دورية أكاديمية
Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study.
| العنوان: | Longitudinal patterns in indeterminate HIV rapid antibody test results: a population-based, prospective cohort study. |
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| المؤلفون: | Hunt JH; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Mwinnyaa G; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Patel EU; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Grabowski MK; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Rakai Health Sciences Program, Kalisizo, Uganda., Kagaayi J; Rakai Health Sciences Program, Kalisizo, Uganda., Gray RH; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Ssekasanvu J; Rakai Health Sciences Program, Kalisizo, Uganda., Wawer MJ; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Kigozi G; Rakai Health Sciences Program, Kalisizo, Uganda., Chang LW; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Rakai Health Sciences Program, Kalisizo, Uganda., Kalibbala S; Rakai Health Sciences Program, Kalisizo, Uganda., Nakalanzi M; Rakai Health Sciences Program, Kalisizo, Uganda., Ndyanabo A; Rakai Health Sciences Program, Kalisizo, Uganda., Quinn TC; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Serwadda D; Rakai Health Sciences Program, Kalisizo, Uganda.; Makerere University, Kampala, Uganda., Reynolds SJ; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Rakai Health Sciences Program, Kalisizo, Uganda., Galiwango RM; Rakai Health Sciences Program, Kalisizo, Uganda., Laeyendecker O; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
| المصدر: | Microbiology spectrum [Microbiol Spectr] 2024 Feb 06; Vol. 12 (2), pp. e0325323. Date of Electronic Publication: 2024 Jan 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ASM Press, 2013- |
| مواضيع طبية MeSH: | HIV Infections*/epidemiology, Male ; Humans ; Female ; Cohort Studies ; Prospective Studies ; Longitudinal Studies ; Uganda/epidemiology ; HIV Testing |
| مستخلص: | Rapid HIV tests are critical to HIV surveillance and universal testing and treatment programs. We assessed longitudinal patterns in indeterminate HIV rapid test results in an African population-based cohort. Prospective HIV rapid antibody test results, defined by two parallel rapid tests, among participants aged 15-49 years from three survey rounds of the Rakai Community Cohort Study, Uganda, from 2013 to 2018, were assessed. An indeterminate result was defined as any weak positive result or when one test was negative and the other was positive. A total of 31,405 participants contributed 54,459 person-visits, with 15,713 participants contributing multiple visits and 7,351 participants contributing 3 visits. The prevalence of indeterminate results was 2.7% (1,490/54,469). Of the participants with multiple visits who initially tested indeterminate ( n = 591), 40.4% were negative, 18.6% were positive, and 41.0% were indeterminate at the subsequent visit. Of the participants with two consecutive indeterminate results who had a third visit ( n = 67), 20.9% were negative, 9.0% were positive, and 70.2% remained indeterminate. Compared to a prior negative result, a prior indeterminate result was strongly associated with a subsequent indeterminate result [adjusted prevalence ratio, 23.0 (95% CI = 20.0-26.5)]. Compared to men, women were more likely to test indeterminate than negative [adjusted odds ratio, 2.3 (95% CI = 2.0-2.6)]. Indeterminate rapid HIV test results are highly correlated within an individual and 0.6% of the population persistently tested indeterminate over the study period. A substantial fraction of people with an indeterminate result subsequently tested HIV positive at the next visit, underscoring the importance of follow-up HIV testing protocols.IMPORTANCERapid HIV tests are a critical tool for expanding HIV testing and treatment to end the HIV epidemic. The interpretation and management of indeterminate rapid HIV test results pose a unique challenge for connecting all people living with HIV to the necessary care and treatment. Indeterminate rapid HIV test results are characterized by any weak positive result or discordant results (when one test is negative and the other is positive). We systematically tested all participants of a Ugandan population-based, longitudinal cohort study regardless of prior test results or HIV status to quantify longitudinal patterns in rapid HIV test results. We found that a substantial fraction (>15%) of participants with indeterminate rapid test results subsequently tested positive upon follow-up testing at the next visit. Our findings demonstrate the importance of follow-up HIV testing protocols for indeterminate rapid HIV test results. Competing Interests: The authors declare no conflict of interest. |
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| معلومات مُعتمدة: | U01 AI100031 United States AI NIAID NIH HHS; U01 AI075115 United States AI NIAID NIH HHS; P30 AI094189 United States AI NIAID NIH HHS; K01 AI125086 United States AI NIAID NIH HHS; R01 AI110324 United States AI NIAID NIH HHS; R01 AI102939 United States AI NIAID NIH HHS; T32 AI102623 United States AI NIAID NIH HHS; R01 HD050180 United States HD NICHD NIH HHS; R01 MH107275 United States MH NIMH NIH HHS; F31 DA054849 United States DA NIDA NIH HHS; R01 AI143333 United States AI NIAID NIH HHS; R01 HD070769 United States HD NICHD NIH HHS; UM1 AI068613 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: HIV diagnostics; indeterminate; point of care testing; rapid test; serology |
| تواريخ الأحداث: | Date Created: 20240108 Date Completed: 20240208 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10845946 |
| DOI: | 10.1128/spectrum.03253-23 |
| PMID: | 38189332 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2165-0497 |
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| DOI: | 10.1128/spectrum.03253-23 |