دورية أكاديمية
أعرض في EDS

Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF-κB signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF-κB signaling pathway.
المؤلفون: Chu L; Clinical Laboratory, The People's Hospital of Danyang & Affiliated Danyang Hospital of Nantong University, Danyang, China., Zhang S; Clinical Laboratory, The People's Hospital of Danyang & Affiliated Danyang Hospital of Nantong University, Danyang, China.; State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China., Wu W; Clinical Laboratory, The People's Hospital of Danyang & Affiliated Danyang Hospital of Nantong University, Danyang, China., Gong Y; State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China., Chen Z; Clinical Laboratory, The People's Hospital of Danyang & Affiliated Danyang Hospital of Nantong University, Danyang, China., Wen Y; State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China., Wang Y; State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China., Wang L; State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, China.
المصدر: Environmental toxicology [Environ Toxicol] 2024 May; Vol. 39 (5), pp. 2572-2582. Date of Electronic Publication: 2024 Jan 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 100885357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-7278 (Electronic) Linking ISSN: 15204081 NLM ISO Abbreviation: Environ Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : John Wiley & Sons, c1999-
مواضيع طبية MeSH: Colitis, Ulcerative*/chemically induced , Colitis, Ulcerative*/drug therapy , Grape Seed Extract* , Proanthocyanidins*, Animals ; Humans ; Mice ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/toxicity ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Quality of Life ; Signal Transduction
مستخلص: Ulcerative colitis (UC) is a complex inflammatory disease of colorectum that induces abnormal immune responses and severely affects the quality of life of the patients. Grape seed proanthocyanidin extract (GSPE) exerts anti-inflammatory and antioxidant functions in many inflammatory diseases. The objective of this study was to investigate the potential therapeutic effects and underlying mechanisms of GSPE in UC using a dextran sodium sulfate (DSS)-induced mouse UC model and a lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage model. In this study, we found that the GSPE markedly prevented DSS-induced weight loss and colon length shortening in UC mice. Further investigations showed that GSPE significantly attenuated the expression of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β, and elevated the expression of anti-inflammatory cytokine IL-10 in the colon tissues and serum of DSS-induced colitis mice by suppressing NF-κB signaling pathway. Furthermore, LPS-induced inflammation in RAW264.7 cells was also reversed by GSPE. Taken together, our results confirm that GSPE can ameliorate inflammatory response in experimental colitis via inhibiting NF-κB signaling pathway. This study advances the research progress on a potentially effective therapeutic strategy for inflammatory bowel diseases.
(© 2024 The Authors. Environmental Toxicology published by Wiley Periodicals LLC.)
References: Du L, Ha C. Epidemiology and pathogenesis of ulcerative colitis. Gastroenterol Clin North Am. 2020;49(4):643‐654. doi:10.1016/j.gtc.2020.07.005.
Eisenstein M. Ulcerative colitis: towards remission. Nature. 2018;563(7730):S33. doi:10.1038/d41586‐018‐07276‐2.
Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012;380(9853):1606‐1619. doi:10.1016/S0140‐6736(12)60150‐0.
Ungaro R, Mehandru S, Allen PB, Peyrin‐Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756‐1770. doi:10.1016/S0140‐6736(16)32126‐2.
Segal JP, LeBlanc JF, Hart AL. Ulcerative colitis: an update. Clin Med (Lond). 2021;21(2):135‐139. doi:10.7861/clinmed.2021‐0080.
Burri E, Maillard MH, Schoepfer AM, et al. Treatment algorithm for mild and moderate‐to‐severe ulcerative colitis: an update. Digestion. 2020;101(Suppl 1):2‐15. doi:10.1159/000504092.
Adams SM, Close ED, Shreenath AP. Ulcerative colitis: rapid evidence review. Am Fam Physician. 2022;105(4):406‐411.
Nascimento R d P d, Machado AP d F, Galvez J, Cinthia BBC, Maróstica Junior MR. Ulcerative colitis: gut microbiota, immunopathogenesis and application of natural products in animal models. Life Sci. 2020;258:118129. doi:10.1016/j.lfs.2020.118129.
Rauf A, Imran M, Abu‐Izneid T, et al. Proanthocyanidins: a comprehensive review. Biomed Pharmacother. 2019;116:108999. doi:10.1016/j.biopha.2019.108999.
Zeng YX, Wang S, Wei L, Cui YY, Chen YH. Proanthocyanidins: components, pharmacokinetics and biomedical properties. Am J Chin Med. 2020;48(4):813‐869. doi:10.1142/S0192415X2050041X.
Mancini M, Cerny MEV, Cardoso NS, Verissimo G, Maluf SW. Grape seed components as protectors of inflammation, DNA damage, and cancer. Curr Nutr Rep. 2023;12(1):141‐150. doi:10.1007/s13668‐023‐00460‐5.
Ruan Y, Jin Q, Zeng J, et al. Grape seed Proanthocyanidin extract ameliorates cardiac Remodelling after myocardial infarction through PI3K/AKT pathway in mice. Front Pharmacol. 2020;11:585984. doi:10.3389/fphar.2020.585984.
Wang S, Liu Z, Wang Y, et al. Grape seed extract proanthocyanidin antagonizes aristolochic acid I‐induced liver injury in rats by activating PI3K‐AKT pathway. Toxicol Mech Methods. 2023;33(2):131‐140. doi:10.1080/15376516.2022.2103479.
Hu Y, Wei M, Niu Q, et al. Grape seed proanthocyanidin extract alleviates arsenic‐induced lung damage through NF‐κB signaling. Exp Biol Med. 2019;244(3):213‐226. doi:10.1177/1535370219829881.
Liu M, Yun P, Hu Y, Yang J, Khadka RB, Peng X. Effects of grape seed Proanthocyanidin extract on obesity. Obes Facts. 2020;13(2):279‐291. doi:10.1159/000502235.
Sun Q, Jia N, Li X, Yang J, Chen G. Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK‐3β‐dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer's disease. Aging. 2019;11(12):4107‐4124. doi:10.18632/aging.102041.
Tu X, Wang M, Liu Y, et al. Pretreatment of grape seed Proanthocyanidin extract exerts neuroprotective effect in murine model of neonatal hypoxic‐ischemic brain injury by its antiapoptotic property. Cell Mol Neurobiol. 2019;39(7):953‐961. doi:10.1007/s10571‐019‐00691‐7.
Liu G, Shi A, Wang N, et al. Polyphenolic Proanthocyanidin‐B2 suppresses proliferation of liver cancer cells and hepatocellular carcinogenesis through directly binding and inhibiting AKT activity. Redox Biol. 2020;37:101701. doi:10.1016/j.redox.2020.101701.
Wang R, Wang L, Luo Y, et al. Maggot protein ameliorates dextran sulphate sodium‐induced ulcerative colitis in mice. Biosci Rep. 2018;38(6):BSR20181799. doi:10.1042/BSR20181799.
Wang R, Wang D, Wang H, et al. Therapeutic targeting of Nrf2 signaling by maggot extracts ameliorates inflammation‐associated intestinal fibrosis in chronic DSS‐induced colitis. Front Immunol. 2021;12:12. doi:10.3389/fimmu.2021.670159.
Perše M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol. 2012;2012:1‐13. doi:10.1155/2012/718617.
Hu L, Jin L, Xia D, et al. Nitrate ameliorates dextran sodium sulfate‐induced colitis by regulating the homeostasis of the intestinal microbiota. Free Radic Biol Med. 2020;152:609‐621. doi:10.1016/j.freeradbiomed.2019.12.002.
Sayer B, Lu J, Green C, Söderholm JD, Akhtar M, McKay DM. Dextran sodium sulphate‐induced colitis perturbs muscarinic cholinergic control of colonic epithelial ion transport. Br J Pharmacol. 2002;135(7):1794‐1800. doi:10.1038/sj.bjp.0704633.
Zhang Y, Feng X, Lin H, et al. Tieguanyin extracts ameliorated DSS‐induced mouse colitis by suppressing inflammation and regulating intestinal microbiota. Food Funct. 2022;13(24):13040‐13051. doi:10.1039/D2FO02781J.
Jialing L, Yangyang G, Jing Z, et al. Changes in serum inflammatory cytokine levels and intestinal flora in a self‐healing dextran sodium sulfate‐induced ulcerative colitis murine model. Life Sci. 2020;263:118587. doi:10.1016/j.lfs.2020.118587.
Barnabei L, Laplantine E, Mbongo W, Rieux‐Laucat F, Weil R. NF‐κB: At the Borders of autoimmunity and inflammation. Front Immunol. 2021;12:716469. doi:10.3389/fimmu.2021.716469.
Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L. Punicalagin prevents inflammation in LPS‐induced RAW264.7 macrophages by inhibiting FoxO3a/autophagy signaling pathway. Nutrients. 2019;11(11):2794. doi:10.3390/nu11112794.
Wang R, Luo Y, Lu Y, et al. Maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of Nrf2. Oxid Med Cell Longev. 2019;2019:4703253. doi:10.1155/2019/4703253.
Porter RJ, Kalla R, Ho GT. Ulcerative colitis: Recent advances in the understanding of disease pathogenesis. F1000Research. 2020;9(F1000 Faculty Rev):294. doi:10.12688/f1000research.20805.1.
Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021;18(1):56‐66. doi:10.1038/s41575‐020‐00360‐x.
Windsor JW, Kaplan GG. Evolving epidemiology of IBD. Curr Gastroenterol Rep. 2019;21(8):40. doi:10.1007/s11894‐019‐0705‐6.
Chassaing B, Aitken JD, Malleshappa M, Vijay‐Kumar M. Dextran sulfate sodium (DSS)‐induced colitis in mice. Curr Protoc Immunol. 2014;104:15.25.1‐15.25.14. doi:10.1002/0471142735.im1525s104.
Chang X, Tian M, Zhang Q, et al. Grape seed proanthocyanidin extract ameliorates cisplatin‐induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats. J Food Biochem. 2021;21:e13825. doi:10.1111/jfbc.13825.
Chen S, Zhu Y, Liu Z, et al. Grape seed Proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway. PLoS One. 2015;10(5):e0126457. doi:10.1371/journal.pone.0126457.
Li SG, Ding YS, Niu Q, et al. Grape seed Proanthocyanidin extract alleviates arsenic‐induced oxidative reproductive toxicity in male mice. Biomed Environ Sci. 2015;28(4):272‐280. doi:10.3967/bes2015.038.
Song Y, Yu H, Sun Q, et al. Grape seed proanthocyanidin extract targets p66Shc to regulate mitochondrial biogenesis and dynamics in diabetic kidney disease. Front Pharmacol. 2022;13:13. doi:10.3389/fphar.2022.1035755.
Yang D, Li S, Gao L, et al. Dietary grape seed procyanidin extract protects against lead‐induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation. J Nutr Biochem. 2018;62:43‐49. doi:10.1016/j.jnutbio.2018.07.013.
Qi Y, Chen S, Lu Y, et al. Grape seed proanthocyanidin extract ameliorates ionizing radiation‐induced hematopoietic stem progenitor cell injury by regulating Foxo1 in mice. Free Radic Biol Med. 2021;174:144‐156. doi:10.1016/j.freeradbiomed.2021.08.010.
Mo J, Ni J, Zhang M, et al. Mulberry anthocyanins ameliorate DSS‐induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota. Antioxidants. 2022;11(9):1674. doi:10.3390/antiox11091674.
Panpetch W, Hiengrach P, Nilgate S, et al. Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut‐enhanced systemic inflammation and gut‐dysbiosis but attenuated by Lactobacillus rhamnosus L34. Gut Microbes. 2020;11(3):465‐480. doi:10.1080/19490976.2019.1662712.
Tatiya‐Aphiradee N, Chatuphonprasert W, Jarukamjorn K. Immune response and inflammatory pathway of ulcerative colitis. J Basic Clin Physiol Pharmacol. 2018;30(1):1‐10. doi:10.1515/jbcpp‐2018‐0036.
Ouyang W, O'Garra A. IL‐10 family cytokines IL‐10 and IL‐22: from basic science to clinical translation. Immunity. 2019;50(4):871‐891. doi:10.1016/j.immuni.2019.03.020.
Wei HX, Wang B, Li B. IL‐10 and IL‐22 in mucosal immunity: driving protection and pathology. Front Immunol. 2020;11:1315. doi:10.3389/fimmu.2020.01315.
Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor κB in inflammatory bowel disease. Gut. 1998;42(4):477‐484.
Hoesel B, Schmid JA. The complexity of NF‐κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. doi:10.1186/1476‐4598‐12‐86.
Adams SM, Bornemann PH. Ulcerative colitis. Am Fam Physician. 2013;87(10):699‐705.
Li W, Zhao T, Wu D, et al. Colorectal cancer in ulcerative colitis: mechanisms, Surveillance and Chemoprevention. Curr Oncol. 2022;29(9):6091‐6114. doi:10.3390/curroncol29090479.
Bopanna S, Ananthakrishnan AN, Kedia S, Yajnik V, Ahuja V. Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta‐analysis. Lancet Gastroenterol Hepatol. 2017;2(4):269‐276. doi:10.1016/S2468‐1253(17)30004‐3.
Yashiro M. Ulcerative colitis‐associated colorectal cancer. World J Gastroenterol. 2014;20(44):16389‐16397. doi:10.3748/wjg.v20.i44.16389.
Yang N, Gao J, Hou R, Xu X, Yang N, Huang S. Grape seed Proanthocyanidins inhibit migration and invasion of bladder cancer cells by reversing EMT through suppression of TGF‐β signaling pathway. Oxid Med Cell Longev. 2021;2021:5564312. doi:10.1155/2021/5564312.
Guo F, Hu Y, Niu Q, et al. Grape seed Proanthocyanidin extract inhibits human esophageal squamous cancerous cell line ECA109 via the NF‐κB signaling pathway. Mediators Inflamm. 2018;2018:3403972. doi:10.1155/2018/3403972.
Katiyar SK. Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol Nutr Food Res. 2008;52(Suppl 1):S71‐S76. doi:10.1002/mnfr.200700198.
Mao JT, Xue B, Smoake J, et al. MicroRNA‐19a/b mediates grape seed procyanidin extract‐induced anti‐neoplastic effects against lung cancer. J Nutr Biochem. 2016;34:118‐125. doi:10.1016/j.jnutbio.2016.05.003.
Habib HM, El‐Fakharany EM, Kheadr E, Ibrahim WH. Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities. Sci Rep. 2022;12(1):12393. doi:10.1038/s41598‐022‐16608‐2.
Liu J, Zhang WY, Kong ZH, Ding DG. Induction of cell cycle arrest and apoptosis by grape seed procyanidin extract in human bladder cancer BIU87 cells. Eur Rev Med Pharmacol Sci. 2016;20(15):3282‐3291.
معلومات مُعتمدة: 81771539 National Natural Science Foundation of China; 31700444 National Natural Science Foundation of China; 81971346 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: NF‐κB signaling pathway; RAW264.7; grape seed proanthocyanidin extract; inflammation; ulcerative colitis
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Cytokines)
0 (Grape Seed Extract)
0 (Grape Seed Proanthocyanidins)
0 (Lipopolysaccharides)
0 (NF-kappa B)
0 (Proanthocyanidins)
تواريخ الأحداث: Date Created: 20240111 Date Completed: 20240417 Latest Revision: 20240506
رمز التحديث: 20240506
DOI: 10.1002/tox.24129
PMID: 38205677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-7278
DOI:10.1002/tox.24129