دورية أكاديمية
Enhancing clinical awareness: retrospective analysis of neurosyphilis cases and diagnostic predictors for early recognition and treatment.
| العنوان: | Enhancing clinical awareness: retrospective analysis of neurosyphilis cases and diagnostic predictors for early recognition and treatment. |
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| المؤلفون: | Gao YS; Department of Dermatology, Beijing Tiantan Hospital, Capital Medical University, No. 119 of Nansihuanxilu Street, Fengtai District, Beijing, 100070, China., Li Q; Department of Dermatology, Beijing Tiantan Hospital, Capital Medical University, No. 119 of Nansihuanxilu Street, Fengtai District, Beijing, 100070, China. liqingllm@21cn.com., Zhou H; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, 100070, China., Zhang ZQ; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, 100070, China., Feng H; Department of Dermatology, Beijing Tiantan Hospital, Capital Medical University, No. 119 of Nansihuanxilu Street, Fengtai District, Beijing, 100070, China., Liu GF; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, 100070, China., Shen Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, 100070, China. |
| المصدر: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Jun; Vol. 45 (6), pp. 2825-2833. Date of Electronic Publication: 2024 Jan 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| مواضيع طبية MeSH: | Neurosyphilis*/diagnosis , Neurosyphilis*/complications , Early Diagnosis*, Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Adult ; Aged ; Tabes Dorsalis/diagnosis ; Tabes Dorsalis/complications |
| مستخلص: | Objective: This is a retrospective analysis of clinical data from individuals diagnosed with neurosyphilis, aiming to enhance healthcare professionals' understanding of the disease and expedite early diagnosis and intervention. Methods: A retrospective analysis was conducted on the clinical records of 50 patients who received a diagnosis of symptomatic neurosyphilis and were admitted to the Neurology Department during the period spanning January 2012 to December 2022. Results: Clinical manifestations encompassed diverse phenotypes, with syphilitic meningitis accounting for 16% of cases, characterized by symptoms such as headache, blepharoptosis, paralysis, blurred vision, and tinnitus. Meningovascular syphilis presented in 36% of cases, exhibiting episodic loss of consciousness, limb numbness, and limb convulsion. Paralytic dementia manifested in 36% of cases, featuring symptoms such as memory loss, sluggish response, and slow movement. Tabes dorsalis was observed in 12% of cases, presenting with weakness, numbness, and staggering. Routine cerebrospinal fluid (CSF) analysis indicated abnormal white blood cell counts in 60% of patients, while biochemical testing revealed abnormal protein content in 52% of patients. Notably, statistically significant differences were observed between patients with interstitial and parenchymatous neurosyphilis (Z = 2.023, P = 0.044) in terms of CSF protein content. Electroencephalogram (EEG) results were abnormal in six patients, and imaging studies unveiled diverse findings in 46 patients. Conclusion: The study highlights the importance of neurological and/or ocular symptoms in diagnosing symptomatic neurosyphilis. Individuals with hypomnesia should be closely monitored for potential neurosyphilis. Integrating clinical manifestations, laboratory tests, EEG, and imaging can reduce misdiagnosis. This comprehensive approach shows promise in improving early identification and management of neurosyphilis. (© 2024. Fondazione Società Italiana di Neurologia.) |
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| فهرسة مساهمة: | Keywords: Cerebrospinal fluid; Clinical manifestations; EEG; Imaging; Neurosyphilis |
| تواريخ الأحداث: | Date Created: 20240104 Date Completed: 20240509 Latest Revision: 20240509 |
| رمز التحديث: | 20240510 |
| DOI: | 10.1007/s10072-023-07285-8 |
| PMID: | 38177969 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1590-3478 |
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| DOI: | 10.1007/s10072-023-07285-8 |