوان: | Comorbid status in patients with osteomyelitis is associated with long-term incidence of extremity amputation. |
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المؤلفون: | Schmidt BM; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Keeney-Bonthrone TP; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Hawes AM; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Karmakar M; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Frydrych LM; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Cinti SK; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Pop-Busui R; Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA., Delano MJ; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA mjdelano@med.umich.edu.; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA. |
المصدر: | BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2023 Dec 12; Vol. 11 (6). Date of Electronic Publication: 2023 Dec 12. |
نوع المنشور: | Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Published by BMJ in partnership with the American Diabetes Association Country of Publication: England NLM ID: 101641391 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4897 (Electronic) Linking ISSN: 20524897 NLM ISO Abbreviation: BMJ Open Diabetes Res Care Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Published by BMJ in partnership with the American Diabetes Association |
مواضيع طبية MeSH: | Diabetic Foot*/diagnosis , Osteomyelitis*/complications , Osteomyelitis*/epidemiology , Osteomyelitis*/surgery , Peripheral Vascular Diseases*/complications, Humans ; Male ; Amputation, Surgical ; Extremities/surgery ; Incidence ; Female |
مستخلص: | Introduction: Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with osteomyelitis over 2 years. Research Design and Methods: Observational cohort study of 1186 inpatients with osteomyelitis between 2004 and 2015 and stratified by osteomyelitis location status to evaluate the impact on amputation, mortality rates, readmission data, and inpatient days. Results: Persons with diabetes had 3.65 times greater probability of lower extremity amputation (p<0.001), readmission (p<0.001), and longer inpatient stay (p<0.001) and had higher 2-year mortality (relative risk (RR) 1.23, p=0.0027), adjusting for risk factors. Male gender (RR 1.57, p<0.001), black race (RR 1.41, p<0.05), former smoking status (RR 1.38, p<0.01), myocardial infarction (RR 1.72, p<0.001), congestive heart failure (RR 1.56, p<0.001), peripheral vascular disease (RR 2.25, p<0.001) and renal disease (RR 1.756, p<0.001) were independently associated with amputation. Male gender (RR 1.39, p<0.01), black race (RR 1.27, p<0.05), diabetes (RR 2.77, p<0.001) and peripheral vascular disease (RR 1.59, p<0.001) had increased risk of lower, not upper, extremity amputation. Conclusions: Patients with osteomyelitis have higher rates of amputation and hospitalization. Clinicians must incorporate demographic and comorbid risk factors to protect against amputation. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
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معلومات مُعتمدة: | K23 DK131261 United States DK NIDDK NIH HHS; R01 DK107956 United States DK NIDDK NIH HHS; U01 DK119083 United States DK NIDDK NIH HHS; K23 DK116720 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: Diabetes Complications; Diabetic Foot; Limb Salvage; Osteomyelitis |
تواريخ الأحداث: | Date Created: 20240102 Date Completed: 20240116 Latest Revision: 20240210 |
رمز التحديث: | 20240210 |
مُعرف محوري في PubMed: | PMC10729224 |
DOI: | 10.1136/bmjdrc-2023-003611 |
PMID: | 38164707 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2052-4897 |
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DOI: | 10.1136/bmjdrc-2023-003611 |