دورية أكاديمية
Clinical presentation, role of surgery and prognosis in spinal astrocytoma: Cohort study.
العنوان: | Clinical presentation, role of surgery and prognosis in spinal astrocytoma: Cohort study. |
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المؤلفون: | Takami H; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Brown DA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Spear JA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Shinya Y; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Burns TC; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Clarke MJ; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA., Krauss WE; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. |
المصدر: | World neurosurgery: X [World Neurosurg X] 2023 Dec 09; Vol. 21, pp. 100269. Date of Electronic Publication: 2023 Dec 09 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101747743 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1397 (Electronic) Linking ISSN: 25901397 NLM ISO Abbreviation: World Neurosurg X Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] : Elsevier Inc., [2019]- |
مستخلص: | Spinal astrocytoma is a rare neoplasm with discouraging prognosis, which accounts for 6-8 % of total intramedullary spinal tumors. As this is a rare entity, details of the clinical and molecular features have not been fully unraveled. We evaluated the radiologic findings, perioperative clinical presentation, histopathological features and treatment response in a single institution series of 37 consecutive cases of spinal astrocytomas (WHO grades 1 to 4). We identified 8, 16, 8, and 5 patients with grade 1, 2, 3, and 4 lesions, respectively, from 1988 to 2017. Peak ages were youngest in grade 1, followed in order by grades 4, 3 and 2. Whereas all cases of grade 1 and 4 enhanced with contrast, less than half of the cases of grade 2 tumors enhanced (44 %). Grade 3 tumors had a higher rate of multiplicity at presentation (50 %). A concomitant brain lesion at presentation was present in 14 % and 43 % of grade 2 and 3 lesions, respectively. Progression-free and overall survival were worse in grades 3 and 4 compared to grade 2 lesions but no significant difference was observed between grade 3 and 4. Many patients (16-of-36) experienced new neurological deficits postoperatively regardless of grade. Most patients (88 %) required postoperative rehabilitation, and 61 % were not discharged to home. Discharge destination closely correlated with age ( p = 0.002). These clinical findings may be useful in understanding the clinical phenotype and improving the management of this rare disease. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
References: | Radiographics. 2004 Nov-Dec;24(6):1693-708. (PMID: 15537977) Neurosurgery. 2019 May 1;84(5):1072-1081. (PMID: 29718432) Asian Spine J. 2016 Aug;10(4):748-54. (PMID: 27559457) J Neurosurg. 1992 Sep;77(3):355-9. (PMID: 1506881) J Neurooncol. 2020 Jan;146(2):303-310. (PMID: 31873874) J Neurosurg. 1981 Mar;54(3):323-30. (PMID: 7463133) Cancer Cell. 2012 Oct 16;22(4):425-37. (PMID: 23079654) Neurosurgery. 2008 Jul;63(1):55-60; discussion 60-1. (PMID: 18728568) Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):727-33. (PMID: 18687533) J Neurosurg. 1985 Nov;63(5):669-75. (PMID: 4056869) Int J Radiat Oncol Biol Phys. 2000 Oct 1;48(3):837-42. (PMID: 11020582) Cancer. 2003 Aug 1;98(3):554-61. (PMID: 12879473) World Neurosurg. 2016 Feb;86:341-8.e1-3. (PMID: 26348566) N Engl J Med. 2005 Mar 10;352(10):987-96. (PMID: 15758009) World Neurosurg. 2017 Oct;106:113-119. (PMID: 28377242) Spine (Phila Pa 1976). 2012 May 20;37(12):E727-35. (PMID: 22609727) Spine (Phila Pa 1976). 2014 Apr 1;39(7):533-40. (PMID: 24384651) Neurosurg Focus. 2021 May;50(5):E22. (PMID: 33932931) |
فهرسة مساهمة: | Keywords: Astrocytoma; Glioma; Intramedullary tumor; Prognosis; Spinal tumor |
تواريخ الأحداث: | Date Created: 20240108 Latest Revision: 20240109 |
رمز التحديث: | 20240109 |
مُعرف محوري في PubMed: | PMC10767261 |
DOI: | 10.1016/j.wnsx.2023.100269 |
PMID: | 38187503 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2590-1397 |
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DOI: | 10.1016/j.wnsx.2023.100269 |