Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study.

التفاصيل البيبلوغرافية
العنوان:	Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study.
المؤلفون:	Kunutsor SK; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4WP, UK. skk31@cantab.net., Seidu S; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4WP, UK., Kurl S; Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Laukkanen JA; Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Wellbeing Services County of Central Finland, Department of Medicine, Jyväskylä, Finland.
المصدر:	GeroScience [Geroscience] 2024 Jun; Vol. 46 (3), pp. 3035-3046. Date of Electronic Publication: 2024 Jan 05.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH:	Diabetes Mellitus, Type 2* , Renal Insufficiency, Chronic*/epidemiology, Male ; Humans ; Prospective Studies ; Glucose ; Triglycerides ; Blood Glucose/analysis
مستخلص:	Triglyceride-glucose (TyG) index is an emerging marker of adverse cardiometabolic conditions such as cardiovascular disease and type 2 diabetes. The long-term relevance of TyG index to chronic kidney disease (CKD) is uncertain. We aimed to assess the association of TyG index with CKD risk and its utility in risk prediction in a prospective study. The TyG index was calculated using fasting triglycerides and fasting plasma glucose (FPG) levels measured in 2362 men aged 42-61 years with normal kidney function using the formula: Ln (fasting triglycerides [mg/dL] × FPG [mg/dL]/2). Multivariable adjusted hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for CKD. Correction for within-person variability was made using data from repeat measurements of triglycerides and FPG taken 11 years after baseline. Over a median follow-up duration of 17.5 years, 223 CKD cases were recorded. The age-adjusted regression dilution ratio for the TyG index was 0.54 (95% CI, 0.48-0.60). The risk of CKD increased continuously with increasing TyG index across the range 9.3 to 11.6 (p value for nonlinearity<.001). In analysis adjusted for established risk factors, a unit higher TyG index was associated with an increased risk of CKD (HR 1.59, 95% CI 1.24-2.05). Comparing extreme tertiles of the TyG index, the corresponding adjusted HR (95% CI) for CKD was 1.61 (1.15-2.27). Addition of the TyG index to a CKD risk prediction model containing established risk factors improved risk discrimination and reclassification (p value for difference in -2 log likelihood<.001; NRI=47.66%, p=.014; IDI=0.0164, p<.001). Higher TyG index is associated with an increased risk of CKD and improves the prediction and classification of CKD beyond established risk factors. Using single baseline estimations of the TyG index to investigate its association with CKD risk could considerably under-estimate the true association. (© 2024. The Author(s).)
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فهرسة مساهمة:	Keywords: Chronic kidney disease; Cohort study; Triglyceride-glucose index
المشرفين على المادة:	IY9XDZ35W2 (Glucose) 0 (Triglycerides) 0 (Blood Glucose)
تواريخ الأحداث:	Date Created: 20240105 Date Completed: 20240415 Latest Revision: 20240722
رمز التحديث:	20240722
مُعرف محوري في PubMed:	PMC11009217
DOI:	10.1007/s11357-023-01044-5
PMID:	38180700
قاعدة البيانات:	MEDLINE

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تدمد:	2509-2723
DOI:	10.1007/s11357-023-01044-5