دورية أكاديمية
أعرض في EDS

3D printed bioabsorbable composite scaffolds of poly (lactic acid)-tricalcium phosphate-ceria with osteogenic property for bone regeneration.

التفاصيل البيبلوغرافية
العنوان: 3D printed bioabsorbable composite scaffolds of poly (lactic acid)-tricalcium phosphate-ceria with osteogenic property for bone regeneration.
المؤلفون: Harb SV; Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil.; Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA., Kolanthai E; Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA., Pugazhendhi AS; Biionix Cluster, College of Medicine, University of Central Florida, Orlando, FL, USA., Beatrice CAG; Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil., Pinto LA; Graduate Program in Materials Science and Engineering, Department of Materials Engineering (DEMa), Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil., Neal CJ; Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA., Backes EH; Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil., Nunes ACC; Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil., Selistre-de-Araújo HS; Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil., Costa LC; Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil., Coathup MJ; Biionix Cluster, College of Medicine, University of Central Florida, Orlando, FL, USA., Seal S; Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA.; Biionix Cluster, College of Medicine, University of Central Florida, Orlando, FL, USA., Pessan LA; Department of Materials Engineering (DEMa), Federal University of Sao Carlos (UFSCar), São Carlos, SP, Brazil.
المصدر: Biomaterials and biosystems [Biomater Biosyst] 2023 Dec 18; Vol. 13, pp. 100086. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918250307706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-5344 (Electronic) Linking ISSN: 26665344 NLM ISO Abbreviation: Biomater Biosyst Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Elsevier Ltd., [2021]-
مستخلص: The fabrication of customized implants by additive manufacturing has allowed continued development of the personalized medicine field. Herein, a 3D-printed bioabsorbable poly (lactic acid) (PLA)- β-tricalcium phosphate (TCP) (10 wt %) composite has been modified with CeO 2 nanoparticles (CeNPs) (1, 5 and 10 wt %) for bone repair. The filaments were prepared by melt extrusion and used to print porous scaffolds. The nanocomposite scaffolds possessed precise structure with fine print resolution, a homogenous distribution of TCP and CeNP components, and mechanical properties appropriate for bone tissue engineering applications. Cell proliferation assays using osteoblast cultures confirmed the cytocompatibility of the composites. In addition, the presence of CeNPs enhanced the proliferation and differentiation of mesenchymal stem cells; thereby, increasing alkaline phosphatase (ALP) activity, calcium deposition and bone-related gene expression. Results from this study have shown that the 3D printed PLA-TCP-10%CeO 2 composite scaffold could be used as an alternative polymeric implant for bone tissue engineering applications: avoiding additional/revision surgeries and accelerating the regenerative process.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors. Published by Elsevier Ltd.)
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فهرسة مساهمة: Keywords: Additive manufacturing; Biomaterial; Bone tissue engineering; Ceria nanoparticle; Polymer-matrix composites
تواريخ الأحداث: Date Created: 20240112 Latest Revision: 20240113
رمز التحديث: 20240113
مُعرف محوري في PubMed: PMC10776431
DOI: 10.1016/j.bbiosy.2023.100086
PMID: 38213985
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-5344
DOI:10.1016/j.bbiosy.2023.100086