دورية أكاديمية
Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil.
| العنوان: | Analysis of associations between the TLR3 SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil. |
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| المؤلفون: | Silva MJA; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Vieira MCDS; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Souza AB; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Dos Santos EC; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Marcelino BDR; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Casseb SMM; Molecular Biology Laboratory, Pathology Section (SEPAT), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Lima KVB; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil., Lima LNGC; Molecular Biology Laboratory, Bacteriology and Mycology Section (SABMI), Evandro Chagas Institute (IEC), Ananindeua, Brazil. |
| المصدر: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Dec 19; Vol. 13, pp. 1320701. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide* , COVID-19*/genetics, Humans ; Toll-Like Receptor 3/genetics ; Genetic Predisposition to Disease ; Case-Control Studies ; Brazil/epidemiology ; Genotype |
| مستخلص: | The objective of this article was to verify associations between the SNPs rs3775291 (Cytosine [C]>Thymine [T]) and rs3775290 (C>T) of TLR3 in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was carried out with workers from HI in Belém-PA, Brazil, divided into symptomatology groups (Asymptomatic-AS, n =91; and Symptomatic-SI, n =121), and severity groups, classified by Chest CT scan (symptomatic with lung involvement - SCP, n =34; symptomatic without lung involvement - SSP, n =8). Genotyping was performed by Sanger sequencing and statistical analysis was performed using the SPSS program. In the analysis of SNP rs3775291, the homozygous recessive genotype (T/T) was not found and the frequency of the mutant allele (T) was less than 2% in the cohort. For the rs3775290 SNP, the frequency of the mutant allele (T) was greater than 42% in the cohort. No significant associations were found for these SNPs in this cohort (N= 212 individuals). The scientific community and physicians can use these facts to find new methods of managing COVID-19. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Silva, Vieira, Souza, Santos, Marcelino, Casseb, Lima and Lima.) |
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| فهرسة مساهمة: | Keywords: COVID-19; TLR3; epidemiology; genetics; single nucleotide polymorphism |
| المشرفين على المادة: | 0 (Toll-Like Receptor 3) 0 (TLR3 protein, human) |
| تواريخ الأحداث: | Date Created: 20240104 Date Completed: 20240105 Latest Revision: 20240223 |
| رمز التحديث: | 20240223 |
| مُعرف محوري في PubMed: | PMC10763251 |
| DOI: | 10.3389/fcimb.2023.1320701 |
| PMID: | 38173795 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2023.1320701 |