دورية أكاديمية
Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population.
العنوان: | Mass spectrometry-detected MGUS is associated with obesity and other novel modifiable risk factors in a high-risk population. |
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المؤلفون: | Lee DJ; Department of Medicine, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., El-Khoury H; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Tramontano AC; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA., Alberge JB; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Perry J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Davis MI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Horowitz E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Redd R; Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA., Sakrikar D; The Binding Site Inc, Rochester, MN., Barnidge D; The Binding Site Inc, Rochester, MN., Perkins MC; The Binding Site Group Ltd, Birmingham, United Kingdom., Harding S; The Binding Site Group Ltd, Birmingham, United Kingdom., Mucci L; Harvard T.H. Chan School of Public Health, Boston, MA., Rebbeck TR; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA.; Harvard T.H. Chan School of Public Health, Boston, MA., Ghobrial IM; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA., Marinac CR; Harvard Medical School, Boston, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA. |
المصدر: | Blood advances [Blood Adv] 2024 Apr 09; Vol. 8 (7), pp. 1737-1746. |
نوع المنشور: | Clinical Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Society of Hematology, [2016]- |
مواضيع طبية MeSH: | Monoclonal Gammopathy of Undetermined Significance*/diagnosis , Monoclonal Gammopathy of Undetermined Significance*/epidemiology , Monoclonal Gammopathy of Undetermined Significance*/complications , Multiple Myeloma*/diagnosis , Multiple Myeloma*/epidemiology , Multiple Myeloma*/etiology, Humans ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Risk Factors |
مستخلص: | Abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition of multiple myeloma with few known risk factors. The emergence of mass spectrometry (MS) for the detection of MGUS has provided new opportunities to evaluate its risk factors. In total, 2628 individuals at elevated risk for multiple myeloma were enrolled in a screening study and completed an exposure survey (PROMISE trial). Participant samples were screened by MS, and monoclonal proteins (M-proteins) with concentrations of ≥0.2 g/L were categorized as MS-MGUS. Multivariable logistic models evaluated associations between exposures and MS outcomes. Compared with normal weight (body mass index [BMI] of 18.5 to <25 kg/m2), obesity (BMI of ≥30 kg/m2) was associated with MS-MGUS, adjusting for age, sex, Black race, education, and income (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.21-2.47; P = .003). High physical activity (≥73.5 metabolic equivalent of task (MET)-hours per week vs <10.5 MET-hours per week) had a decreased likelihood of MS-MGUS (OR, 0.45, 95% CI, 0.24-0.80; P = .009), whereas heavy smoking and short sleep had increased likelihood of MS-MGUS (>30 pack-years vs never smoker: OR, 2.19; 95% CI, 1.24-3.74; P = .005, and sleep <6 vs ≥6 hours per day: OR, 2.11; 95% CI, 1.26-3.42; P = .003). In the analysis of all MS-detected monoclonal gammopathies, which are inclusive of M-proteins with concentrations of <0.2 g/L, elevated BMI and smoking were associated with all MS-positive cases. Findings suggest MS-detected monoclonal gammopathies are associated with a broader range of modifiable risk factors than what has been previously identified. This trial was registered at www.clinicaltrials.gov as #NCT03689595. (© 2024 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.) |
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معلومات مُعتمدة: | F32 CA220859 United States CA NCI NIH HHS; K22 CA251648 United States CA NCI NIH HHS |
سلسلة جزيئية: | ClinicalTrials.gov NCT03689595 |
تواريخ الأحداث: | Date Created: 20240111 Date Completed: 20240401 Latest Revision: 20240607 |
رمز التحديث: | 20240607 |
مُعرف محوري في PubMed: | PMC10997907 |
DOI: | 10.1182/bloodadvances.2023010843 |
PMID: | 38212245 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2473-9537 |
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DOI: | 10.1182/bloodadvances.2023010843 |