دورية أكاديمية
أعرض في EDS

Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol.

التفاصيل البيبلوغرافية
العنوان: Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol.
المؤلفون: Álvarez Troncoso J; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain jorge.alvarez.troncoso@gmail.com., Soto Abánades C; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain.; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain., Robles-Marhuenda Á; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain., Alcolea Batres S; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain., Fernández Velilla Peña M; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Radiodiagnóstico, Hospital Universitario La Paz, Madrid, Spain., Jiménez Valero S; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Sorriguieta Torre R; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain., Rios-Blanco JJ; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain.; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.
المصدر: RMD open [RMD Open] 2024 Jan 08; Vol. 10 (1). Date of Electronic Publication: 2024 Jan 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Publishing Group, [2015]-
مواضيع طبية MeSH: Hypertension, Pulmonary*/diagnosis , Hypertension, Pulmonary*/epidemiology , Hypertension, Pulmonary*/etiology , Serositis* , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/epidemiology, Humans ; Female ; Male ; Prevalence ; Prospective Studies ; Echocardiography ; Biomarkers
مستخلص: Background: Systemic lupus erythematosus (SLE) significantly affects the lungs and heart, and pulmonary hypertension (PH) is a severe manifestation that leads to considerable morbidity and mortality.
Objectives: We aimed to determine the prevalence and risk factors of probable SLE-PH, assess the main echocardiographic predictors and develop a potential screening strategy.
Methods: A prospective single-centre study was conducted on 201 patients with SLE who underwent transthoracic echocardiography. Patients meeting PH criteria were referred for right heart catheterisation (RHC).
Results: Among patients, 88.56% were women, 85.57% were of Spanish origin and 43.78% had structural heart disease. Out of these, 16 (7.96%) had intermediate or high probability criteria for PH according to European Society of Cardiology (ESC) 2022. Six RHCs confirmed PH with a prevalence of 2.99% for SLE-PH and 1.99% for SLE-pulmonary arterial hypertension (PAH).
Key Risk Factors: Key risk factors included age, cardiorespiratory symptoms, serositis, anti-Ro, cardiac biomarkers and altered pulmonary function tests (PFTs). PH was linked to a higher Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SDI) (mean SDI 4.75 vs 2.05, p<0.001) and increased mortality risk in a 2-year follow-up (12.50% vs 1.08%, p=0.002).
Conclusion: In our cohort, 7.96% of patients with SLE had an intermediate or high PH probability. By RHC, six patients (2.99%) met the ESC/European Respiratory Society criteria for PH and four (1.99%) for PAH. The main risk factors were older age, cardiorespiratory symptoms, serositis, anti-Ro, cardiac biomarkers and altered PFTs. PH was a severe SLE complication, suggesting the need for earlier diagnosis through data-driven screening to reduce associated morbidity and mortality.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: cardiovascular diseases; hypertension; lupus erythematosus, systemic; risk factors; ultrasonography
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240108 Date Completed: 20240110 Latest Revision: 20240126
رمز التحديث: 20240126
مُعرف محوري في PubMed: PMC10806459
DOI: 10.1136/rmdopen-2023-003674
PMID: 38191213
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-5933
DOI:10.1136/rmdopen-2023-003674