دورية أكاديمية
TGFβ macrophage reprogramming: a new dimension of macrophage plasticity.
| العنوان: | TGFβ macrophage reprogramming: a new dimension of macrophage plasticity. |
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| المؤلفون: | Oliver MA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN, 37232., Davis XD; Department of Anesthesiology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN, 37232., Bohannon JK; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN, 37232.; Department of Anesthesiology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN, 37232. |
| المصدر: | Journal of leukocyte biology [J Leukoc Biol] 2024 Feb 23; Vol. 115 (3), pp. 411-414. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: New York : Alan R. Liss, c1984- |
| مواضيع طبية MeSH: | Sepsis*/metabolism , COVID-19*/pathology, Mice ; Animals ; Humans ; Transforming Growth Factor beta ; Macrophages/metabolism ; Anti-Inflammatory Agents/metabolism ; Phosphofructokinases/metabolism ; Blood Coagulation Factors/metabolism ; Macrophage Activation |
| مستخلص: | The August 2023 article in Science Signaling, "TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis," challenges the traditional M1/M2 macrophage classification by investigating the impact of transforming growth factor β on macrophage metabolism and function. Despite its conventional anti-inflammatory role, transforming growth factor β-treated macrophages exhibit a distinct phenotype marked by heightened glycolysis, suppressed proinflammatory cytokines, and increased coagulation factor expression. The study identifies phosphofructokinase, liver type as a crucial glycolytic enzyme regulated by transforming growth factor β via the mTOR-c-MYC pathway. Epigenetic changes induced by transforming growth factor β, such as increased Smad3 activation and reduced proinflammatory transcription factor motif enrichment, contribute to the anti-inflammatory profile. The research extends its implications to sepsis, revealing the role of transforming growth factor β in exacerbating coagulation and reducing survival in mouse models. This effect involves upregulation of coagulation factor F13A1, dependent on phosphofructokinase, liver type activity and glycolysis in macrophages. Connections to COVID-19 pathology are drawn, as transforming growth factor β-treated macrophages and SARS-CoV-2 E protein-exposed cells display similar metabolic profiles. Bioinformatic analysis of COVID-19 patient data suggests correlations between myeloid expression of TGFβR1, PFKL, and F13A1 with disease severity. The study challenges the M1/M2 classification, emphasizing the complexity of macrophage responses influenced by transforming growth factor β, proposing transforming growth factor β as a potential therapeutic target for conditions like sepsis and COVID-19 where dysregulated coagulation is significant. Overall, the research provides valuable insights into transforming growth factor β-mediated immunometabolic regulation, paving the way for future investigations and potential therapeutic interventions. Competing Interests: Conflict of interest statement. None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: TGFβ; immunometabolism; inflammation; macrophage; sepsis |
| المشرفين على المادة: | 0 (Transforming Growth Factor beta) 0 (Anti-Inflammatory Agents) EC 2.7.1 - (Phosphofructokinases) 0 (Blood Coagulation Factors) |
| تواريخ الأحداث: | Date Created: 20240110 Date Completed: 20240226 Latest Revision: 20240305 |
| رمز التحديث: | 20240305 |
| DOI: | 10.1093/jleuko/qiae001 |
| PMID: | 38197509 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1938-3673 |
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| DOI: | 10.1093/jleuko/qiae001 |