دورية أكاديمية
Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients.
| العنوان: | Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients. |
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| المؤلفون: | Howard LM; Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA., Jensen TL; The Emmes Company, LLC, Biomedical Data Science and Bioinformatics Department, Rockville, MD, USA., Goll JB; The Emmes Company, LLC, Biomedical Data Science and Bioinformatics Department, Rockville, MD, USA., Gelber CE; The Emmes Company, LLC, Biomedical Data Science and Bioinformatics Department, Rockville, MD, USA., Bradley MD; The Emmes Company, LLC, Biomedical Data Science and Bioinformatics Department, Rockville, MD, USA., Sherrod SD; Department of Chemistry and Center for Innovative Technology, Vanderbilt University, Nashville, TN, USA., Hoek KL; Vanderbilt Institute for Infection, Inflammation and Immunity (VI4), Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA., Yoder S; Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA., Jimenez-Truque N; Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA., Edwards K; Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA., Creech CB; Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine and Medical Center, Nashville, TN, USA. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 Jan 05. Date of Electronic Publication: 2024 Jan 05. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مستخلص: | Background: Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants. Methods: Twenty healthy men and women (18-49 years of age) were randomized to receive two doses of inactivated influenza A/H5N1 vaccine alone (IIV) or with AS03 adjuvant (IIV-AS03) one month apart. Urine and serum samples were collected on day 0 and on days 1, 3, and 7 following first vaccination and subjected to metabolomics analyses to identify metabolites, metabolic pathways, and metabolite clusters associated with immunization. Results: Seventy-three differentially abundant (DA) serum and 88 urine metabolites were identified for any post-vaccination day comparison. Pathway analysis revealed enrichment of tryptophan, tyrosine and nicotinate metabolism in urine and serum among IIV-AS03 recipients. Increased urine abundance of 4-vinylphenol sulfate on Day 1 was associated with serologic response based on hemagglutination inhibition responses. In addition, 9 DA urine metabolites were identified in participants with malaise compared to those without. Conclusions: Our findings suggest that tryptophan, tyrosine, and nicotinate metabolism are upregulated among IIV-AS03 recipients compared with IIV alone. Metabolites within these pathways may serve as measures of immunogenicity and may provide mechanistic insights for adjuvanted vaccines. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: AS03; Adjuvant; Adversomics; Influenza; Metabolomics; Vaccination |
| تواريخ الأحداث: | Date Created: 20240105 Latest Revision: 20240105 |
| رمز التحديث: | 20240106 |
| DOI: | 10.1093/infdis/jiad611 |
| PMID: | 38181048 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiad611 |