دورية أكاديمية
Expanded Application of Piper nigrum : Guided Isolation of Alkaloids with Inhibitory Activities of AChE/BuChE and Aβ Aggregation.
| العنوان: | Expanded Application of Piper nigrum : Guided Isolation of Alkaloids with Inhibitory Activities of AChE/BuChE and Aβ Aggregation. |
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| المؤلفون: | Du NN; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China., Xu ZY; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China., Lin B; Shenyang Pharmaceutical University Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China., Bai M; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China., Huang XX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China., Song SJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province, Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jan 24; Vol. 72 (3), pp. 1607-1617. Date of Electronic Publication: 2024 Jan 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Piper nigrum*/chemistry , Alkaloids*/chemistry , Piper*/chemistry, Plant Extracts/chemistry ; Chromatography, Liquid ; Tandem Mass Spectrometry |
| مستخلص: | Piper nigrum is a popular crop that can be used as seasoning or as an additive but its active ingredients also have an effect on the nervous system. Nineteen new amide alkaloids ( 1a / 1b , 2 - 5 , 6a / 6b , 7 , 8a / 8b , 9 , 10a / 10b , 11a - 11b , 12 - 14 ) were isolated from P. nigrum , guided by inhibitory activity of AChE and LC-MS/MS based on GNPS. The configurations were determined by extensive spectral analysis, Bulkiness rule, and NMR calculations. The inhibitory activities of AChE/BuChE and Aβ aggregation were tested, and the results showed compounds 2 , 7 , and 12 had significant inhibitory activities. These components were identified in the crude fraction and their relative quantities were tested, which suggested that compound 2 was the index component in the active site from P. nigrum . |
| فهرسة مساهمة: | Keywords: amide alkaloids; inhibitory activities of AChE/BuChE and Aβ aggregation; piper nigrum L. |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Alkaloids) |
| تواريخ الأحداث: | Date Created: 20240108 Date Completed: 20240125 Latest Revision: 20240125 |
| رمز التحديث: | 20240125 |
| DOI: | 10.1021/acs.jafc.3c07740 |
| PMID: | 38190504 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.3c07740 |