دورية أكاديمية
أعرض في EDS

Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity.

التفاصيل البيبلوغرافية
العنوان: Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity.
المؤلفون: Andrade RDS; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP); rssarni@gmail.com., de Souza FIS; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP)., Aranda CS; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP)., Mallozi MC; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP)., Ferreira AC; Department of Pathology. Centro Universitário FMABC., Barreto TLN; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP)., Fonseca FLA; Department of Pathology. Centro Universitário FMABC., Sarni ROS; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP)., Solé D; Department of Pediatrics. Division of Allergy, Clinical Immunology and Rheumatology. Universidade Federal de São Paulo (UNIFESP).
المصدر: Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2024 Jan 01; Vol. 52 (1), pp. 65-70. Date of Electronic Publication: 2024 Jan 01 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: eCollection Cited Medium: Internet ISSN: 1578-1267 (Electronic) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Singapore] : Codon Publications
Original Publication: Madrid : Elsevier España
مواضيع طبية MeSH: Antioxidants* , Dermatitis, Atopic*/epidemiology, Child, Preschool ; Child ; Adolescent ; Humans ; Interleukin-33 ; Copper ; Cross-Sectional Studies ; Vitamins ; Vitamin E ; Vitamin A ; Inflammation ; Patient Acuity ; Vitamin K ; Zinc
مستخلص: Background: Atopic dermatitis (AD) is a relapsing, chronic cutaneous inflammatory disease with onset, in general, in early childhood. Chronic skin inflammation is associated with overproduction of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. Oxidative stress, an imbalance between the production of free radicals and antioxidant defense, results in tissue inflammation due to the upregulation of genes that encode inflammatory cytokines. This condition plays an important role in the pathogenesis of AD.
Objective: To compare the antioxidant defense in children and adolescents with AD with that of healthy individuals and to verify the association of antioxidant defense with disease severity and nutritional status.
Methods: Cross-sectional study that evaluated 48 children and adolescents with AD and 25 controls for nutritional assessment (body mass index z score [BMIZ] and height for age z score [HAZ]) and levels of vitamins A, C, E, and D, zinc (Zn), copper (Cu), antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]), high-sensitivity C-reactive protein (CRP) and interleukin 33 (IL-33).
Results: There was no significant difference in the comparison between AD and control groups for serum levels of vitamins (A, D, C, and E), copper, and antioxidant enzymes. Serum zinc levels were higher in the AD group (β = 24.20; 95% CI 13.95-34.91; P < 0.001) even after adjusting the BMIZ, HAZ, gender, IL-33, and CRP. Children and adolescents with moderate or severe AD compared to mild AD (SCORAD - 36.7±17.4 vs 11.8 ± 3.9; P < 0.001) had lower values of the vitamin E/total lipid ratio (3.68 [0.29;12.63] vs 5.92 [3.27;17.37]; P = 0.013).
Conclusion: Children and adolescents with AD had higher concentrations OF elevated levels of zinc compared to controls, a fact not observed for other biomarkers of antioxidant defense. AD in moderate or severe forms presented lower concentrations of vitamin E, a potent antioxidant fat soluble.
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فهرسة مساهمة: Keywords: Adolescent; Antioxidant Defense; Atopic Dermatitis; Child; Oxidative Stress
المشرفين على المادة: 0 (Antioxidants)
0 (Interleukin-33)
789U1901C5 (Copper)
0 (Vitamins)
1406-18-4 (Vitamin E)
11103-57-4 (Vitamin A)
12001-79-5 (Vitamin K)
J41CSQ7QDS (Zinc)
تواريخ الأحداث: Date Created: 20240108 Date Completed: 20240109 Latest Revision: 20240109
رمز التحديث: 20240109
DOI: 10.15586/aei.v52i1.933
PMID: 38186195
قاعدة البيانات: MEDLINE
الوصف
تدمد:1578-1267
DOI:10.15586/aei.v52i1.933