دورية أكاديمية
أعرض في EDS

Evening primrose oil enriched with gamma linolenic acid and D/L-alpha tocopherol acetate attenuated carbon tetrachloride-induced hepatic injury model in male rats via TNF-α, IL-1β, and IL-6 pathway.

التفاصيل البيبلوغرافية
العنوان: Evening primrose oil enriched with gamma linolenic acid and D/L-alpha tocopherol acetate attenuated carbon tetrachloride-induced hepatic injury model in male rats via TNF-α, IL-1β, and IL-6 pathway.
المؤلفون: Gad El-Hak HN; Zoology Department, Faculty of Sciences, Suez Canal University, Ismailia, Egypt., Kishk SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Abdelrazek HMA; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
المصدر: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 Jun; Vol. 34 (5), pp. 469-483. Date of Electronic Publication: 2024 Jan 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: London : Taylor and Francis, c2002-
مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/drug therapy , Plant Oils*/pharmacology , Plant Oils*/chemistry , Liver*/drug effects , Liver*/metabolism , Liver*/pathology , Liver*/ultrastructure , gamma-Linolenic Acid*/pharmacology , Oenothera biennis*/chemistry, Animals ; Male ; Interleukin-1beta/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Oxidative Stress/drug effects ; Molecular Docking Simulation ; Carbon Tetrachloride/toxicity ; Interleukin-6/metabolism ; Rats ; Linoleic Acids/pharmacology ; Antioxidants/pharmacology ; Rats, Wistar ; Signal Transduction/drug effects ; Disease Models, Animal
مستخلص: The modulatory role of primrose oil (PO) supplementation enriched with γ-linolenic acid and D/L-alpha tocopherol acetate against a carbon tetrachloride (CCl 4 )-induced liver damage model was assessed in this study. Twenty male Albino rats were divided into four groups. The control group received corn oil orally. The PO group received 10 mg/kg P O orally. The CCl 4 group received 2 mL/kg CCl 4 orally and PO/CCl 4 group; received PO and 2 mL/kg CCl 4 orally. The relative liver weight was recorded. Serum liver enzymes, hepatic malondialdehyde (MDA), hepatic reduced glutathione (GSH) and the expression of hepatic tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) were assessed. The binding affinities of γ-linolenic acid and D/L-alpha tocopherol constituents with IL-1β, IL-6 and TNF-α were investigated using molecular docking simulations. Histopathological and electron microscopic examinations of the liver were performed. The results indicated that CCl 4 elevated serum liver enzyme and hepatic MDA levels, whereas GSH levels were diminished. The upregulation of IL-1β, IL-6, and TNF-α gene expressions were induced by CCl 4 treatment. The PO/CCl4-treated group showed amelioration of hepatic injury biomarkers and oxidative stress. Restoration of histopathological and ultrastructural alterations while downregulations the gene expressions of TNF-α, IL1-β and IL-6 were observed. In conclusion, evening primrose oil enriched with γ-linolenic acid and D/L-alpha tocopherol acetate elicited a potential amelioration of CCl 4 -induced hepatic toxicity.
فهرسة مساهمة: Keywords: CCl4; D/L-alpha tocopherol; Primrose oil; anti-inflammatory; histopathology; liver; γ-linolenic acid
تواريخ الأحداث: Date Created: 20240103 Date Completed: 20240515 Latest Revision: 20240613
رمز التحديث: 20240613
DOI: 10.1080/15376516.2023.2301357
PMID: 38166523
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6524
DOI:10.1080/15376516.2023.2301357