Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.

التفاصيل البيبلوغرافية
العنوان:	Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
المؤلفون:	Little AS; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Younker IT; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Schechter MS; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Bernardino PN; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Méheust R; Génomique Métabolique, CEA, Genoscope, Institut François Jacob, Université d'Évry, Université Paris-Saclay, CNRS, Evry, France., Stemczynski J; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Scorza K; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Mullowney MW; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Sharan D; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA., Waligurski E; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Smith R; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Ramanswamy R; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Leiter W; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Moran D; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., McMillin M; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Odenwald MA; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA., Iavarone AT; QB3/Chemistry Mass Spectrometry Facility, University of California, Berkeley, Berkeley, CA, USA., Sidebottom AM; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Sundararajan A; Duchossois Family Institute, University of Chicago, Chicago, IL, USA., Pamer EG; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.; Department of Microbiology, University of Chicago, Chicago, IL, USA.; Section of Infectious Diseases & Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA., Eren AM; Helmholtz Institute for Functional Marine Biodiversity, Oldenburg, Germany.; Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Oldenbug, Germany., Light SH; Duchossois Family Institute, University of Chicago, Chicago, IL, USA. samlight@uchicago.edu.; Department of Microbiology, University of Chicago, Chicago, IL, USA. samlight@uchicago.edu.
المصدر:	Nature microbiology [Nat Microbiol] 2024 Jan; Vol. 9 (1), pp. 55-69. Date of Electronic Publication: 2024 Jan 04.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [London] : Nature Publishing Group, [2016]-
مواضيع طبية MeSH:	Ecosystem* , Bacteria/genetics , Bacteria/metabolism, Humans ; Anaerobiosis ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Respiration
مستخلص:	Respiratory reductases enable microorganisms to use molecules present in anaerobic ecosystems as energy-generating respiratory electron acceptors. Here we identify three taxonomically distinct families of human gut bacteria (Burkholderiaceae, Eggerthellaceae and Erysipelotrichaceae) that encode large arsenals of tens to hundreds of respiratory-like reductases per genome. Screening species from each family (Sutterella wadsworthensis, Eggerthella lenta and Holdemania filiformis), we discover 22 metabolites used as respiratory electron acceptors in a species-specific manner. Identified reactions transform multiple classes of dietary- and host-derived metabolites, including bioactive molecules resveratrol and itaconate. Products of identified respiratory metabolisms highlight poorly characterized compounds, such as the itaconate-derived 2-methylsuccinate. Reductase substrate profiling defines enzyme-substrate pairs and reveals a complex picture of reductase evolution, providing evidence that reductases with specificities for related cinnamate substrates independently emerged at least four times. These studies thus establish an exceptionally versatile form of anaerobic respiration that directly links microbial energy metabolism to the gut metabolome. (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة:	K22 AI144031 United States AI NIAID NIH HHS; R35 GM146969 United States GM NIGMS NIH HHS; S10 OD020062 United States OD NIH HHS; T32 DK007074 United States DK NIDDK NIH HHS
المشرفين على المادة:	Q4516562YH (itaconic acid) EC 1.- (Oxidoreductases)
تواريخ الأحداث:	Date Created: 20240104 Date Completed: 20240108 Latest Revision: 20240808
رمز التحديث:	20240809
مُعرف محوري في PubMed:	PMC11055453
DOI:	10.1038/s41564-023-01560-2
PMID:	38177297
قاعدة البيانات:	MEDLINE

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DOI:	10.1038/s41564-023-01560-2