دورية أكاديمية
A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria.
| العنوان: | A systematic review and meta-analysis of efficacy and safety of compound glycyrrhizin combined with second-generation non-sedated antihistamine for the treatment of chronic urticaria. |
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| المؤلفون: | Chen S; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Cao W; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Xiao X; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Wang L; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Wan R; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Zou Z; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Yang Q; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li Y; Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, China. |
| المصدر: | The Journal of dermatological treatment [J Dermatolog Treat] 2024 Dec; Vol. 35 (1), pp. 2299597. Date of Electronic Publication: 2024 Jan 03. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Houndmills, Basingstoke, Hampshire, UK : M. Dunitz and Macmillan Press, [c1989]- |
| مواضيع طبية MeSH: | Chronic Urticaria*/drug therapy , Glycyrrhizic Acid*/adverse effects , Glycyrrhizic Acid*/therapeutic use , Histamine H1 Antagonists, Non-Sedating*/adverse effects , Histamine H1 Antagonists, Non-Sedating*/therapeutic use, Humans ; Chronic Disease ; Histamine Antagonists/adverse effects ; Histamine Antagonists/therapeutic use ; Histamine H1 Antagonists/adverse effects ; Histamine H1 Antagonists/therapeutic use |
| مستخلص: | Background: Chronic urticaria (CU) is a prevalent dermatologic disease that negatively affects life, current therapies remain suboptimal. Hence, there is an urgent need to identify effective and safe treatment. Objective: Assess the efficacy and safety of compound glycyrrhizin (CG) combined with second-generation nonsedated antihistamine for the treatment of CU. Methods: Nine databases were queried to screen RCTs related. Two reviewers independently assessed the risk of bias using Cochrane Collaboration. Primary objective was the total efficiency rate, while secondary was rate of recurrence, adverse events, and cure. Statistical analyses using Review Manager 5.4 and Stata17. Results: Twenty-four RCTs were identified. Significant differences were noted in rate of total efficiency ( n = 2649, RR = 1.36, 95%CI:1.30-1.43, p < 0.00001), cure ( n = 2649, RR = 1.54, 95%CI:1.42-1.66, p < 0.00001) and recurrence ( n = 446, RR = 0.34, 95%CI:0.20-0.58, p < 0.00001) between the combination of CG with second-generation non-sedated antihistamine and antihistamine monotherapy. Contrastingly, adverse events rate ( n = 2317, RR = 0.76, 95% CI:0.59-0.97, p = 0.03) was comparable between the two groups. Our results indicated that CG combined with second-generation non-sedated antihistamine could significantly mitigate the symptoms in CU compared with antihistamine monotherapy. No serious adverse events were reported. Conclusions: CG combined with second-generation nonsedated antihistamine is effective for CU. Nevertheless, higher-quality studies are warranted to validate our results. |
| فهرسة مساهمة: | Keywords: Chronic urticaria; antihistamine. meta-analysis; compound glycyrrhizin capsule; compound glycyrrhizin injection; compound glycyrrhizin tablet |
| المشرفين على المادة: | 6FO62043WK (Glycyrrhizic Acid) 0 (Histamine Antagonists) 0 (Histamine H1 Antagonists) 0 (Histamine H1 Antagonists, Non-Sedating) |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240104 Latest Revision: 20240104 |
| رمز التحديث: | 20240104 |
| DOI: | 10.1080/09546634.2023.2299597 |
| PMID: | 38166511 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1471-1753 |
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| DOI: | 10.1080/09546634.2023.2299597 |