دورية أكاديمية
Clinical indications for carbon-ion radiotherapy in the UK: A critical review.
| العنوان: | Clinical indications for carbon-ion radiotherapy in the UK: A critical review. |
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| المؤلفون: | Light E; School of Health Sciences, University of Liverpool, United Kingdom., Bridge P; School of Health Sciences, University of Liverpool, United Kingdom. Electronic address: pete.bridge@liverpool.ac.uk. |
| المصدر: | Radiography (London, England : 1995) [Radiography (Lond)] 2024 Mar; Vol. 30 (2), pp. 425-430. Date of Electronic Publication: 2024 Jan 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9604102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2831 (Electronic) Linking ISSN: 10788174 NLM ISO Abbreviation: Radiography (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Amsterdam : Elsevier B.V. Original Publication: London ; Philadelphia : W.B. Saunders Co., c1995- |
| مواضيع طبية MeSH: | Chordoma*/radiotherapy , Carcinoma, Non-Small-Cell Lung* , Lung Neoplasms* , Chondrosarcoma* , Bone Neoplasms*, Male ; Humans ; Carbon ; United Kingdom |
| مستخلص: | Introduction: Carbon-ion radiotherapy (CIRT) has unique radiobiological properties that cause increased radiobiological effect and tumour control, especially with hypoxic tissues. This critical review aimed to evaluate clinical response to CIRT across all published tumour sites to establish if there is a clinical need for a CIRT centre in the UK. Methods: A critical review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searching was undertaken in November 2022 within the PubMed, Science Direct, SCOPUS and Web of Science databases using the term 'carbon ion radiotherapy' in the title, abstract or author keywords. Results: After critical appraisal, data was extracted from 78 primary study papers. Strong evidence supported use of CIRT for chondrosarcoma, chordoma, nasopharyngeal, non-small cell lung cancer (NSCLC), oral cavity, prostate, rectal and salivary gland tumours. Further research is needed to strengthen the evidence base for some other tumour types. Conclusion: The UK's incidence and mortality rates suggest a clinical need for CIRT for chondrosarcoma, chordoma, NSCLC, oral cavity, prostate, and rectal tumours. There is a need to improve survivorship amongst pancreatic, liver, and oesophageal cancer patients. Data published relating to CIRT for these tumours is promising but of lower quality and more research is needed in these areas. Implications for Practice: The clinical response to CIRT for certain tumours suggests the need for a carbon-ion centre in the UK. Demand for further research [phase III trials] has been identified, giving the UK opportunity to establish a research centre, with opportunity to treat, contributing to world-renowned research whilst improving patient outcomes. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Carbon; Critical review; Radiotherapy; Tumour control |
| المشرفين على المادة: | 7440-44-0 (Carbon) |
| تواريخ الأحداث: | Date Created: 20240110 Date Completed: 20240308 Latest Revision: 20240308 |
| رمز التحديث: | 20240308 |
| DOI: | 10.1016/j.radi.2023.12.014 |
| PMID: | 38199158 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2831 |
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| DOI: | 10.1016/j.radi.2023.12.014 |