دورية أكاديمية
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages.
| العنوان: | Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages. |
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| المؤلفون: | Saldivia N; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Center for Advanced Microscopy, CMA BIO BIO, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile., Salazar K; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Center for Advanced Microscopy, CMA BIO BIO, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile., Cifuentes M; Department of Cell Biology, Genetics and Physiology, Universidad de Málaga, IBIMA, Málaga, Spain., Espinoza F; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Center for Advanced Microscopy, CMA BIO BIO, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile., Harrison FE; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA., Nualart F; Laboratory of Neurobiology and Stem Cells, NeuroCellT, Department of Cellular Biology, Center for Advanced Microscopy, CMA BIO BIO, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. |
| المصدر: | Glia [Glia] 2024 Apr; Vol. 72 (4), pp. 708-727. Date of Electronic Publication: 2024 Jan 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: New York : Alan R. Liss, Inc., c1988- |
| مواضيع طبية MeSH: | Ascorbic Acid*/pharmacology , Sodium-Coupled Vitamin C Transporters*/genetics, Animals ; Humans ; Mice ; Ependymoglial Cells/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Membrane Transport Proteins/metabolism ; Mice, Transgenic ; Neurons/metabolism |
| مستخلص: | Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of lRG and molecules that may be involved in their differentiation is based on very limited data. We analyzed whether ascorbic acid (AA) and its transporter SVCT2, are involved in lRG cells differentiation. We demonstrated that lRG cells are highly present between the first and fourth postnatal days. Anatomical characterization of lRG cells, revealed that lRG cells maintained their bipolar morphology and stem-like character. When lRG cells were labeled with adenovirus-eGFP at 1 postnatal day, we detected that some cells display an obvious migratory neuronal phenotype, suggesting that lRG cells continue generating neurons postnatally. Moreover, we demonstrated that SVCT2 was apically polarized in lRG cells. In vitro studies using the transgenic mice SVCT2 +/- and SVCT2 tg (SVCT2-overexpressing mouse), showed that decreased SVCT2 levels led to accelerated differentiation into astrocytes, whereas both AA treatment and elevated SVCT2 expression maintain the lRG cells in an undifferentiated state. In vivo overexpression of SVCT2 in lRG cells generated cells with a rounded morphology that were migratory and positive for proliferation and neuronal markers. We also examined mediators that can be involved in AA/SVCT2-modulated signaling pathways, determining that GSK3-β through AKT, mTORC2, and PDK1 is active in brains with high levels of SVCT2/AA. Our data provide new insights into the role of AA and SVCT2 in late RG cells. (© 2024 The Authors. GLIA published by Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | ECM12 Agencia Nacional de Investigación y Desarrollo (ANID) - Programa de Investigación Asociativa (PIA) Chile; 1190848 Fondo Nacional de Desarrollo Científico y Tecnológico; 1221147 Fondo Nacional de Desarrollo Científico y Tecnológico |
| فهرسة مساهمة: | Keywords: SVCT2; ascorbic acid; cerebral cortex; late radial glia; neuronal differentiation; vitamin C |
| المشرفين على المادة: | PQ6CK8PD0R (Ascorbic Acid) EC 2.7.11.26 (Glycogen Synthase Kinase 3) 0 (Membrane Transport Proteins) 0 (Sodium-Coupled Vitamin C Transporters) 0 (Slc23a1 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240105 Date Completed: 20240222 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1002/glia.24498 |
| PMID: | 38180226 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-1136 |
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| DOI: | 10.1002/glia.24498 |