دورية أكاديمية
Integrated Bioinformatics Analysis and Target Drug Prediction of Inflammatory Bowel Disease Co-existent Diabetes Mellitus.
| العنوان: | Integrated Bioinformatics Analysis and Target Drug Prediction of Inflammatory Bowel Disease Co-existent Diabetes Mellitus. |
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| المؤلفون: | Yang L; Jingwen Library, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Jiangsu Provincial Engineering Center of TCM External Medication Researching and Industrializing, Nanjing University of Chinese Medicine, Nanjing 210023, China., Wang N; School of Acupuncture-Moxibustion and Tuina College, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, China., Wang Y; School of Acupuncture-Moxibustion and Tuina College, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, China., Li W; School of Acupuncture-Moxibustion and Tuina College, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, China., Kong Z; School of Acupuncture-Moxibustion and Tuina College, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, China., Zhang B; Department of Internal Medicine, Ningbo Municipal Hospital of TCM, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315012, China., Bian Y; Jiangsu Provincial Engineering Center of TCM External Medication Researching and Industrializing, Nanjing University of Chinese Medicine, Nanjing 210023, China.; School of Acupuncture-Moxibustion and Tuina College, School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing 210023, China. |
| المصدر: | Current computer-aided drug design [Curr Comput Aided Drug Des] 2024 Jan 03. Date of Electronic Publication: 2024 Jan 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101265750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-6697 (Electronic) Linking ISSN: 15734099 NLM ISO Abbreviation: Curr Comput Aided Drug Des Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2005- |
| مستخلص: | Introduction: Inflammatory bowel disease (IBD) has become one of the public problems worldwide and its incidence rate is increasing year by year. Its concomitant disease i.e. diabetes mellitus (DM) has attracted more and more attention due to DM altering the progression of IBD and leading to long periods of intermittent recurrence and deterioration. The common mechanism and potential target drug of IBD with comorbid chronic conditions of DM were explored. Methods: Gene expression profile data were downloaded from the Gene Expression Omnibus (GEO) public database. The differentially expressed genes (DEGs) were identified by R software. GO annotation and pathway enrichment were performed, a protein-protein interaction (PPI) network was constructed, associated lncRNAs were predicted and drug prediction targeting key genes was made. Additionally, the regulatory network among core genes, associated pathways, and predicted lncRNA in IBD with coexistent DM were visualized. Results: We identified the critical gene MMP3 with lncRNA CDKN2BAS involved in the PPAR pathway, which uncovered the underlying regulatory mechanism of IBD with coexistent DM. We also predicted the potential therapeutic compound ZINC05905909 acting on MMP3. Conclusion: Our findings revealed the regulatory mechanism chain of critical gene MMP3, lncRNA CDKN2BAS, and PPAR pathway and provided potential therapeutic compound ZINC05905909 for drug therapy to treat comorbid IBD DM. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; Inflammatory bowel disease; Integrated bioinformatics analysis; Targeted drug prediction |
| تواريخ الأحداث: | Date Created: 20240104 Latest Revision: 20240104 |
| رمز التحديث: | 20240104 |
| DOI: | 10.2174/0115734099282247231211111219 |
| PMID: | 38173213 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-6697 |
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| DOI: | 10.2174/0115734099282247231211111219 |