دورية أكاديمية
Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task.
| العنوان: | Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task. |
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| المؤلفون: | Li S; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. shutingli36@gmail.com.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia. shutingli36@gmail.com., May C; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia., Pang TY; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia., Churilov L; Melbourne Medical School, The University of Melbourne, Parkville, VIC, 3010, Australia., Hannan AJ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia., Johnson KA; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia., Burrows EL; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia. emma.burrows@florey.edu.au. |
| المصدر: | Psychopharmacology [Psychopharmacology (Berl)] 2024 Mar; Vol. 241 (3), pp. 555-567. Date of Electronic Publication: 2024 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Autistic Disorder*, Mice ; Humans ; Animals ; Atomoxetine Hydrochloride/pharmacology ; Neuroligins ; Mutation/genetics ; Attention |
| مستخلص: | Rationale: Atypical attention orienting has been associated with some autistic symptoms, but the neural mechanisms remain unclear. The human Posner task, a classic attention orienting paradigm, was recently adapted for use with mice, supporting the investigation of the neurobiological underpinnings of atypical attention orienting in preclinical mouse models. Objective: The current study tested mice expressing the autism-associated R451C gene mutation in neuroligin-3 (NL3) on the mouse-Posner (mPosner) task. Methods: NL3 R451C and wild-type (WT) mice were trained to respond to a validly or invalidly cued target on a touchscreen. The cue was a peripheral non-predictive flash in the exogenous task and a central spatially predictive image in the endogenous task. The effects of dopaminergic- and noradrenergic-modulating drugs, methylphenidate and atomoxetine, on task performance were assessed. Results: In both tasks, mice were quicker and more accurate in the validly versus invalidly cued trials, consistent with results in the human Posner task. NL3 R451C and WT mice showed similar response times and accuracy but responded differently when treated with methylphenidate and atomoxetine. Methylphenidate impaired exogenous attention disengagement in NL3 R451C mice but did not significantly affect WT mice. Atomoxetine impaired endogenous orienting in WT mice but did not significantly affect NL3 R451C mice. Conclusions: NL3 R451C mice demonstrated intact attention orienting but altered responses to the pharmacological manipulation of the dopaminergic and noradrenergic networks. These findings expand our understanding of the NL3 R451C mutation by suggesting that this mutation may lead to selective alterations in attentional processes. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | 1111552 National Health and Medical Research Council-Australian Research Council; FT100100835 Australian Research Council |
| فهرسة مساهمة: | Keywords: Attention orienting; Autism spectrum disorder; Mouse model; Mouse-Posner task; Neuroligin-3 R451C mutation; Touchscreen test |
| المشرفين على المادة: | 57WVB6I2W0 (Atomoxetine Hydrochloride) 0 (Neuroligins) |
| تواريخ الأحداث: | Date Created: 20240103 Date Completed: 20240226 Latest Revision: 20240226 |
| رمز التحديث: | 20240226 |
| DOI: | 10.1007/s00213-023-06520-6 |
| PMID: | 38170320 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00213-023-06520-6 |