دورية أكاديمية
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Patterning of the cell cortex by Rho GTPases.

التفاصيل البيبلوغرافية
العنوان: Patterning of the cell cortex by Rho GTPases.
المؤلفون: Bement WM; Center for Quantitative Cell Imaging, Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI, USA. wmbement@wisc.edu., Goryachev AB; Center for Engineering Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. andrew.goryachev@ed.ac.uk., Miller AL; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. annlm@mich.edu., von Dassow G; Oregon Institute of Marine Biology, Charleston, OR, USA. dassow@uoregon.edu.
المصدر: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2024 Apr; Vol. 25 (4), pp. 290-308. Date of Electronic Publication: 2024 Jan 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Nature Pub. Group, [2000-
مواضيع طبية MeSH: rho GTP-Binding Proteins*/metabolism , Cytoskeleton*/metabolism, Actins/metabolism ; Signal Transduction ; Cell Movement ; rac1 GTP-Binding Protein/metabolism
مستخلص: The Rho GTPases - RHOA, RAC1 and CDC42 - are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and morphogenesis by promoting cytoskeleton-based changes in the cell cortex. This regulation results from active (GTP-bound) Rho GTPases stimulating target proteins that, in turn, promote actin assembly and myosin 2-based contraction to organize the cortex. This basic regulatory scheme, well supported by in vitro studies, led to the natural assumption that Rho GTPases function in vivo in an essentially linear matter, with a given process being initiated by GTPase activation and terminated by GTPase inactivation. However, a growing body of evidence based on live cell imaging, modelling and experimental manipulation indicates that Rho GTPase activation and inactivation are often tightly coupled in space and time via signalling circuits and networks based on positive and negative feedback. In this Review, we present and discuss this evidence, and we address one of the fundamental consequences of coupled activation and inactivation: the ability of the Rho GTPases to self-organize, that is, direct their own transition from states of low order to states of high order. We discuss how Rho GTPase self-organization results in the formation of diverse spatiotemporal cortical patterns such as static clusters, oscillatory pulses, travelling wave trains and ring-like waves. Finally, we discuss the advantages of Rho GTPase self-organization and pattern formation for cell function.
(© 2024. Springer Nature Limited.)
التعليقات: Erratum in: Nat Rev Mol Cell Biol. 2024 Jan 15;:. (PMID: 38225281)
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المشرفين على المادة: EC 3.6.5.2 (rho GTP-Binding Proteins)
0 (Actins)
EC 3.6.5.2 (rac1 GTP-Binding Protein)
تواريخ الأحداث: Date Created: 20240103 Date Completed: 20240328 Latest Revision: 20240328
رمز التحديث: 20240329
DOI: 10.1038/s41580-023-00682-z
PMID: 38172611
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-0080
DOI:10.1038/s41580-023-00682-z