دورية أكاديمية
Childhood mixed connective tissue disease at disease onset: Evidence from a systematic review.
| العنوان: | Childhood mixed connective tissue disease at disease onset: Evidence from a systematic review. |
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| المؤلفون: | Terminiello A; Department of Health Sciences, University of Florence, Florence, Italy. Electronic address: alberto.terminiello@unifi.it., Marrani E; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy. Electronic address: edoardo.marrani@meyer.it., Pagnini I; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Maccora I; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy; NEUROFARBA Department, University of Florence, Florence, Italy., Maniscalco V; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Rumeileh SA; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Mastrolia MV; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy., Simonini G; Rheumatology Unit, ERN-ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy; NEUROFARBA Department, University of Florence, Florence, Italy. |
| المصدر: | Autoimmunity reviews [Autoimmun Rev] 2024 Apr; Vol. 23 (4), pp. 103513. Date of Electronic Publication: 2024 Jan 06. |
| نوع المنشور: | Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | Mixed Connective Tissue Disease*/diagnosis, Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Male ; Age of Onset |
| مستخلص: | Objective: Childhood Mixed Connective Tissue Disease (cMCTD) is the rarest pediatric connective tissue disease that includes features of systemic lupus erythematosus, polymyositis/dermatomyositis, juvenile idiopathic arthritis, and systemic sclerosis, identified by Sharp in 1972 and whose diagnosis remains challenging. This systematic review aims to identify clinical features at the onset of cMCTD and manifestations not currently included into the available diagnostic criteria. Methods: A systematic literature review was performed in accordance with PRISMA guidelines 2020 using bibliographic databases: MEDLINE via PubMed and EMBASE. Eligibility Criteria: patients diagnosed with MCTD with onset before 18 years. Studies Included: registries, retrospective and prospective cohort studies, case series and reports with analysis of data on signs and symptoms of presentation. Results: 39 articles were included (215 subjects, 82.5% female), mean age of 141 months (± 41 months DS, range 2.5-204). The most used criteria for the diagnosis of MCTD were the Kasukawa criteria (54.5%). The clinical manifestations described at onset were Raynaud's phenomenon (69.7%), arthritis (60.9%), muscular involvement (53.5%), dermatological signs (39.5%), swollen fingers or hands (29.3%), arthralgias (25.6%), fever (22.3%), lung involvement (14.4%), sclerodactily (13.5%), lymphadenopathy (10.7%) serositis (10.2%), esophageal involvement (6.9%), nervous system involvement (6.9%), xeroftalmia (3.7%), xerostomia (3.7%), hepatosplenomegaly (2.8%), cardiac involvement (2.8%), hepatitis (2.3%), parotiditis (2.3%), Hashimoto's thyroiditis (0.9%), ocular involvement (0.9%). Conclusions: The data from this systematic review suggest great heterogeneity of the clinical presentation of cMCTD for which there are no validated diagnostic criteria that may suggest a new diagnostic approach to allow earlier or more accurate diagnosis in the future. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Dermatomyositis; Juvenile idiopathic arthritis; Lupus erythematosus, systemic; Mixed connective tissue disease; Pediatric onset; Systemic sclerosis |
| تواريخ الأحداث: | Date Created: 20240108 Date Completed: 20240512 Latest Revision: 20240514 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1016/j.autrev.2023.103513 |
| PMID: | 38191065 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-0183 |
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| DOI: | 10.1016/j.autrev.2023.103513 |