دورية أكاديمية
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TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons.

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العنوان: TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons.
المؤلفون: Yang G; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China.; Department of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China.; Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, China., Jia M; Department of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Li G; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China., Zang YY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China.; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China., Chen YY; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China., Wang YY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China.; Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, China., Zhan SY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China.; Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, China., Peng SX; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China., Wan G; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China., Li W; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China. wei.li@nju.edu.cn., Yang JJ; Department of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. yjyangjj@126.com., Shi YS; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurosurgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China. shiyun@gdiist.cn.; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu, China. shiyun@gdiist.cn.; Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, China. shiyun@gdiist.cn.
المصدر: Cell discovery [Cell Discov] 2024 Jan 03; Vol. 10 (1), pp. 1. Date of Electronic Publication: 2024 Jan 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101661034 Publication Model: Electronic Cited Medium: Print ISSN: 2056-5968 (Print) Linking ISSN: 20565968 NLM ISO Abbreviation: Cell Discov Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Publishing Group, [2015]-
مستخلص: Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the subfornical organ (SFO) are intrinsically osmosensitive and their activation by hyperosmolarity is necessary and sufficient for generating thirst. However, the primary molecules sensing systemic osmolarity in these neurons remain elusive. Here we show that the mechanosensitive TMEM63B cation channel is the osmosensor required for the interoceptive neurons to drive thirst. TMEM63B channel is highly expressed in the excitatory SFO thirst neurons. TMEM63B deletion in these neurons impaired hyperosmolarity-induced drinking behavior, while re-expressing TMEM63B in SFO restored water appetite in TMEM63B-deficient mice. Remarkably, hyperosmolarity activates TMEM63B channels, leading to depolarization and increased firing rate of the interoceptive neurons, which drives drinking behavior. Furthermore, TMEM63B deletion did not affect sensitivities of the SFO neurons to angiotensin II or hypoosmolarity, suggesting that TMEM63B plays a specialized role in detecting hyperosmolarity in SFO neurons. Thus, our results reveal a critical osmosensor molecule for the generation of thirst perception.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 82171189 National Natural Science Foundation of China (National Science Foundation of China); 32330044 National Natural Science Foundation of China (National Science Foundation of China); BE2019707 Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation); BK20201113 Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation)
تواريخ الأحداث: Date Created: 20240103 Latest Revision: 20240106
رمز التحديث: 20240106
مُعرف محوري في PubMed: PMC10764952
DOI: 10.1038/s41421-023-00628-x
PMID: 38172113
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-5968
DOI:10.1038/s41421-023-00628-x