دورية أكاديمية
أعرض في EDS

Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: Altered expression of Sialyl Lewis X in experimental models of Parkinson's disease.
المؤلفون: Nunes MJ; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Carvalho AN; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Rosa AI; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Videira PA; Department of Life Sciences, UCIBIO, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. p.videira@fct.unl.pt.; CDG & Allies - Professionals and Patient Associations International Network (CDG & Allies - PPAIN), NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. p.videira@fct.unl.pt., Gama MJ; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Rodrigues E; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Castro-Caldas M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal. mcastrocaldas@ff.ulisboa.pt.; Department of Life Sciences, UCIBIO, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. mcastrocaldas@ff.ulisboa.pt.
المصدر: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2024 Mar; Vol. 102 (3), pp. 365-377. Date of Electronic Publication: 2024 Jan 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer International
Original Publication: Berlin : Springer, c1994-
مواضيع طبية MeSH: Parkinson Disease*/genetics , Parkinson Disease*/metabolism, Animals ; Mice ; Sialyl Lewis X Antigen ; Inflammation ; Brain/metabolism ; Models, Theoretical ; Disease Models, Animal ; Mice, Inbred C57BL
مستخلص: The mechanisms underlying neurodegeneration in Parkinson's disease (PD) are still not fully understood. Glycosylation is an important post-translational modification that affects protein function, cell-cell contacts and inflammation and can be modified in pathologic conditions. Although the involvement of aberrant glycosylation has been proposed for PD, the knowledge of the diversity of glycans and their role in PD is still minimal. Sialyl Lewis X (sLeX) is a sialylated and fucosylated tetrasaccharide with essential roles in cell-to-cell recognition processes. Pathological conditions and pro-inflammatory mediators can up-regulate sLeX expression on cell surfaces, which has important consequences in intracellular signalling and immune function. Here, we investigated the expression of this glycan using in vivo and in vitro models of PD. We show the activation of deleterious glycation-related pathways in mouse striatum upon treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin-based model of PD. Importantly, our results show that MPTP triggers the presentation of more proteins decorated with sLeX in mouse cortex and striatum in a time-dependent manner, as well as increased mRNA expression of its rate-limiting enzyme fucosyltransferase 7. sLeX is expressed in neurons, including dopaminergic neurons, and microglia. Although the underlying mechanism that drives increased sLeX epitopes, the nature of the protein scaffolds and their functional importance in PD remain unknown, our data suggest for the first time that sLeX in the brain may have a role in neuronal signalling and immunomodulation in pathological conditions. KEY MESSAGES: MPTP triggers the presentation of proteins decorated with sLeX in mouse brain. MPTP triggers the expression of sLeX rate-limiting enzyme FUT 7 in striatum. sLeX is expressed in neurons, including dopaminergic neurons, and microglia. sLeX in the brain may have a role in neuronal signalling and immunomodulation.
(© 2024. The Author(s).)
References: J Neurosci Res. 1994 Mar 1;37(4):466-74. (PMID: 7912739)
Front Genet. 2021 Sep 10;12:735348. (PMID: 34567084)
J Proteome Res. 2010 Mar 5;9(3):1496-509. (PMID: 20155936)
Cell Mol Life Sci. 2021 Feb;78(4):1445-1453. (PMID: 33052436)
Curr Protein Pept Sci. 2020;21(9):846-859. (PMID: 32368974)
EMBO Mol Med. 2021 Sep 7;13(9):e14332. (PMID: 34468083)
Adv Protein Chem Struct Biol. 2020;119:111-156. (PMID: 31997767)
Exp Neurol. 2017 Sep;295:77-87. (PMID: 28552716)
Front Neurosci. 2018 Jun 07;12:381. (PMID: 29930494)
Immunity. 2007 Apr;26(4):477-489. (PMID: 17442598)
FEBS Lett. 2016 May;590(10):1455-66. (PMID: 27086966)
Glycobiology. 2003 Jun;13(6):445-55. (PMID: 12626397)
FEBS J. 2006 Oct;273(19):4377-89. (PMID: 16956372)
Brain. 2012 Nov;135(Pt 11):3336-47. (PMID: 23169921)
Mol Neurobiol. 2018 Dec;55(12):9139-9155. (PMID: 29651747)
J Neurooncol. 2019 Jul;143(3):405-415. (PMID: 31104223)
Int J Oncol. 2019 Nov;55(5):1033-1048. (PMID: 31793656)
Neurobiol Aging. 2012 Oct;33(10):2478-90. (PMID: 22227007)
Mol Cell Probes. 2020 Dec;54:101671. (PMID: 33160071)
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5404-9. (PMID: 23493549)
Mol Neurobiol. 2019 Aug;56(8):5729-5739. (PMID: 30674035)
Bioinformatics. 2019 Oct 15;35(20):4140-4146. (PMID: 30903686)
J Proteome Res. 2021 Aug 6;20(8):3913-3924. (PMID: 34191522)
Mol Oncol. 2018 May;12(5):579-593. (PMID: 29215790)
J Parkinsons Dis. 2013;3(4):493-514. (PMID: 24275605)
J Biol Chem. 2018 May 11;293(19):7300-7314. (PMID: 29593094)
CNS Neurol Disord Drug Targets. 2014;13(9):1615-26. (PMID: 25106630)
Glycobiology. 2007 Jun;17(6):646-54. (PMID: 17341505)
Biochem J. 2012 Apr 1;443(1):213-22. (PMID: 22188542)
Front Neurosci. 2020 Apr 29;14:353. (PMID: 32410941)
Glycoconj J. 2020 Apr;37(2):277-291. (PMID: 32062824)
Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2171-2181. (PMID: 28583715)
Int Rev Neurobiol. 2018;141:347-363. (PMID: 30314603)
Redox Biol. 2021 Jun;42:101888. (PMID: 33602616)
Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2069-2080. (PMID: 29777742)
J Proteome Res. 2019 Oct 4;18(10):3770-3779. (PMID: 31437391)
Biochimie. 2008 Sep;90(9):1279-90. (PMID: 18395013)
J Mol Neurosci. 2009 Jun;38(2):114-27. (PMID: 18792812)
Biochem Biophys Res Commun. 2011 Jun 10;409(3):459-64. (PMID: 21596017)
Biol Chem. 2001 Feb;382(2):187-94. (PMID: 11308017)
Neuron. 2003 Sep 11;39(6):889-909. (PMID: 12971891)
Int J Mol Sci. 2018 Feb 15;19(2):. (PMID: 29462882)
J Inherit Metab Dis. 2021 Nov;44(6):1441-1452. (PMID: 34389986)
J Neurol Sci. 2012 Jun 15;317(1-2):1-5. (PMID: 22410257)
Neuroscience. 2014 Sep 5;275:113-24. (PMID: 24924144)
Cell Immunol. 2018 May;327:77-82. (PMID: 29478949)
Front Mol Neurosci. 2022 Nov 24;15:1078854. (PMID: 36504680)
Eur J Cell Biol. 2024 Mar;103(1):151377. (PMID: 38006841)
Front Neurosci. 2019 Jan 23;12:1035. (PMID: 30728759)
Mol Cell Neurosci. 2019 Apr;96:1-9. (PMID: 30771505)
معلومات مُعتمدة: PTDC/NEU-NMC/0248/2012 Fundação para a Ciência e a Tecnologia; SFRH/BPD/72891/2010 Fundação para a Ciência e a Tecnologia; UID/DTP/04138/2013 Fundação para a Ciência e a Tecnologia; UIDP/04378/2020 Fundação para a Ciência e a Tecnologia; UIDB/04378/2020 Fundação para a Ciência e a Tecnologia
فهرسة مساهمة: Keywords: Glycosylation; MPTP; Parkinson’s disease; Sialyl Lewis X
المشرفين على المادة: 0 (Sialyl Lewis X Antigen)
تواريخ الأحداث: Date Created: 20240110 Date Completed: 20240221 Latest Revision: 20240522
رمز التحديث: 20240522
مُعرف محوري في PubMed: PMC10879467
DOI: 10.1007/s00109-023-02415-3
PMID: 38197965
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1440
DOI:10.1007/s00109-023-02415-3