دورية أكاديمية
أعرض في EDS

IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.

التفاصيل البيبلوغرافية
العنوان: IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
المؤلفون: Haslund-Gourley BS; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Woloszczuk K; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Hou J; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Connors J; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Cusimano G; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Bell M; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Taramangalam B; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Fourati S; Emory University, Atlanta, GA, USA., Mege N; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Bernui M; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Altman MC; Benaroya Research Institute, Seattle, WA, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., van Bakel H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Maecker HT; Stanford University, Stanford, CA, USA., Rouphael N; Emory University, Atlanta, GA, USA., Diray-Arce J; Clinical & Data Coordinating Center (CDCC); Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA., Wigdahl B; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Kutzler MA; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Cairns CB; Drexel University/Tower Health Hospital, Philadelphia, PA, USA., Haddad EK; Drexel University/Tower Health Hospital, Philadelphia, PA, USA. ee336@drexel.edu., Comunale MA; Drexel University/Tower Health Hospital, Philadelphia, PA, USA. mc375@drexel.edu.
مؤلفون مشاركون: IMPACC Network
المصدر: Nature communications [Nat Commun] 2024 Jan 09; Vol. 15 (1), pp. 404. Date of Electronic Publication: 2024 Jan 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: COVID-19*, Humans ; Glycosylation ; SARS-CoV-2 ; Glycosyltransferases ; Complement System Proteins ; Immunoglobulin M
مستخلص: The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis of IgM N-glycosylation from healthy controls and hospitalized coronavirus disease 2019 (COVID-19) patients reveals increased high-mannose and sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific immunoglobulin N-glycan profiles. Moreover, the degree of total IgM mannosylation and sialylation correlate significantly with markers of disease severity. We link the changes of IgM N-glycosylation with the expression of Golgi glycosyltransferases. Lastly, we observe antigen-specific IgM antibody-dependent complement deposition is elevated in severe COVID-19 patients and modulated by exoglycosidase digestion. Taken together, this work links the IgM N-glycosylation with COVID-19 severity and highlights the need to understand IgM glycosylation and downstream immune function during human disease.
(© 2024. The Author(s).)
التعليقات: Update of: Res Sq. 2023 Jun 02:rs.3.rs-2939468. doi: 10.21203/rs.3.rs-2939468/v1. (PMID: 37398192)
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المشرفين على المادة: EC 2.4.- (Glycosyltransferases)
9007-36-7 (Complement System Proteins)
0 (Immunoglobulin M)
تواريخ الأحداث: Date Created: 20240109 Date Completed: 20240111 Latest Revision: 20240614
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC10776791
DOI: 10.1038/s41467-023-44211-0
PMID: 38195739
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-44211-0