دورية أكاديمية
The Prognostic Value of Alpha-Fetoprotein Ratio in Patients With Resectable Alpha-Fetoprotein-Negative Hepatocellular Carcinoma.
| العنوان: | The Prognostic Value of Alpha-Fetoprotein Ratio in Patients With Resectable Alpha-Fetoprotein-Negative Hepatocellular Carcinoma. |
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| المؤلفون: | Sun LY; Second Department of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Cen WJ; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China., Zeng XX; Second Department of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Zhong YY; Department of Postdoctoral Workstation, HuaBo Biological Pharmaceutic Research Institute, Guangzhou, Guangdong, China., Deng L; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China., Yang JJ; Department of Oncology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China., Li M; Medical Research Center, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China., Wang F; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. |
| المصدر: | The American surgeon [Am Surg] 2024 Jun; Vol. 90 (6), pp. 1240-1249. Date of Electronic Publication: 2024 Jan 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications in association with Southeastern Surgical Congress Country of Publication: United States NLM ID: 0370522 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-9823 (Electronic) Linking ISSN: 00031348 NLM ISO Abbreviation: Am Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Thousand Oaks, CA] : SAGE Publications in association with Southeastern Surgical Congress Original Publication: Atlanta Ga : Southeastern Surgical Congress |
| مواضيع طبية MeSH: | alpha-Fetoproteins*/metabolism , alpha-Fetoproteins*/analysis , Carcinoma, Hepatocellular*/surgery , Carcinoma, Hepatocellular*/mortality , Carcinoma, Hepatocellular*/blood , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/surgery , Liver Neoplasms*/mortality , Liver Neoplasms*/blood , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , Hepatectomy*, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Prognosis ; Aged ; Adult ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/metabolism ; Disease-Free Survival ; Predictive Value of Tests ; Immunohistochemistry |
| مستخلص: | Purpose: This study aimed to investigate the prognostic value of alpha-fetoprotein (AFP) ratio in patients with AFP-negative hepatocellular carcinoma (HCC). Patients and Methods: We retrospectively analyzed 600 AFP-negative HCC patients who underwent hepatectomy. The AFP ratio was calculated as the ratio of AFP level 1 week before surgery to the level 20-40 days after hepatectomy. Immunohistochemistry assay was used to assess protein expression in HCC tissue. The primary outcome measures were overall survival (OS) and disease-free survival (DFS). Results: The study found that a cutoff value of 1.6 ng/ml for AFP ratio, determined using X-tile software, was optimal for predicting prognosis. Patients with a high AFP ratio had a worse prognosis compare to those with a low AFP ratio (DFS, P = .026; OS, P = .034). Patients with a high AFP ratio had a worse prognosis compared to those with a low AFP ratio. Multivariate analysis revealed that AFP ratio >1.6, negative HepPar-1 expression, and vascular invasion were independent predictors of both DFS and OS. Vascular invasion had a higher area under the curve (AUC) than AFP ratio and HepPar-1 expression in predicting recurrence and death. The combination of AFP ratio, HepPar-1 expression, and vascular invasion provided better predictive accuracy for DFS and OS. Conclusion: The AFP ratio is a potential prognostic marker for AFP-negative HCC patients after hepatectomy. Combining the analysis of AFP ratio with HepPar-1 expression and vascular invasion can enhance the accuracy of predicting prognosis in these patients. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: All methods in this research were carried out in accordance with relevant guidelines and regulations. |
| فهرسة مساهمة: | Keywords: alpha-fetoprotein ratio; hepatocellular carcinoma; hepatocyte paraffin-1; prognosis; vascular invasion |
| تواريخ الأحداث: | Date Created: 20240112 Date Completed: 20240516 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.1177/00031348241227202 |
| PMID: | 38214585 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1555-9823 |
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| DOI: | 10.1177/00031348241227202 |