دورية أكاديمية
Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study.
| العنوان: | Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study. |
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| المؤلفون: | Dawson H; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Bokhorst JM; Department of Pathology, Radboudumc, Nijmegen, the Netherlands., Studer L; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.; Institute of Artificial Intelligence and Complex Systems, University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland., Vieth M; Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany., Oguz Erdogan AS; Department of Pathology, Radboudumc, Nijmegen, the Netherlands., Kus Öztürk S; Department of Pathology, Radboudumc, Nijmegen, the Netherlands., Kirsch R; Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Brockmoeller S; Pathology and Data Analytics, Leeds Institute of Medical Research at St. James's School of Medicine, Leeds, UK., Cathomas G; Institute of Pathology, Kantonsspital Baselland, Liestal, Switzerland., Buslei R; Institut und Praxis für Pathologie, Neuropathologie, Molekulare Diagnostik und Zytologie, Sozialstiftung Bamberg, Bamberg, Germany., Fink D; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA., Roumet M; Clinical Trials Unit, University of Bern, Bern, Switzerland., Zlobec I; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., van der Laak J; Department of Pathology, Radboudumc, Nijmegen, the Netherlands., Nagtegaal ID; Department of Pathology, Radboudumc, Nijmegen, the Netherlands., Lugli A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland. |
| المصدر: | United European gastroenterology journal [United European Gastroenterol J] 2024 Apr; Vol. 12 (3), pp. 299-308. Date of Electronic Publication: 2024 Jan 09. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 101606807 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-6414 (Electronic) Linking ISSN: 20506406 NLM ISO Abbreviation: United European Gastroenterol J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [London] : Wiley Original Publication: London : Sage Publications, [2013]- |
| مواضيع طبية MeSH: | Artificial Intelligence* , Colorectal Neoplasms*/surgery , Colorectal Neoplasms*/pathology, Humans ; Retrospective Studies ; Lymphatic Metastasis ; Neoplasm Recurrence, Local/epidemiology |
| مستخلص: | Background: The International Collaboration on Cancer Reporting proposes histological tumour type, lymphovascular invasion, tumour grade, perineural invasion, extent, and dimensions of invasion as risk factors for lymph node metastases and tumour progression in completely endoscopically resected pT1 colorectal cancer (CRC). Objective: The aim of the study was to propose a predictive and reliable score to optimise the clinical management of endoscopically resected pT1 CRC patients. Methods: This multi-centric, retrospective International Budding Consortium (IBC) study included an international pT1 CRC cohort of 565 patients. All cases were reviewed by eight expert gastrointestinal pathologists. All risk factors were reported according to international guidelines. Tumour budding and immune response (CD8+ T-cells) were assessed with automated models using artificial intelligence. We used the information on risk factors and least absolute shrinkage and selection operator logistic regression to develop a prediction model and generate a score to predict the occurrence of lymph node metastasis or cancer recurrence. Results: The IBC prediction score included the following parameters: lymphovascular invasion, tumour buds, infiltration depth and tumour grade. The score has an acceptable discrimination power (area under the curve of 0.68 [95% confidence intervals (CI) 0.61-0.75]; 0.64 [95% CI 0.57-0.71] after internal validation). At a cut-off of 6.8 points to discriminate high-and low-risk patients, the score had a sensitivity and specificity of 0.9 [95% CI 0.8-0.95] and 0.26 [95% 0.22, 0.3], respectively. Conclusion: The IBC score is based on well-established risk factors and is a promising tool with clinical utility to support the management of pT1 CRC patients. (© 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.) |
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| معلومات مُعتمدة: | KFS-4108-02-2017 Swiss Cancer Society; KWF KUN2017-10602 Dutch Cancer Society |
| فهرسة مساهمة: | Keywords: CRC; colorectal cancer; early; grade; histology; lymph node metastases; lymphovascular invasion; pT1; prediction; recurrence |
| تواريخ الأحداث: | Date Created: 20240109 Date Completed: 20240416 Latest Revision: 20240501 |
| رمز التحديث: | 20240502 |
| مُعرف محوري في PubMed: | PMC11017758 |
| DOI: | 10.1002/ueg2.12521 |
| PMID: | 38193866 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2050-6414 |
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| DOI: | 10.1002/ueg2.12521 |