دورية أكاديمية
Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol.
العنوان: | Prevalence, risk factors and echocardiographic predictors of pulmonary hypertension in systemic lupus erythematosus: towards a screening protocol. |
---|---|
المؤلفون: | Álvarez Troncoso J; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain jorge.alvarez.troncoso@gmail.com., Soto Abánades C; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain.; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain., Robles-Marhuenda Á; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain., Alcolea Batres S; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain., Fernández Velilla Peña M; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Radiodiagnóstico, Hospital Universitario La Paz, Madrid, Spain., Jiménez Valero S; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain.; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Sorriguieta Torre R; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain., Rios-Blanco JJ; Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario La Paz, Madrid, Spain.; GRUHPAZ, Grupo de Hipertensión Pulmonar, Hospital Universitario La Paz, Madrid, Spain. |
المصدر: | RMD open [RMD Open] 2024 Jan 08; Vol. 10 (1). Date of Electronic Publication: 2024 Jan 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BMJ Publishing Group, [2015]- |
مواضيع طبية MeSH: | Hypertension, Pulmonary*/diagnosis , Hypertension, Pulmonary*/epidemiology , Hypertension, Pulmonary*/etiology , Serositis* , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/epidemiology, Humans ; Female ; Male ; Prevalence ; Prospective Studies ; Echocardiography ; Biomarkers |
مستخلص: | Background: Systemic lupus erythematosus (SLE) significantly affects the lungs and heart, and pulmonary hypertension (PH) is a severe manifestation that leads to considerable morbidity and mortality. Objectives: We aimed to determine the prevalence and risk factors of probable SLE-PH, assess the main echocardiographic predictors and develop a potential screening strategy. Methods: A prospective single-centre study was conducted on 201 patients with SLE who underwent transthoracic echocardiography. Patients meeting PH criteria were referred for right heart catheterisation (RHC). Results: Among patients, 88.56% were women, 85.57% were of Spanish origin and 43.78% had structural heart disease. Out of these, 16 (7.96%) had intermediate or high probability criteria for PH according to European Society of Cardiology (ESC) 2022. Six RHCs confirmed PH with a prevalence of 2.99% for SLE-PH and 1.99% for SLE-pulmonary arterial hypertension (PAH). Key Risk Factors: Key risk factors included age, cardiorespiratory symptoms, serositis, anti-Ro, cardiac biomarkers and altered pulmonary function tests (PFTs). PH was linked to a higher Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index (SDI) (mean SDI 4.75 vs 2.05, p<0.001) and increased mortality risk in a 2-year follow-up (12.50% vs 1.08%, p=0.002). Conclusion: In our cohort, 7.96% of patients with SLE had an intermediate or high PH probability. By RHC, six patients (2.99%) met the ESC/European Respiratory Society criteria for PH and four (1.99%) for PAH. The main risk factors were older age, cardiorespiratory symptoms, serositis, anti-Ro, cardiac biomarkers and altered PFTs. PH was a severe SLE complication, suggesting the need for earlier diagnosis through data-driven screening to reduce associated morbidity and mortality. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
References: | Am J Respir Crit Care Med. 2009 Apr 1;179(7):615-21. (PMID: 19164700) Eur Respir Rev. 2011 Dec;20(122):277-86. (PMID: 22130821) Int J Cardiovasc Imaging. 2018 May;34(5):695-700. (PMID: 29230598) Eur Heart J Suppl. 2019 Dec;21(Suppl K):K9-K20. (PMID: 31857796) J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D34-41. (PMID: 24355639) Eur Heart J. 2016 Jan 1;37(1):67-119. (PMID: 26320113) Ann Rheum Dis. 2019 Jun;78(6):736-745. (PMID: 30926722) Rheumatol Int. 2013 May;33(5):1211-7. (PMID: 22983159) Int J Cardiol. 2017 Dec 15;249:418. (PMID: 29121747) Cardiol Young. 2021 Oct;31(10):1619-1624. (PMID: 33682659) Clin Dev Immunol. 2012;2012:854941. (PMID: 22489252) Front Immunol. 2021 Jul 15;12:658341. (PMID: 34335565) Pulm Circ. 2011 Apr-Jun;1(2):160-81. (PMID: 22034604) Autoimmun Rev. 2016 Mar;15(3):250-7. (PMID: 26640159) Eur Heart J. 2022 Oct 11;43(38):3618-3731. (PMID: 36017548) Rheumatology (Oxford). 2022 May 30;61(6):2450-2456. (PMID: 34605890) Chest. 2011 May;139(5):988-993. (PMID: 20864617) Chest. 2018 Jan;153(1):143-151. (PMID: 28851621) J Rheumatol. 2016 Feb;43(2):323-9. (PMID: 26669915) Echo Res Pract. 2018 Sep;5(3):G11-G24. (PMID: 30012832) Eur Respir Rev. 2012 Mar 1;21(123):8-18. (PMID: 22379169) Heart. 2011 Apr;97(8):612-22. (PMID: 21357375) |
فهرسة مساهمة: | Keywords: cardiovascular diseases; hypertension; lupus erythematosus, systemic; risk factors; ultrasonography |
المشرفين على المادة: | 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20240108 Date Completed: 20240110 Latest Revision: 20240126 |
رمز التحديث: | 20240126 |
مُعرف محوري في PubMed: | PMC10806459 |
DOI: | 10.1136/rmdopen-2023-003674 |
PMID: | 38191213 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2056-5933 |
---|---|
DOI: | 10.1136/rmdopen-2023-003674 |