دورية أكاديمية
Thyroid cartilage infiltration in advanced laryngeal cancer: prognostic implications and predictive modelling.
| العنوان: | Thyroid cartilage infiltration in advanced laryngeal cancer: prognostic implications and predictive modelling. |
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| المؤلفون: | Montenegro C; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Paderno A; Unit of Otorhinolaryngology, IRCCS Humanitas Research Hospital, Milan, Italy., Ravanelli M; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy.; Unit of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Pessina C; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy.; Unit of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Nassih FE; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Lancini D; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Del Bon F; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Mattavelli D; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Farina D; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy.; Unit of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy., Piazza C; Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, School of Medicine, Brescia, Italy. |
| المصدر: | Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale [Acta Otorhinolaryngol Ital] 2024 Jun; Vol. 44 (3), pp. 176-182. Date of Electronic Publication: 2023 Dec 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pacini editore Country of Publication: Italy NLM ID: 8213019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1827-675X (Electronic) Linking ISSN: 0392100X NLM ISO Abbreviation: Acta Otorhinolaryngol Ital Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Pisa : Pacini editore, 1981- |
| مواضيع طبية MeSH: | Laryngeal Neoplasms*/pathology , Laryngeal Neoplasms*/mortality , Laryngeal Neoplasms*/surgery , Thyroid Cartilage*/pathology , Neoplasm Invasiveness*, Humans ; Male ; Retrospective Studies ; Female ; Prognosis ; Aged ; Middle Aged ; Aged, 80 and over ; Adult ; Neoplasm Staging ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/surgery |
| مستخلص: | Objective: Detection of laryngeal cartilage invasion is of great importance in staging of laryngeal squamous cell carcinoma (LSCC). The role of prognosticators in locally advanced laryngeal cancer are still widely debated. This study aimed to assess the impact of volume of thyroid cartilage infiltration, as well as other histopathologic variables, on patient survival. Materials and Methods: We retrospectively analysed 74 patients affected by pT4 LSCC and treated with total laryngectomy between 2005 and 2021 at the Department of Otorhinolaryngology - Head and Neck Surgery of the University of Brescia, Italy. We considered as potential prognosticators histological grade, perineural (PNI) and lympho-vascular invasion (LVI), thyroid cartilage infiltration, and pTN staging. Pre-operative CT or MRI were analysed to quantify the volume of cartilage infiltration using 3D Slicer software. Results: The 1-, 3-, and 5-year disease free survivals (DFS) were 76%, 66%, and 64%, respectively. Using machine learning models, we found that the volume of thyroid cartilage infiltration had high correlation with DFS. Patients with a higher volume (>670 mm 3 ) of infiltration had a worse prognosis compared to those with a lower volume. Conclusions: Our study confirms the essential role of LVI as prognosticator in advanced LSCC and, more innovatively, highlights the volume of thyroid cartilage infiltration as another promising prognostic factor. (Copyright © 2024 Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy.) |
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| فهرسة مساهمة: | Keywords: cartilage infiltration; laryngeal cancer; machine learning; predictive model; prognostic factors; thyroid cartilage |
| تواريخ الأحداث: | Date Created: 20240102 Date Completed: 20240611 Latest Revision: 20240613 |
| رمز التحديث: | 20240613 |
| مُعرف محوري في PubMed: | PMC11166214 |
| DOI: | 10.14639/0392-100X-N2739 |
| PMID: | 38165207 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1827-675X |
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| DOI: | 10.14639/0392-100X-N2739 |