دورية أكاديمية
IGF-PLGA microspheres promote angiogenesis and accelerate skin flap repair and healing by inhibiting oxidative stress and regulating the Ang 1/Tie 2 signaling pathway.
| العنوان: | IGF-PLGA microspheres promote angiogenesis and accelerate skin flap repair and healing by inhibiting oxidative stress and regulating the Ang 1/Tie 2 signaling pathway. |
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| المؤلفون: | Hu F; Cixi Biomedical Research Institute, Wenzhou Medical University, Cixi, Ningbo, China., Huang K; Department of Orthopaedic Surgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999, South Second Ring Road, Hushan Street, Cixi, Ningbo 315300, China., Zhang H; Cixi Biomedical Research Institute, Wenzhou Medical University, Cixi, Ningbo, China., Hu W; Department of Orthopaedic Surgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999, South Second Ring Road, Hushan Street, Cixi, Ningbo 315300, China., Tong S; Department of Orthopaedic Surgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999, South Second Ring Road, Hushan Street, Cixi, Ningbo 315300, China., Xu H; Department of Orthopaedic Surgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999, South Second Ring Road, Hushan Street, Cixi, Ningbo 315300, China. Electronic address: 104497554@qq.com. |
| المصدر: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Feb 01; Vol. 193, pp. 106687. Date of Electronic Publication: 2024 Jan 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science B.V Original Publication: Amsterdam ; New York : Elsevier, c1993- |
| مواضيع طبية MeSH: | Angiopoietin-1*/metabolism , Insulin-Like Growth Factor I*/pharmacology, Animals ; Humans ; Angiogenesis ; Delayed-Action Preparations ; Endothelial Cells ; Microspheres ; Oxidative Stress ; Polylactic Acid-Polyglycolic Acid Copolymer ; Signal Transduction ; Receptor, TIE-2/drug effects ; Receptor, TIE-2/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism |
| مستخلص: | Random flaps are widely used in the treatment of injuries, tumors, congenital malformations, and other diseases. However, postoperative skin flaps are prone to ischemic necrosis, leading to surgical failure. Insulin-like growth factor- 1(IGF-1) belongs to the IGF family and exerts its growth-promoting effects in various tissues through autocrine or paracrine mechanisms. Its application in skin flaps and other traumatic diseases is relatively limited. Poly (lactic-co-glycolic acid) (PLGA) is a degradable high-molecular-weight organic compound commonly used in biomaterials. This study prepared IGF-PLGA sustained-release microspheres to explore their impact on the survival rate of flaps both in vitro and in vivo, as well as the mechanisms involved. The research results demonstrate that IGF-PLGA has a good sustained-release effect. At the cellular level, it can promote 3T3 cell proliferation by inhibiting oxidative stress, inhibit apoptosis, and enhance the tube formation ability of human umbilical vein endothelial cells (HUVEC) . At the animal level, it accelerates flap healing by promoting vascularization through the inhibition of oxidative stress. Furthermore, this study reveals the role of IGF-PLGA in activating the Angiopoietin-1(Ang1)/Tie2 signaling pathway in promoting flap vascularization, providing a strong theoretical basis and therapeutic target for the application of IGF-1 in flaps and other traumatic diseases. Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Angiogenesis; Flap; IGF-PLGA; Microspheres; Oxidative stress |
| المشرفين على المادة: | 0 (Angiopoietin-1) 0 (Delayed-Action Preparations) 67763-96-6 (Insulin-Like Growth Factor I) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) EC 2.7.10.1 (TEK protein, human) EC 2.7.10.1 (Receptor, TIE-2) |
| تواريخ الأحداث: | Date Created: 20240104 Date Completed: 20240208 Latest Revision: 20240208 |
| رمز التحديث: | 20240208 |
| DOI: | 10.1016/j.ejps.2023.106687 |
| PMID: | 38176662 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0720 |
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| DOI: | 10.1016/j.ejps.2023.106687 |