دورية أكاديمية
Clinical presentation, role of surgery and prognosis in spinal astrocytoma: Cohort study.
| العنوان: | Clinical presentation, role of surgery and prognosis in spinal astrocytoma: Cohort study. |
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| المؤلفون: | Takami H; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Brown DA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Spear JA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Shinya Y; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Burns TC; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Clarke MJ; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Krauss WE; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. |
| المصدر: | World neurosurgery: X [World Neurosurg X] 2023 Dec 09; Vol. 21, pp. 100269. Date of Electronic Publication: 2023 Dec 09 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101747743 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1397 (Electronic) Linking ISSN: 25901397 NLM ISO Abbreviation: World Neurosurg X Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York] : Elsevier Inc., [2019]- |
| مستخلص: | Spinal astrocytoma is a rare neoplasm with discouraging prognosis, which accounts for 6-8 % of total intramedullary spinal tumors. As this is a rare entity, details of the clinical and molecular features have not been fully unraveled. We evaluated the radiologic findings, perioperative clinical presentation, histopathological features and treatment response in a single institution series of 37 consecutive cases of spinal astrocytomas (WHO grades 1 to 4). We identified 8, 16, 8, and 5 patients with grade 1, 2, 3, and 4 lesions, respectively, from 1988 to 2017. Peak ages were youngest in grade 1, followed in order by grades 4, 3 and 2. Whereas all cases of grade 1 and 4 enhanced with contrast, less than half of the cases of grade 2 tumors enhanced (44 %). Grade 3 tumors had a higher rate of multiplicity at presentation (50 %). A concomitant brain lesion at presentation was present in 14 % and 43 % of grade 2 and 3 lesions, respectively. Progression-free and overall survival were worse in grades 3 and 4 compared to grade 2 lesions but no significant difference was observed between grade 3 and 4. Many patients (16-of-36) experienced new neurological deficits postoperatively regardless of grade. Most patients (88 %) required postoperative rehabilitation, and 61 % were not discharged to home. Discharge destination closely correlated with age ( p = 0.002). These clinical findings may be useful in understanding the clinical phenotype and improving the management of this rare disease. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
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| فهرسة مساهمة: | Keywords: Astrocytoma; Glioma; Intramedullary tumor; Prognosis; Spinal tumor |
| تواريخ الأحداث: | Date Created: 20240108 Latest Revision: 20240109 |
| رمز التحديث: | 20240109 |
| مُعرف محوري في PubMed: | PMC10767261 |
| DOI: | 10.1016/j.wnsx.2023.100269 |
| PMID: | 38187503 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2590-1397 |
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| DOI: | 10.1016/j.wnsx.2023.100269 |