Screening of novel biomarkers for acute kidney transplant rejection using DIA-MS based proteomics.

التفاصيل البيبلوغرافية
العنوان:	Screening of novel biomarkers for acute kidney transplant rejection using DIA-MS based proteomics.
المؤلفون:	Wang C; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Feng G; Department of Kidney Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Zhao J; Department of Kidney Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Xu Y; Department of Kidney Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Li Y; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Wang L; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Wang M; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Liu M; The First Central Clinical School, Tianjin Medical University, Tianjin, China., Wang Y; The First Central Clinical School, Tianjin Medical University, Tianjin, China., Mu H; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China., Zhou C; Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
المصدر:	Proteomics. Clinical applications [Proteomics Clin Appl] 2024 May; Vol. 18 (3), pp. e2300047. Date of Electronic Publication: 2024 Jan 12.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101298608 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1862-8354 (Electronic) Linking ISSN: 18628346 NLM ISO Abbreviation: Proteomics Clin Appl Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Weinheim : Wiley-VCH, c2007-
مواضيع طبية MeSH:	Kidney Transplantation/adverse effects , Graft Rejection/blood , Graft Rejection/diagnosis , Biomarkers/blood , Proteomics*/methods, Humans ; Male ; Female ; Adult ; Middle Aged ; Mass Spectrometry ; Acute Disease ; Serum Amyloid A Protein/metabolism ; Serum Amyloid A Protein/analysis
مستخلص:	Background: Kidney transplantation is the preferred treatment for patients with end-stage renal disease. However, acute rejection poses a threat to the graft long-term survival. The aim of this study was to identify novel biomarkers to detect acute kidney transplant rejection. Methods: The serum proteomic profiling of kidney transplant patients with T cell-mediated acute rejection (TCMR) and stable allograft function (STA) was analyzed using data-independent acquisition mass spectrometry (DIA-MS). The differentially expressed proteins (DEPs) of interest were further verified by enzyme-linked immunosorbent assay (ELISA). Results: A total of 131 DEPs were identified between STA and TCMR patients, 114 DEPs were identified between mild and severe TCMR patients. The verification results showed that remarkable higher concentrations of serum amyloid A protein 1 (SAA1) and insulin like growth factor binding protein 2 (IGFBP2), and lower fetuin-A (AHSG) concentration were found in TCMR patients when compared with STA patients. We also found higher SAA1 concentration in severe TCMR group when compared with mild TCMR group. The receiver operating characteristics (ROC) analysis further confirmed that combination of SAA1, AHSG, and IGFBP2 had excellent performance in the acute rejection diagnosis. Conclusions: Our data demonstrated that serum SAA1, AHSG, and IGFBP2 could be effective biomarkers for diagnosing acute rejection after kidney transplantation. DIA-MS has great potential in biomarker screening of kidney transplantation. (© 2023 Wiley‐VCH GmbH.)
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معلومات مُعتمدة:	KJ20009 2020 Tianjin Health Science and Technology Project, Science and Technology Talent Cultivation Project; TJYXZDXK-015A Tianjin Key Medical Discipline (Specialty) Construction Project; 21ZXJBSY00040 Tianjin Key Science and Technology Project of Tianjin Science and Technology Bureau
فهرسة مساهمة:	Keywords: DIA‐MS; acute rejection; biomarker; diagnosis; kidney transplantation
تواريخ الأحداث:	Date Created: 20240112 Date Completed: 20240516 Latest Revision: 20240516
رمز التحديث:	20240516
DOI:	10.1002/prca.202300047
PMID:	38215274
قاعدة البيانات:	MEDLINE

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تدمد:	1862-8354
DOI:	10.1002/prca.202300047