دورية أكاديمية
Nicotinamide employs a starvation strategy against Porphyromonas gingivalis virulence by inhibiting the heme uptake system and gingipain activities.
| العنوان: | Nicotinamide employs a starvation strategy against Porphyromonas gingivalis virulence by inhibiting the heme uptake system and gingipain activities. |
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| المؤلفون: | Lei Z; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Ma Q; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Tu Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Qiu Y; Department of Endodontics, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou, China., Gong T; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Lin Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Zhou X; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China., Li Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China. |
| المصدر: | Molecular oral microbiology [Mol Oral Microbiol] 2024 Oct; Vol. 39 (5), pp. 321-333. Date of Electronic Publication: 2024 Jan 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: Denmark NLM ID: 101524770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1014 (Electronic) Linking ISSN: 20411006 NLM ISO Abbreviation: Mol Oral Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen : John Wiley & Sons |
| مواضيع طبية MeSH: | Porphyromonas gingivalis*/drug effects , Porphyromonas gingivalis*/pathogenicity , Porphyromonas gingivalis*/metabolism , Gingipain Cysteine Endopeptidases* , Niacinamide*/pharmacology , Heme*/metabolism , Adhesins, Bacterial*/metabolism , Adhesins, Bacterial*/drug effects , Periodontitis*/microbiology , Periodontitis*/prevention & control, Virulence/drug effects ; Animals ; Mice ; Hemolysis/drug effects ; Alveolar Bone Loss/prevention & control ; Alveolar Bone Loss/microbiology ; Disease Models, Animal ; Anti-Bacterial Agents/pharmacology ; Cysteine Endopeptidases/metabolism ; Hemagglutination/drug effects ; Bacteroidaceae Infections/microbiology ; Bacteroidaceae Infections/drug therapy ; Bacteroidaceae Infections/prevention & control ; Humans |
| مستخلص: | Periodontitis is a common oral bacterial infection characterized by inflammatory responses. Its high prevalence lowers the quality of life for individuals and increases the global economic and disease burden. As microorganisms in dental plaque are responsible for this oral disease, antibacterial drug treatments are effective strategies for preventing and treating periodontitis. In this study, we investigated the inhibitory effect of nicotinamide (NAM), a vitamin B (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 32170046 National Natural Science Foundation of China; 81991500 National Natural Science Foundation of China; 81991501 National Natural Science Foundation of China; 2022YFH0048 the Sichuan Science and Technology Program; ISTC202208 National Base for International Science and Technology Cooperation of Chengdu University |
| فهرسة مساهمة: | Keywords: Porphyromonas gingivalis; chlorhexidine; gingipain; heme; nicotinamide; periodontitis |
| المشرفين على المادة: | 0 (Gingipain Cysteine Endopeptidases) 25X51I8RD4 (Niacinamide) 42VZT0U6YR (Heme) 0 (Adhesins, Bacterial) 0 (Anti-Bacterial Agents) EC 3.4.22.- (Cysteine Endopeptidases) |
| تواريخ الأحداث: | Date Created: 20240110 Date Completed: 20240902 Latest Revision: 20240902 |
| رمز التحديث: | 20240902 |
| DOI: | 10.1111/omi.12448 |
| PMID: | 38197801 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2041-1014 |
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| DOI: | 10.1111/omi.12448 |