دورية أكاديمية
Phytochemical composition of aerial parts and roots of Pfaffia glomerata (Spreng.) Pedersen and anticholinesterase, antioxidant, and antiglycation activities.
| العنوان: | Phytochemical composition of aerial parts and roots of Pfaffia glomerata (Spreng.) Pedersen and anticholinesterase, antioxidant, and antiglycation activities. |
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| المؤلفون: | Franco RR; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil.; Departamento de Medicina, Instituto de Biotecnologia, Universidade Federal de Catalão, Catalão, GO, 75706-881, Brazil., Franco RM; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Justino AB; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Borges ALS; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Bittar VP; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Saito N; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Saraiva AL; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Júnior NN; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil., Otoni WC; Departamento de Biologia Vegetal, Laboratório de Cultura de Tecidos/BIOAGRO, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil., Espindola FS; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Rua Acre, S/N, Bloco 2E/237, Uberlândia, MG, CEP 38405-319, 38408-100, Brazil. foued@ufu.br. |
| المصدر: | Protoplasma [Protoplasma] 2024 Jul; Vol. 261 (4), pp. 609-624. Date of Electronic Publication: 2024 Jan 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Austria NLM ID: 9806853 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-6102 (Electronic) Linking ISSN: 0033183X NLM ISO Abbreviation: Protoplasma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1998->: Wien ; New York : Springer Original Publication: Leipzig : Verlag von Gebrüder Borntraeger, 1927- |
| مواضيع طبية MeSH: | Antioxidants*/pharmacology , Antioxidants*/chemistry , Plant Roots*/chemistry , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Plant Components, Aerial*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Humans |
| مستخلص: | The Pfaffia glomerata, a plant popularly called Brazilian ginseng, is widely used in Brazil for the treatment of various pathologies, including those associated with the Central Nervous System. 20-hydroxyecdysone (20E), a phytosteroid present in this plant, can promote adaptogenic effects in the organism, providing greater body resistance to stressors. This study aimed to evaluate the phytochemical composition and the anticholinesterase, antioxidant, and antiglycation effects of extracts and fractions of aerial parts and roots of P. glomerata, also analyzing their possible cytotoxic effects. The fractions were obtained by partitioning methanol extracts from the aerial part and roots of P. glomerata with hexane, dichloromethane, ethyl acetate, n-butanol, and water. The samples were initially tested in anticholinesterase, antioxidant, and antiglycation assays, and the most promising samples were submitted for cytotoxicity and chromatographic analyses. Mass spectrometry and chromatography methods revealed that 20E was the main compound in the dichloromethane fractions, there being 35% more 20E in the aerial part (APD) than in the roots (RD). Added to the higher concentration of 20E, the APD fraction also presented more promising results than the RD fraction in anticholinesterase and antioxidant analyses, indicating that their effects may be related to the concentration of 20E. These same fractions showed no hemolytic effects but were cytotoxic in high concentrations. These new findings contribute to scientific information about P. glomerata and open more perspectives for the understanding of its therapeutic properties, allowing the association of biological activity with the presence of 20E. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Alzheimer; Brazilian ginseng; Natural products; Oxidative status; β-ecdysone |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Cholinesterase Inhibitors) 0 (Phytochemicals) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240110 Date Completed: 20240624 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| DOI: | 10.1007/s00709-023-01916-9 |
| PMID: | 38200344 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1615-6102 |
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| DOI: | 10.1007/s00709-023-01916-9 |