Population genomics of post-glacial western Eurasia.

التفاصيل البيبلوغرافية
العنوان:	Population genomics of post-glacial western Eurasia.
المؤلفون:	Allentoft ME; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. morten.allentoft@curtin.edu.au.; Trace and Environmental DNA (TrEnD) Laboratory, School of Molecular and Life Sciences, Curtin University, Perth, Western Australia, Australia. morten.allentoft@curtin.edu.au., Sikora M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. martin.sikora@sund.ku.dk., Refoyo-Martínez A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Irving-Pease EK; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Fischer A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.; Sealand Archaeology, Kalundborg, Denmark., Barrie W; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Ingason A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark., Stenderup J; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Sjögren KG; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Pearson A; Department of Genetics, University of Cambridge, Cambridge, UK., Sousa da Mota B; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Schulz Paulsson B; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Halgren A; Department of Integrative Biology, University of California, Berkeley, CA, USA., Macleod R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Research Department of Genetics, Evolution and Environment, University College London, London, UK.; Department of Archaeology, University of Cambridge, Cambridge, UK., Jørkov MLS; Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark., Demeter F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Muséum National d'Histoire Naturelle, CNRS, Université de Paris, Musée de l'Homme, Paris, France., Sørensen L; The National Museum of Denmark, Copenhagen, Denmark., Nielsen PO; The National Museum of Denmark, Copenhagen, Denmark., Henriksen RA; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vimala T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., McColl H; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Margaryan A; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Centre for Evolutionary Hologenomics, University of Copenhagen, Copenhagen, Denmark., Ilardo M; Anthropology Department, University of Utah, Salt Lake City, UT, USA., Vaughn A; Center for Computational Biology, University of California, Berkeley, CA, USA., Fischer Mortensen M; The National Museum of Denmark, Copenhagen, Denmark., Nielsen AB; Department of Geology, Lund University, Lund, Sweden., Ulfeldt Hede M; Tårnby Gymnasium og HF, Kastrup, Denmark., Johannsen NN; Department of Archaeology and Heritage Studies, Aarhus University, Aarhus, Denmark., Rasmussen P; The National Museum of Denmark, Copenhagen, Denmark., Vinner L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Renaud G; Department of Health Technology, Section of Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark., Stern A; Center for Computational Biology, University of California, Berkeley, CA, USA., Jensen TZT; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Scorrano G; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Schroeder H; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Lysdahl P; Vendsyssel Historiske Museum, Hjørring, Denmark., Ramsøe AD; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Skorobogatov A; Terra Ltd., Voronezh, Russian Federation., Schork AJ; Department of Genetics, University of Cambridge, Cambridge, UK.; Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA., Rosengren A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Genetics, University of Cambridge, Cambridge, UK., Ruter A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Outram A; Department of Archaeology, University of Exeter, Exeter, UK., Timoshenko AA; Institute of Archeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Buzhilova A; Department of Anthropology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation., Coppa A; Department of Environmental Biology, Sapienza University of Rome, Rome, Italy., Zubova A; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Saint Petersburg, Russian Federation., Silva AM; CIAS, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.; UNIARQ, University of Lisbon, Lisbon, Portugal., Hansen AJ; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Gromov A; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Saint Petersburg, Russian Federation., Logvin A; Kostanay Regional University A. Baitursynov, Kostanay, Kazakhstan., Gotfredsen AB; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Henning Nielsen B; Vesthimmerlands Museum, Aars, Denmark., González-Rabanal B; Grupo EvoAdapta, Departamento de Ciencias Históricas, Universidad de Cantabria, Santander, Spain., Lalueza-Fox C; Institute of Evolutionary Biology, CSIC-Universitat Pompeu Fabra, Barcelona, Spain.; Natural Sciences Museum of Barcelona (MCNB), Barcelona, Spain., McKenzie CJ; Department of Archaeology, University of Exeter, Exeter, UK., Gaunitz C; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Blasco C; Departamento de Prehistoria y Arqueología, Universidad Autónoma de Madrid, Madrid, Spain., Liesau C; Departamento de Prehistoria y Arqueología, Universidad Autónoma de Madrid, Madrid, Spain., Martinez-Labarga C; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Pozdnyakov DV; Institute of Archeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Cuenca-Solana D; Instituto Internacional de Investigaciones Prehistóricas de Cantabria, Universidad de Cantabria, Banco Santander, Gobierno de Cantabria, Santander, Spain.; Centre de Recherche en Archéologie, Archeosciences, Histoire (CReAAH), UMR-6869 CNRS, Rennes, France., Lordkipanidze DO; Georgian National Museum, Tbilisi, Georgia.; Tbilisi State University, Tbilisi, Georgia., En'shin D; IPND, Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russian Federation., Salazar-García DC; Departament de Prehistòria, Arqueologia i Història Antiga, Universitat de València, València, Spain.; Department of Geological Sciences, University of Cape Town, Cape Town, South Africa., Price TD; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.; Laboratory for Archaeological Chemistry, Department of Anthropology, University of Wisconsin-Madison, Madison, WI, USA., Borić D; Department of Environmental Biology, Sapienza University of Rome, Rome, Italy.; Department of Anthropology, New York University, New York, NY, USA., Kostyleva E; Institute of Humanities, Ivanovo State University, Ivanovo, Russian Federation., Veselovskaya EV; Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, Russian Federation., Usmanova ER; Saryarka Archaeological Institute, Buketov Karaganda University, Karaganda, Kazakhstan.; South Ural State University, Chelyabinsk, Russia.; A. Kh. Khalikov Institute of Archeology of the Academy of Sciences of the Republic of Tatarstan, Kazan, Russia.; Margulan Institute of Archaeology, Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan, Almaty, Kazakhstan., Cappellini E; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Brinch Petersen E; The Saxo Institute, University of Copenhagen, Copenhagen, Denmark., Kannegaard E; Museum Østjylland, Randers, Denmark., Radina F; Soprintendenza Archeologia Belle Arti e Paesaggio per la Città Metropolitana di Bari, Bari, Italy., Eylem Yediay F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Duday H; UMR 5199 PACEA, CNRS, Université de Bordeaux, Pessac, France., Gutiérrez-Zugasti I; Instituto Internacional de Investigaciones Prehistóricas de Cantabria, Universidad de Cantabria, Banco Santander, Gobierno de Cantabria, Santander, Spain., Merts I; A.Kh. Margulan Institute of Archaeology, Almaty, Kazakhstan., Potekhina I; Institute of Archaeology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.; National University of Kyiv-Mohyla Academy, Kyiv, Ukraine., Shevnina I; Kostanay Regional University A. Baitursynov, Kostanay, Kazakhstan., Altinkaya I; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Guilaine J; Collège de France, Paris, France., Hansen J; Svendborg Museum, Svendborg, Denmark., Aura Tortosa JE; Departament de Prehistòria, Arqueologia i Història Antiga, Universitat de València, València, Spain., Zilhão J; UNIARQ, University of Lisbon, Lisbon, Portugal.; ICREA, University of Barcelona, Barcelona, Spain., Vega J; ARGEA Consultores SL, Madrid, Spain., Buck Pedersen K; Museum Sydøstdanmark, Vordingborg, Denmark., Tunia K; Institute of Archaeology and Ethnology, Polish Academy of Sciences, Kraków, Poland., Zhao L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Mylnikova LN; Institute of Archeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Larsson L; Department of Archaeology and Ancient History, Lund University, Lund, Sweden., Metz L; Aix-Marseille Université, CNRS, Min. Culture, UMR 7269, LAMPEA, Maison Méditerranéenne des Sciences de l'Homme, Aix-en-Provence, France., Yepiskoposyan L; Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.; Russian-Armenian University, Yerevan, Armenia., Pedersen L; HistorieUdvikler, Kalundborg, Denmark., Sarti L; Department of History and Cultural Heritage, University of Siena, Siena, Italy., Orlando L; Centre d'Anthropobiologie et de Génomique de Toulouse, CNRS UMR 5500, Université Paul Sabatier, Toulouse, France., Slimak L; Centre d'Anthropobiologie et de Génomique de Toulouse, CNRS UMR 5500, Université Paul Sabatier, Toulouse, France., Klassen L; Museum Østjylland, Randers, Denmark., Blank M; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., González-Morales M; Instituto Internacional de Investigaciones Prehistóricas de Cantabria, Universidad de Cantabria, Banco Santander, Gobierno de Cantabria, Santander, Spain., Silvestrini M; Soprintendenza per i Beni Archeologici delle Marche, Ancona, Italy., Vretemark M; Västergötlands Museum, Skara, Sweden., Nesterova MS; Institute of Archeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Rykun M; Cabinet of Anthropology, Tomsk State University, Tomsk, Russian Federation., Rolfo MF; Department of History, Humanities and Society, University of Rome Tor Vergata, Rome, Italy., Szmyt M; Faculty of Archaeology, Adam Mickiewicz University in Poznań, Poznań, Poland., Przybyła M; Institute of Archaeology, Jagiellonian University, Kraków, Poland., Calattini M; Department of History and Cultural Heritage, University of Siena, Siena, Italy., Sablin M; Zoological Institute of Russian Academy of Sciences, Saint Petersburg, Russian Federation., Dobisíková M; Department of Anthropology, Czech National Museum, Prague, Czech Republic., Meldgaard M; Department of Health and Nature, University of Greenland, Nuuk, Greenland., Johansen M; The Viking Ship Museum, Roskilde, Denmark., Berezina N; Department of Anthropology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation., Card N; Archaeology Institute, University of Highlands and Islands, Orkney, UK., Saveliev NA; Scientific Research Center 'Baikal region', Irkutsk State University, Irkutsk, Russian Federation., Poshekhonova O; IPND, Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russian Federation., Rickards O; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Lozovskaya OV; Laboratory for Experimental Traceology, Institute for the History of Material Culture of the Russian Academy of Sciences, Saint Petersburg, Russian Federation., Gábor O; Janus Pannonius Museum, Pécs, Hungary., Uldum OC; The Viking Ship Museum, Roskilde, Denmark.; Langelands Museum, Rudkøbing, Denmark., Aurino P; Soprintendenza Archeologia, Belle Arti e Paesaggio per la provincia di Cosenza, Cosenza, Italy., Kosintsev P; Paleoecology Laboratory, Institute of Plant and Animal Ecology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation.; Department of History of the Institute of Humanities, Ural Federal University, Ekaterinburg, Russian Federation., Courtaud P; UMR 5199 PACEA, CNRS, Université de Bordeaux, Pessac, France., Ríos P; Departamento de Prehistoria y Arqueología, Universidad Autónoma de Madrid, Madrid, Spain., Mortensen P; Centre for the Study of Early Agricultural Societies, Department of Cross-Cultural and Regional Studies, University of Copenhagen, Copenhagen, Denmark., Lotz P; Museum Nordsjælland, Hillerød, Denmark.; Museum Vestsjælland, Holbæk, Denmark., Persson P; Museum of Cultural History, University of Oslo, Oslo, Norway., Bangsgaard P; ArchaeoScience, Globe Institute, University of Copenhagen, Copenhagen, Denmark., de Barros Damgaard P; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vang Petersen P; The National Museum of Denmark, Copenhagen, Denmark., Martinez PP; Department of History, University of Santiago de Compostela, Santiago de Compostela, Spain., Włodarczak P; Institute of Archaeology and Ethnology, Polish Academy of Sciences, Kraków, Poland., Smolyaninov RV; Lipetsk Regional Scientific Public Organisation 'Archaeological Research', Lipetsk, Russian Federation., Maring R; Department of Health Technology, Section of Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark.; Museum Østjylland, Randers, Denmark., Menduiña R; ARGEA Consultores SL, Madrid, Spain., Badalyan R; Institute of Archaeology and Ethnography, National Academy of Sciences, Yerevan, Armenia., Iversen R; The Saxo Institute, University of Copenhagen, Copenhagen, Denmark., Turin R; Terra Ltd., Voronezh, Russian Federation., Vasilyev S; Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, Russian Federation.; Center for Egyptological Studies, Russian Academy of Sciences, Moscow, Russian Federation., Wåhlin S; Vendsyssel Historiske Museum, Hjørring, Denmark., Borutskaya S; Department of Anthropology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation., Skochina S; IPND, Tyumen Scientific Centre, Siberian Branch of the Russian Academy of Sciences, Tyumen, Russian Federation., Sørensen SA; Museum Nordsjælland, Hillerød, Denmark., Andersen SH; Moesgaard Museum, Højbjerg, Denmark., Jørgensen T; Museum Nordsjælland, Hillerød, Denmark., Serikov YB; Nizhny Tagil State Socio-Pedagogical Institute, Nizhny Tagil, Russia., Molodin VI; Institute of Archeology and Ethnography, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation., Smrcka V; Institute for History of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic., Merts V; Centre for Archaeological Research, Toraighyrov University, Pavlodar, Kazakhstan., Appadurai V; Department of Genetics, University of Cambridge, Cambridge, UK., Moiseyev V; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Saint Petersburg, Russian Federation., Magnusson Y; Malmö Museer, Malmö, Sweden., Kjær KH; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Lynnerup N; Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark., Lawson DJ; Institute of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK., Sudmant PH; Department of Integrative Biology, University of California, Berkeley, CA, USA.; Center for Computational Biology, University of California, Berkeley, CA, USA., Rasmussen S; Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Korneliussen TS; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Durbin R; Department of Genetics, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Nielsen R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Integrative Biology, University of California, Berkeley, CA, USA., Delaneau O; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Werge T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Genetics, University of Cambridge, Cambridge, UK.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Racimo F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Kristiansen K; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Willerslev E; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. ew482@cam.ac.uk.; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK. ew482@cam.ac.uk.; MARUM Center for Marine Environmental Sciences and Faculty of Geosciences, University of Bremen, Bremen, Germany. ew482@cam.ac.uk.
المصدر:	Nature [Nature] 2024 Jan; Vol. 625 (7994), pp. 301-311. Date of Electronic Publication: 2024 Jan 10.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة:	Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH:	Genetics, Population* , Genome, Human* , Human Migration/history , Metagenomics, Humans ; Agriculture/history ; Asia, Western ; Black Sea ; Diploidy ; Europe/ethnology ; Genotype ; History, Ancient ; Hunting/history ; Ice Cover
مستخلص:	Western Eurasia witnessed several large-scale human migrations during the Holocene ^1-5 . Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations. (© 2024. The Author(s).)
التعليقات:	Erratum in: Nature. 2024 Feb;626(7997):E3. (PMID: 38238538)
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معلومات مُعتمدة:	207492/Z/17/Z United Kingdom WT_ Wellcome Trust; U19 AG023122 United States AG NIA NIH HHS; R35 GM142916 United States GM NIGMS NIH HHS; UH2 AG064706 United States AG NIA NIH HHS; U24 AG051129 United States AG NIA NIH HHS; R01 GM138634 United States GM NIGMS NIH HHS; United Kingdom WT_ Wellcome Trust
تواريخ الأحداث:	Date Created: 20240110 Date Completed: 20240112 Latest Revision: 20240313
رمز التحديث:	20240313
مُعرف محوري في PubMed:	PMC10781627
DOI:	10.1038/s41586-023-06865-0
PMID:	38200295
قاعدة البيانات:	MEDLINE

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DOI:	10.1038/s41586-023-06865-0