دورية أكاديمية
NLRP3 regulates CIITA/MHC II axis and interferon-γ-inducible chemokines in Malassezia globosa-infected keratinocytes.
| العنوان: | NLRP3 regulates CIITA/MHC II axis and interferon-γ-inducible chemokines in Malassezia globosa-infected keratinocytes. |
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| المؤلفون: | Luo Y; Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Tang JF; Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Gao FF; Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Quan JH; Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Ma CT; Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Li SJ; Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Fan YM; Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.; Dermatology, Plastic and Cosmetic Surgery Center, First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China. |
| المصدر: | Mycoses [Mycoses] 2024 Jan; Vol. 67 (1), pp. e13680. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Grosse Verlag Country of Publication: Germany NLM ID: 8805008 Publication Model: Print Cited Medium: Internet ISSN: 1439-0507 (Electronic) Linking ISSN: 09337407 NLM ISO Abbreviation: Mycoses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Grosse Verlag, [1988?- |
| مواضيع طبية MeSH: | Malassezia* , Chemokines, C* , Folliculitis*, Humans ; Mice ; Animals ; Interferon-gamma ; Interferons ; Histocompatibility Antigens Class II/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Inflammasomes ; Promoter Regions, Genetic ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Chemokines/genetics ; Keratinocytes |
| مستخلص: | CIITA, a member of NOD-like receptor (NLR) family, is the major MHC II trans-activator and mediator of Th1 immunity, but its function and interaction with NLRP3 have been little studied. We found activation of NLRP3 inflammasome, increased expression of CIITA, CBP, pSTAT1, STAT1, MHC II, IFN-γ and IFN-γ-inducible chemokines (CCL1 and CXCL8), and colocalisation of NLRP3 with CIITA in Malassezia folliculitis lesions, Malassezia globosa-infected HaCaT cells and mouse skin. CoIP with anti-CIITA or anti-NLRP3 antibody pulled down NLRP3 or both CIITA and ASC. NLRP3 silencing or knockout caused CIITA downexpression and their colocalisation disappearance in HaCaT cells and mouse skin of Nlrp3 -/- mice, while CIITA knockdown had no effect on NLRP3, ASC, IL-1β and IL-18 expression. NLRP3 inflammasome inhibitors and knockdown significantly suppressed IFN-γ, CCL1, CXCL8 and CXCL10 levels in M. globosa-infected HaCaT cells. CCL1 and CXCL8 expression was elevated in Malassezia folliculitis lesions and reduced in Nlrp3 -/- mice. These results demonstrate that M. globosa can activate NLRP3 inflammasome, CIITA/MHC II signalling and IFN-γ-inducible chemokines in human keratinocytes and mouse skin. NLRP3 may regulate CIITA by their binding and trigger Th1 immunity by secreting CCL1 and CXCL8/IL-8, contributing to the pathogenesis of Malassezia-associated skin diseases. (© 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 4SG21277P Discipline Construction Project of Guangdong Medical University; 81673071 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Malassezia; CIITA; HaCaT cell; MHC II; NLRP3 inflammasome; mice |
| المشرفين على المادة: | 82115-62-6 (Interferon-gamma) 9008-11-1 (Interferons) 0 (Histocompatibility Antigens Class II) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (Inflammasomes) 0 (Chemokines, C) 0 (Trans-Activators) 0 (Chemokines) |
| SCR Organism: | Malassezia globosa |
| تواريخ الأحداث: | Date Created: 20240112 Date Completed: 20240115 Latest Revision: 20240129 |
| رمز التحديث: | 20240129 |
| DOI: | 10.1111/myc.13680 |
| PMID: | 38214420 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1439-0507 |
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| DOI: | 10.1111/myc.13680 |