دورية أكاديمية
Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium.
| العنوان: | Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium. |
|---|---|
| المؤلفون: | Elliott JE; VA Portland Health Care System, Research Service, Portland, OR, USA.; Oregon Health and Science University, Department of Neurology, Portland, OR, USA., Ligman BR; VA Portland Health Care System, Research Service, Portland, OR, USA., Bryant-Ekstrand MD; VA Portland Health Care System, Research Service, Portland, OR, USA., Keil AT; VA Portland Health Care System, Research Service, Portland, OR, USA.; McGill University, Montreal Neurological Institute and Department of Neurology and Neurosurgery, Montréal, QC, Canada., Powers K; VA Portland Health Care System, Research Service, Portland, OR, USA., Olivo C; VA Portland Health Care System, Research Service, Portland, OR, USA., Neilson LE; VA Portland Health Care System, Research Service, Portland, OR, USA.; Oregon Health and Science University, Department of Neurology, Portland, OR, USA., Postuma RB; McGill University, Montreal Neurological Institute and Department of Neurology and Neurosurgery, Montréal, QC, Canada.; Université du Québec à Montréal, Département of Psychology, Montréal, QC, Canada.; Hôpital du Sacré-Coeur de Montréal, Center for Advanced Research in Sleep Medicine, Montréal, QC, Canada.; Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Pelletier A; Hôpital du Sacré-Coeur de Montréal, Center for Advanced Research in Sleep Medicine, Montréal, QC, Canada.; Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Gagnon JF; Université du Québec à Montréal, Département of Psychology, Montréal, QC, Canada.; Hôpital du Sacré-Coeur de Montréal, Center for Advanced Research in Sleep Medicine, Montréal, QC, Canada., Gan-Or Z; McGill University, Montreal Neurological Institute and Department of Neurology and Neurosurgery, Montréal, QC, Canada.; McGill University, Department of Human Genetics, Montréal, QC, Canada., Yu E; McGill University, Montreal Neurological Institute and Department of Neurology and Neurosurgery, Montréal, QC, Canada.; McGill University, Department of Human Genetics, Montréal, QC, Canada., Liu L; McGill University, Montreal Neurological Institute and Department of Neurology and Neurosurgery, Montréal, QC, Canada.; McGill University, Department of Human Genetics, Montréal, QC, Canada., St Louis EK; Mayo Clinic, Neurology and Medicine, Rochester, MN, USA., Forsberg LK; Mayo Clinic, Neurology and Medicine, Rochester, MN, USA., Fields JA; Mayo Clinic, Neurology and Medicine, Rochester, MN, USA., Ross OA; Mayo Clinic, Neurology and Medicine, Rochester, MN, USA., Huddleston DE; Emory University, Department of Neurology, Atlanta, GA, USA., Bliwise DL; Emory University, Department of Neurology, Atlanta, GA, USA., Avidan AY; University of California Los Angeles, Neurology, Sleep Disorders Center, Los Angeles, CA, USA., Howell MJ; University of Minnesota Medical Center, Department of Neurology, Minneapolis, MN, USA.; Hennepin County Medical Center, Minnesota Regional Sleep Disorders Center, Minneapolis, MN, USA., Schenck CH; University of Minnesota Medical Center, Department of Neurology, Minneapolis, MN, USA., McLeland J; Washington University School of Medicine, Department of Neurology, Saint Louis, MO, USA., Criswell SR; Barrow Neurological Institute, Phoenix, AZ, USA., Videnovic A; Massachusetts General Hospital, Movement Disorders Unit, Division of Sleep Medicine, Boston, MA, USA.; Harvard Medical School, Neurological Clinical Research Institute, Boston, MA, USA., During EH; Stanford University, Psychiatry and Behavioral Sciences, Redwood City, CA, USA.; Stanford University, Neurology and Neurological Sciences, Palo Alto, CA, USA.; Mt Sinai School of Medicine, Department of Neurology, New York, NY, USA., Miglis MG; Stanford University, Psychiatry and Behavioral Sciences, Redwood City, CA, USA.; Stanford University, Neurology and Neurological Sciences, Palo Alto, CA, USA., Shprecher DR; Banner University Medical Center, Department of Neurology, Phoenix, AZ, USA., Lee-Iannotti JK; Banner Sun Health Research Institute, Sun City, AZ, USA., Boeve BF; Mayo Clinic, Neurology and Medicine, Rochester, MN, USA.; NAPS Consortium Co-principal Investigators., Ju YS; Washington University School of Medicine, Department of Neurology, Saint Louis, MO, USA.; NAPS Consortium Co-principal Investigators., Lim MM; Oregon Health and Science University, Department of Neurology, Portland, OR, USA.; Oregon Health and Science University, Department of Behavioral Neuroscience; Department of Pulmonary and Critical Care Medicine; Oregon Institute of Occupational Health Sciences, Portland, OR, USA.; VA Portland Health Care System, Mental Illness Research Education and Clinical Center; Neurology; National Center for Rehabilitative Auditory Research, Portland, OR, USA. |
| مؤلفون مشاركون: | North American Prodromal Synucleinopathy (NAPS) Consortium |
| المصدر: | Sleep [Sleep] 2024 Jun 13; Vol. 47 (6). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | REM Sleep Behavior Disorder*/epidemiology , REM Sleep Behavior Disorder*/physiopathology, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Aged ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/physiopathology ; Synucleinopathies/physiopathology ; Synucleinopathies/epidemiology ; Synucleinopathies/complications ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/physiopathology ; Prodromal Symptoms ; Polysomnography ; Comorbidity ; Autonomic Nervous System Diseases/epidemiology ; Autonomic Nervous System Diseases/physiopathology ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/etiology ; Parkinson Disease/complications ; Parkinson Disease/physiopathology ; Parkinson Disease/epidemiology |
| مستخلص: | Study Objectives: Rapid eye movement sleep behavior disorder (RBD) is strongly associated with phenoconversion to an overt synucleinopathy, e.g. Parkinson's disease (PD), Lewy body dementia, and related disorders. Comorbid traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD)-henceforth "neurotrauma" (NT)-increase the odds of RBD by ~2.5-fold and are associated with an increased rate of service-connected PD in Veterans. Thus, RBD and NT are both independently associated with PD; however, it is unclear how NT influences neurological function in patients with RBD. Methods: Participants ≥18 years with overnight polysomnogram-confirmed RBD were enrolled between 8/2018 to 4/2021 through the North American Prodromal Synucleinopathy Consortium. Standardized assessments for RBD, TBI, and PTSD history, as well as cognitive, motor, sensory, and autonomic function, were completed. This cross-sectional analysis compared cases (n = 24; RBD + NT) to controls (n = 96; RBD), matched for age (~60 years), sex (15% female), and years of education (~15 years). Results: RBD + NT reported earlier RBD symptom onset (37.5 ± 11.9 vs. 52.2 ± 15.1 years of age) and a more severe RBD phenotype. Similarly, RBD + NT reported more severe anxiety and depression, greater frequency of hypertension, and significantly worse cognitive, motor, and autonomic function compared to RBD. No differences in olfaction or color vision were observed. Conclusions: This cross-sectional, matched case:control study shows individuals with RBD + NT have significantly worse neurological measures related to common features of an overt synucleinopathy. Confirmatory longitudinal studies are ongoing; however, these results suggest RBD + NT may be associated with more advanced neurological symptoms related to an evolving neurodegenerative process. (Published by Oxford University Press on behalf of Sleep Research Society (SRS) 2024.) |
| التعليقات: | Comment in: Sleep. 2024 Jun 13;47(6):zsae060. doi: 10.1093/sleep/zsae060. (PMID: 38436612) |
| معلومات مُعتمدة: | P30 AG062677 United States AG NIA NIH HHS; P50 AG016574 United States AG NIA NIH HHS; R34 AG056639 United States AG NIA NIH HHS; U19 AG071754 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Investigator: YS Ju; BF Boeve; RB Postuma; AY Avidan; DL Bliwise; SR Criswell; KM Duff; EH During; JE Elliott; JA Fields; LK Forsberg; JF Gagnon; Z Gan-Or; MJ Howell; DE Huddleston; JK Lee-Iannotti; MM Lim; J Locke; MG Miglis; LE Neilson; RB Postuma; OA Ross; DR Shprecher; EKS Louis; A Videnovic; J McLeland; S Amudson-Huffmaster; N Brushaber; P Choudhury; JW Chung; J De Kam; E Fischbach; A Ekelmans; M Keane; AT Keil; R Kraft; BR Ligman; L Liu; C MacKinnon; D Miner-Rose; S Murphy; C Olivo; A Pelletier; KLM Powers; M Stauder; A Rivera; S Sanchez; R Summers; L Tiegan; L Taylor; P Timm; K Tucker; E Yu; P Tran; D Galasko; E Mignot; C Schenck Keywords: Parkinson’s disease; RBD; REM sleep without atonia; posttraumatic stress disorder; synucleinopathy; trauma-associated sleep disorder; traumatic brain injury |
| تواريخ الأحداث: | Date Created: 20240105 Date Completed: 20240612 Latest Revision: 20240809 |
| رمز التحديث: | 20240809 |
| DOI: | 10.1093/sleep/zsae007 |
| PMID: | 38181205 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-9109 |
|---|---|
| DOI: | 10.1093/sleep/zsae007 |