دورية أكاديمية
أعرض في EDS

Phytochemical profile and anti-inflammatory activity of the hull of γ-irradiated wheat mutant lines ( Triticum aestivum L.).

التفاصيل البيبلوغرافية
العنوان: Phytochemical profile and anti-inflammatory activity of the hull of γ-irradiated wheat mutant lines ( Triticum aestivum L.).
المؤلفون: Park J; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea., Kil YS; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea., Ryoo GH; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea., Jin CH; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea., Hong MJ; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea., Kim JB; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea., Jung CH; Jeonju AgroBio-Materials Institute, Jeonju-si, Jeollabuk-do, Republic of Korea., Nam JW; College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea., Han AR; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, Republic of Korea.
المصدر: Frontiers in nutrition [Front Nutr] 2023 Dec 22; Vol. 10, pp. 1334344. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]-
مستخلص: Wheat ( Triticum aestivum Linn.; Poaceae) is the second most cultivated food crop among all global cereal crop production. The high carbohydrate content of its grains provides energy, multiple nutrients, and dietary fiber. After threshing, a substantial amount of wheat hull is produced, which serves as the non-food component of wheat. For the valorization of these by-products as a new resource from which functional components can be extracted, the hull from the seeds of cultivated wheat mutant lines bred after γ-irradiation were collected. Untargeted metabolite analysis of the hull of the original cultivar (a crossbreeding cultivar., Woori-mil × D-7) and its 983 mutant lines were conducted using ultra-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry technique. A total of 55 molecules were tentatively identified, including 21 compounds found in the Triticum species for the first time and 13 compounds not previously described. Among them, seven flavonolignans with a diastereomeric structure, isolated as a single compound from the hull of T. aestivum in our previous study, were used as the standards in the metabolite analysis. The differences in their collision cross-section values were shown to contribute to the clear distinction between tricine-lignan stereoisomers. To select functionally active agents with anti-inflammatory activity among the identified compounds, the wheat hull samples were evaluated for their inhibitory effect on nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells. As a result of multivariate analysis based on the results of chemical and biological profiles of the wheat hull samples, 10 metabolites were identified as key markers, contributing to the distinction between active and inactive mutant lines. Considering that one of the four key markers attributed to anti-inflammatory activity has been identified to be a flavonolignan, the wheat hull could be a valuable source of diverse tricin-lignan type compounds and used as a natural health-promoting product in food supplements.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Park, Kil, Ryoo, Jin, Hong, Kim, Jung, Nam and Han.)
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فهرسة مساهمة: Keywords: Triticum aestivum; UPLC-ESI-QTOF-MS; anti-inflammatory; flavonolignan; metabolomics; wheat hull
تواريخ الأحداث: Date Created: 20240108 Latest Revision: 20240109
رمز التحديث: 20240109
مُعرف محوري في PubMed: PMC10771830
DOI: 10.3389/fnut.2023.1334344
PMID: 38188878
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-861X
DOI:10.3389/fnut.2023.1334344