دورية أكاديمية
PDE5 inhibitors: breaking new grounds in the treatment of COVID-19.
العنوان: | PDE5 inhibitors: breaking new grounds in the treatment of COVID-19. |
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المؤلفون: | Varghese R; Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India.; Department of Clinical Pharmacology, Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.; Homi Bhabha National Institute, Mumbai, Maharashtra, India., Digholkar G; Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India., Karsiya J; River Route Creative Group LLP, Mumbai, Maharashtra, India., Salvi S; Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India., Shah J; Department of Pulmonology, Saifee Hospital, Girgaon, Mumbai, Maharashtra, India., Kumar D; Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India.; Department of Entomology, University of California, Davis, CA, USA.; UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA., Sharma R; Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. |
المصدر: | Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2023 Aug 24; Vol. 38 (4), pp. 295-307. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: De Gruyter Country of Publication: Germany NLM ID: 101653409 Publication Model: eCollection Cited Medium: Internet ISSN: 2363-8915 (Electronic) Linking ISSN: 23638915 NLM ISO Abbreviation: Drug Metab Pers Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : De Gruyter, [2015]- |
مواضيع طبية MeSH: | Phosphodiesterase 5 Inhibitors*/therapeutic use , COVID-19*, Humans ; Sildenafil Citrate ; Tadalafil ; Vardenafil Dihydrochloride ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Piperazines/pharmacology ; Imidazoles/adverse effects ; Carbolines/adverse effects ; Purines/adverse effects ; SARS-CoV-2 |
مستخلص: | Introduction: Despite the ever-increasing occurrences of the coronavirus disease (COVID-19) cases around the world, very few medications have been validated in the clinical trials to combat COVID-19. Although several vaccines have been developed in the past quarter, the time elapsed between deployment and administration remains a major impediment. Content: Repurposing of pre-approved drugs, such as phosphodiesterase 5 (PDE5) inhibitors, could be a game-changer while lessening the burden on the current healthcare system. Repurposing and developing phosphodiesterase 5 (PDE5) inhibitors could extrapolate their utility to combat the SARS-CoV-2 infection, and potentially aid in the management of the symptoms associated with its newer variants such as BF.7, BQ.1, BQ.1.1, XBB.1.5, and XBB.1.16. Summary: Administration of PDE5 inhibitors via the oral and intravenous route demonstrates other potential off-label benefits, including anti-apoptotic, anti-inflammatory, antioxidant, and immunomodulatory effects, by intercepting several pathways. These effects can not only be of clinical importance in mild-to-moderate, but also moderate-to-severe SARS-CoV-2 infections. This article explores the various mechanisms by which PDE5 inhibitors alleviates the symptoms associated with COVID-19 as well as well as highlights recent studies and findings. Outlook: These benefits of PDE5 inhibitors make it a potential drug in the physicians' armamentarium in alleviating symptoms associated with SARS-CoV-2 infection. However, adequate clinical studies must be instituted to eliminate any untoward adverse events. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.) |
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فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; delta; omicron; phosphodiesterase 5 inhibitors; sildenafil; tadalafil |
المشرفين على المادة: | 0 (Phosphodiesterase 5 Inhibitors) BW9B0ZE037 (Sildenafil Citrate) 742SXX0ICT (Tadalafil) 5O8R96XMH7 (Vardenafil Dihydrochloride) EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5) 0 (Piperazines) 0 (Imidazoles) 0 (Carbolines) 0 (Purines) |
تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240105 Latest Revision: 20240105 |
رمز التحديث: | 20240105 |
DOI: | 10.1515/dmpt-2023-0011 |
PMID: | 38167268 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2363-8915 |
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DOI: | 10.1515/dmpt-2023-0011 |