دورية أكاديمية
أعرض في EDS

Immunohistochemical evaluation of keratins and involucrin in differentiating between palmoplantar pustulosis and pompholyx.

التفاصيل البيبلوغرافية
العنوان: Immunohistochemical evaluation of keratins and involucrin in differentiating between palmoplantar pustulosis and pompholyx.
المؤلفون: Oh DY; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea., Kim SJ; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea., Jang YJ; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea., Park EJ; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea., Kim KJ; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea., Kim KH; Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
المصدر: International journal of dermatology [Int J Dermatol] 2024 Jun; Vol. 63 (6), pp. 780-786. Date of Electronic Publication: 2024 Jan 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Science
Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Protein Precursors*/metabolism , Protein Precursors*/analysis , Psoriasis*/metabolism , Psoriasis*/pathology , Psoriasis*/diagnosis , Immunohistochemistry* , Keratins*/metabolism , Keratins*/analysis, Humans ; Male ; Female ; Middle Aged ; Adult ; Diagnosis, Differential ; Aged ; Young Adult ; Eczema, Dyshidrotic/diagnosis ; Eczema, Dyshidrotic/metabolism ; Eczema, Dyshidrotic/pathology ; Biopsy ; Adolescent ; Skin/pathology ; Skin/metabolism ; Keratin-9/metabolism ; Keratin-9/analysis ; Keratin-14/metabolism ; Keratin-14/analysis
مستخلص: Background: Palmoplantar pustulosis (PPP) and pompholyx are chronic diseases characterized by pustules and vesicles on the palms and soles. These disorders often have similar clinicopathological features, which lead to diagnostic difficulties. We aimed to investigate the expression patterns of keratins and involucrin in PPP and pompholyx using immunohistochemical staining.
Methods: Skin biopsies from patients with PPP (n = 40) and pompholyx (n = 22) were immunohistochemically analyzed for Keratin 5, 9, 14, and involucrin expression.
Results: K5 expression was higher in PPP than in pompholyx, with diffusely positive expression in the basal, spinous, and granular layers. K14 expression did not differ between groups. K9 expression was observed near the pompholyx vesicle (P = 0.014) and stratum spinosum (P < 0.001) but was almost absent around PPP pustules. Involucrin expression was diffused around the PPP pustules and partially around the pompholyx vesicles, but without statistical significance (P = 0.123). Involucrin expression was elevated in the basal layer of the PPP compared with that in the pompholyx (P = 0.023).
Conclusion: PPP and pompholyx exhibited distinctive differentiation in the expression of K5, K9, and involucrin.
(© 2024 the International Society of Dermatology.)
References: Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G. A 3‐year causative study of pompholyx in 120 patients. Arch Dermatol. 2007;143:1504–1508.
Jain VK, Aggarwal K, Passi S, Gupta S. Role of contact allergens in pompholyx. J Dermatol. 2004;31:188–193.
Masuda‐Kuroki K, Murakami M, Kishibe M, Kobayashi S, Okubo Y, Yamamoto T, et al. Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx. J Dermatol. 2019;46:399–408.
Yoon SY, Park HS, Lee JH, Cho S. Histological differentiation between palmoplantar pustulosis and pompholyx. J Eur Acad Dermatol Venereol. 2013a;27:889–893.
Kim DY, Kim JY, Kim TG, Kwon JE, Sohn H, Park J, et al. A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx. J Eur Acad Dermatol Venereol. 2013;27:1559–1565.
Yoon SY, Park HS, Yoon HS, Chung JH, Cho S. Utility of epithelial membrane antigen immunostaining in the differentiation between palmoplantar pustulosis and pompholyx. J Eur Acad Dermatol Venereol. 2013b;27:1054–1056.
Fu DJ, Thomson C, Lunny DP, Dopping‐Hepenstal PJ, McGrath JA, Smith FJD, et al. Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis. J Invest Dermatol. 2014;134:754–763.
Fuchs E, Green H. Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell. 1980;19:1033–1042.
Ortiz‐Lopez LI, Choudhary V, Bollag WB. Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders. Psoriasis (Auckl). 2022;12:73–87.
Elango T, Sun J, Zhu C, Zhou F, Zhang Y, Sun L, et al. Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity. Hum Genomics. 2018;12:27.
Wei X, Fricker K, Enk AH, Hadaschik EN. Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases. Int J Dermatol. 2016;55:620–628.
Watt FM. Involucrin and other markers of keratinocyte terminal differentiation. J Invest Dermatol. 1983;81(1 Suppl):100s–103s.
Kim BE, Leung DY, Boguniewicz M, Howell MD. Loricrin and involucrin expression is down‐regulated by Th2 cytokines through STAT‐6. Clin Immunol. 2008;126:332–337.
Chen JQ, Man XY, Li W, Zhou J, Landeck L, Cai SQ, et al. Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK‐3β. Cell Biochem Biophys. 2013;66:523–528.
Yamamoto T. Similarity and difference between palmoplantar pustulosis and pustular psoriasis. J Dermatol. 2021;48:750–760.
Omary MB, Coulombe PA, McLean WH. Intermediate filament proteins and their associated diseases. N Engl J Med. 2004;351:2087–2100.
Lane EB, McLean WH. Keratins and skin disorders. J Pathol. 2004;204:355–366.
Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem Cell Biol. 2008;129:705–733.
Leung DYM, Calatroni A, Zaramela LS, LeBeau PK, Dyjack N, Brar K, et al. The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype. Sci Transl Med. 2019;11:eaav2685.
Alam H, Sehgal L, Kundu ST, Dalal SN, Vaidya MM. Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells. Mol Biol Cell. 2011;22:4068–4078.
Guo Y, Redmond CJ, Leacock KA, Brovkina MV, Ji S, Jaskula‐Ranga V, et al. Keratin 14‐dependent disulfides regulate epidermal homeostasis and barrier function via 14‐3‐3σ and YAP1. Elife. 2020;9:e53165.
Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi OS, et al. To control site‐specific skin gene expression, autocrine mimics paracrine canonical wnt signaling and is activated ectopically in skin disease. Am J Pathol. 2016;186:1140–1150.
Görmar FE, Bernd A, Bereiter‐Hahn J, Holzmann H. Mechanical stimulation enhances human keratinocyte differentiation in culture: induction of cytokeratin 9 synthesis. In: Bernd A, Bereiter‐Hahn J, Hevert F, Holzmann H, editors. Cell and tissue culture models in dermatological research. Berlin, Heidelberg: Springer; 1993.
Kippenberger S, Bernd A, Loitsch S, Guschel M, Muller J, Bereiter‐Hahn J, et al. Signaling of mechanical stretch in human keratinocytes via MAP kinases. J Invest Dermatol. 2000;114:408–412.
Eckert RL, Yaffe MB, Crish JF, Murthy S, Rorke EA, Welter JF. Involucrin—structure and role in envelope assembly. J Invest Dermatol. 1993;100:613–617.
Oddoze L, Témime P. Dyshidrosis and atopy. 2nd note: atopic component in dyshidrosis. Bull Soc Fr Dermatol Syphiligr. 1968;75:378–380.
Waldman RA, DeWane ME, Sloan B, Grant‐Kels JM, Lu J. Dupilumab for the treatment of dyshidrotic eczema in 15 consecutive patients. J Am Acad Dermatol. 2020;82:1251–1252.
Weston GK, Hooper J, Strober BE. Dupilumab in the treatment of dyshidrosis: a report of two cases. J Drugs Dermatol. 2018;17:355–356.
Gall RA, Peters JD, Brinker AJ. Two cases of recalcitrant dyshidrotic eczema treated with dupilumab. J Drugs Dermatol. 2021;20:558–559.
Weins AB, Biedermann T, Eyerich K, Moeckel S, Schnopp C. Successful treatment of recalcitrant dyshidrotic eczema with dupilumab in a child. J Dtsch Dermatol Ges. 2019;17:1165–1167.
المشرفين على المادة: 60108-77-2 (involucrin)
0 (Protein Precursors)
68238-35-7 (Keratins)
0 (Keratin-9)
0 (Keratin-14)
تواريخ الأحداث: Date Created: 20240112 Date Completed: 20240524 Latest Revision: 20240524
رمز التحديث: 20240525
DOI: 10.1111/ijd.17018
PMID: 38214207
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-4632
DOI:10.1111/ijd.17018