دورية أكاديمية
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging.
| العنوان: | Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging. |
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| المؤلفون: | Blodgett JM; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada. joanna.blodgett@ucl.ac.uk.; Division of Surgery Interventional Science, Institute of Sport Exercise and Health, University College London, London, UK. joanna.blodgett@ucl.ac.uk., Pérez-Zepeda MU; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada.; Instituto Nacional de Geriatría, Mexico City, Mexico.; Centro de Investigación en Ciencias de La Salud (CICSA), FCS, Universidad Anáhuac México Campus Norte, Huixquilucan, Edo. de México, Lomas Anahuac, Mexico., Godin J; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada., Kehler DS; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada.; School of Physiotherapy, Dalhousie University, Halifax, NS, Canada., Andrew MK; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada., Kirkland S; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada.; Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada., Rockwood K; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada., Theou O; Division of Geriatric Medicine, Dalhousie University and Nova Scotia Health, Halifax, NS, Canada.; School of Physiotherapy, Dalhousie University, Halifax, NS, Canada. |
| المصدر: | GeroScience [Geroscience] 2024 Jun; Vol. 46 (3), pp. 3061-3069. Date of Electronic Publication: 2024 Jan 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cham : Springer International Publishing, [2017]- |
| مواضيع طبية MeSH: | Frailty*/diagnosis, Humans ; Female ; Aged ; Male ; Longitudinal Studies ; Prognosis ; Frail Elderly ; Canada ; Aging ; Biomarkers |
| مستخلص: | The frailty index (FI) uses a deficit accumulation approach to derive a single, comprehensive, and replicable indicator of age-related health status. Yet, many researchers continue to seek a single "frailty biomarker" to facilitate clinical screening. We investigated the prognostic accuracy of 70 individual biomarkers in predicting mortality, comparing each with a composite FI. A total of 29,341 individuals from the comprehensive cohort of the Canadian Longitudinal Study on Aging were included (mean, 59.4 ± 9.9 years; 50.3% female). Twenty-three blood-based biomarkers and 47 test-based biomarkers (e.g., physical, cardiac, cardiology) were examined. Two composite FIs were derived: FI-Blood and FI-Examination. Mortality status was ascertained using provincial vital statistics linkages and contact with next of kin. Areas under the curve were calculated to compare prognostic accuracy across models (i.e., age, sex, biomarker, FI) in predicting mortality. Compared to an age-sex only model, the addition of individual biomarkers demonstrated improved model fit for 24/70 biomarkers (11 blood, 13 test-based). Inclusion of FI-Blood or FI-Examination improved mortality prediction when compared to any of the 70 biomarker-age-sex models. Individual addition of seven biomarkers (walking speed, chair rise, time up and go, pulse, red blood cell distribution width, C-reactive protein, white blood cells) demonstrated an improved fit when added to the age-sex-FI model. FI scores had better mortality risk prediction than any biomarker. Although seven biomarkers demonstrated improved prognostic accuracy when considered alongside an FI score, all biomarkers had worse prognostic accuracy on their own. Rather than a single biomarker test, implementation of routine FI assessment in clinical settings may provide a more accurate and reliable screening tool to identify those at increased risk of adverse outcomes. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | ACD-170302 Canada CIHR; ACD-170302 Canada CIHR |
| فهرسة مساهمة: | Keywords: Biomarkers; CLSA; Frailty; Mortality; Prediction |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240105 Date Completed: 20240415 Latest Revision: 20240722 |
| رمز التحديث: | 20240722 |
| مُعرف محوري في PubMed: | PMC11009196 |
| DOI: | 10.1007/s11357-023-01055-2 |
| PMID: | 38182858 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2509-2723 |
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| DOI: | 10.1007/s11357-023-01055-2 |