دورية أكاديمية

Malignant catarrhal fever in a goat: manifestation of virus-induced erythema multiforme.

التفاصيل البيبلوغرافية
العنوان: Malignant catarrhal fever in a goat: manifestation of virus-induced erythema multiforme.
المؤلفون: Makoni GM; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Gerspach C; Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Fischer N; Dermatology Unit, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Rosato G; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Fabian R; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Grest P; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland., Kipar A; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. (Makoni, Rosato, Fabian, Grest, Kipar).
المصدر: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2024 Mar; Vol. 36 (2), pp. 243-247. Date of Electronic Publication: 2024 Jan 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 9011490 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-4936 (Electronic) Linking ISSN: 10406387 NLM ISO Abbreviation: J Vet Diagn Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011-: Thousand Oaks, CA : Sage
Original Publication: 1989-2004 : Columbia, MO : American Association of Veterinary Laboratory Diagnosticians
مواضيع طبية MeSH: Malignant Catarrh*/diagnosis , Erythema Multiforme*/diagnosis , Erythema Multiforme*/veterinary , Gammaherpesvirinae*/genetics , Cattle Diseases* , Goat Diseases*/diagnosis , Sheep Diseases*/pathology, Female ; Cattle ; Animals ; Sheep ; Goats ; Endothelial Cells/pathology ; RNA, Messenger
مستخلص: Malignant catarrhal fever (MCF), caused by ovine herpesvirus 2 (OvHV2; Orthoherpesviridae , Macavirus ovinegamma2 ), has sheep as natural hosts. OvHV2 is an important macavirus globally that induces fatal disease in dead-end hosts. Goats, which can be infected subclinically with OvHV2, rarely develop MCF. A 28-wk-old female goat was presented with fever and multifocal crusty skin lesions. Histologic examination of a skin biopsy suggested erythema multiforme (EM), with pyoderma and dermal vasculitis. The doe was euthanized and subjected to postmortem and histologic examination. MCF was suspected and PCR assays for macaviruses were performed, followed by immunohistochemistry (IHC) for OvHV2 latency-associated nuclear antigen (oLANA), RNA in situ hybridization for Ov2.5 mRNA, and IHC to characterize infiltrating leukocytes. The main postmortem finding was severe multifocal ulcerative dermatitis with macrophage- and T cell-mediated arteritis. The latter was also detected in kidney, spleen, heart, and intestinal wall. The PCR assay detected high loads of OvHV2 in tissues. OvHV2 oLANA and Ov2.5 mRNA were expressed within the lesions in leukocytes, endothelial cells, fibroblasts, and/or keratinocytes. Our case confirms that MCF can initially manifest clinically as a skin disease in goats and as EM with confirmed viral etiology.
Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: arteritis; erythema multiforme; goats; malignant catarrhal fever; ovine herpesvirus 2; ulcerative dermatitis
المشرفين على المادة: 0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20240111 Date Completed: 20240312 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC10929642
DOI: 10.1177/10406387231224906
PMID: 38212885
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-4936
DOI:10.1177/10406387231224906