دورية أكاديمية
أعرض في EDS

Distinct mesenchymal cell states mediate prostate cancer progression.

التفاصيل البيبلوغرافية
العنوان: Distinct mesenchymal cell states mediate prostate cancer progression.
المؤلفون: Pakula H; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Omar M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, New York, NY, 10021, USA., Carelli R; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Pederzoli F; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Fanelli GN; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.; Department of Laboratory Medicine, Pisa University Hospital, Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy., Pannellini T; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Socciarelli F; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Van Emmenis L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Rodrigues S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Fidalgo-Ribeiro C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Nuzzo PV; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Brady NJ; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Dinalankara W; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Jere M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Valencia I; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Saladino C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Stone J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Unkenholz C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Garner R; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Alexanderani MK; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Khani F; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., de Almeida FN; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA., Abate-Shen C; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Department of Urology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA., Greenblatt MB; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Rickman DS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Barbieri CE; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, New York, NY, 10021, USA.; Department of Urology, Weill Cornell Medicine, New York, NY, 10021, USA., Robinson BD; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, New York, NY, 10021, USA.; Department of Urology, Weill Cornell Medicine, New York, NY, 10021, USA., Marchionni L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. mloda@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Belfer Research Building, 413 East 69th Street, New York, NY, 10021, USA. mloda@med.cornell.edu.; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Ave, Boston, MA, 02215, USA. mloda@med.cornell.edu.; University of Oxford, Nuffield Department of Surgical Sciences, Oxford, UK. mloda@med.cornell.edu.
المصدر: Nature communications [Nat Commun] 2024 Jan 08; Vol. 15 (1), pp. 363. Date of Electronic Publication: 2024 Jan 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Prostatic Neoplasms*/genetics , Mesenchymal Stem Cells*, Humans ; Male ; Animals ; Mice ; Prostate ; Stromal Cells ; Cell Differentiation ; Tumor Microenvironment/genetics
مستخلص: In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular changes in tumor stroma that influence PCa progression and metastasis. Analyzing mesenchymal cells from four genetically engineered mouse models (GEMMs) and correlating these findings with human tumors, we identify eight stromal cell populations with distinct transcriptional identities consistent across both species. Notably, stromal signatures in advanced mouse disease reflect those in human bone metastases, highlighting periostin's role in invasion and differentiation. From these insights, we derive a gene signature that predicts metastatic progression in localized disease beyond traditional Gleason scores. Our results illuminate the critical influence of stromal dynamics on PCa progression, suggesting new prognostic tools and therapeutic targets.
(© 2024. The Author(s).)
التعليقات: Update of: bioRxiv. 2023 Apr 01;:. (PMID: 37034687)
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معلومات مُعتمدة: R01 CA173481 United States CA NCI NIH HHS; R01 CA200859 United States CA NCI NIH HHS; T32 CA260293 United States CA NCI NIH HHS; P01 CA265768 United States CA NCI NIH HHS; P50 CA211024 United States CA NCI NIH HHS; R01 CA183929 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20240108 Date Completed: 20240110 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10774315
DOI: 10.1038/s41467-023-44210-1
PMID: 38191471
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-44210-1