دورية أكاديمية

Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii.

التفاصيل البيبلوغرافية
العنوان: Five undescribed aryltetralin lignans with cytotoxic activities from the fruits of Cleistanthus eberhardtii.
المؤلفون: Nguyen LH; Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Hanoi University of Pharmacy, 13 Le Thanh Tong, Hoankiem, Hanoi, Viet Nam., Nguyen TH; Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam., Tran VH; Institute of Drug Quality Control - Ho Chi Minh City, 200 Co Bac Street, Co Giang Ward, District 1, Ho Chi Minh City, Viet Nam., Litaudon M; Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France., Nguyen VT; Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam., Doan TMH; Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: huongdm@imbc.vast.vn., Pham VC; Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: phamvc@imbc.vast.vn.
المصدر: Fitoterapia [Fitoterapia] 2024 Mar; Vol. 173, pp. 105826. Date of Electronic Publication: 2024 Jan 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : [Amsterdam] : Elsevier
Original Publication: Milano : Inverni & Della Beffa S.p.A.
مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Lignans*/pharmacology , Lignans*/chemistry , Antineoplastic Agents* , Malpighiales*, Humans ; Cell Line, Tumor ; Fruit/chemistry ; Molecular Structure
مستخلص: Five undescribed lignans, cleiseberharnins A-D (1-4), cleiseberharside A (5) were isolated from the fruits of Cleistanthus eberhartii (Phyllanthaceae), together with six known aryltetralin lignans, cleistantoxin (6), picroburseranin (7), neocleistantoxin (8), 7-hydroxypicropolygamain (9), cleisindoside D (10), and cleisindoside A (11). Their structures and relative configurations were established by analysis of HRESIMS and NMR data, and quantum chemical calculations of J H,H coupling constants. The absolute configurations of 1-5 were determined by analysis of their experimental CD spectra and comparison with calculated electronic circular dichroism (ECD) spectra. All compounds (1-11) were evaluated for their cytotoxicity against KB, MCF-7, HepG-2, and Lu-1 human cancer cell lines. Among the tested compounds, compounds 6 and 7 showed strong activity against KB, MCF7, HepG2 and Lu-1 cell lines with IC 50 values in the range of 0.02-0.62 μM. Compound 1 showed activity against three cancer cell lines KB, HepG2, and Lu-1 with IC 50 values of 6.98, 7.61 and 11.75 μM, respectively. Compound 2 exhibited a selective inhibition with moderate cytotoxicity against Lu-1 with IC 50 value of 15.30 μM. Compounds 4, 5 and 9 showed moderate activity against the three cancer cell lines with IC 50 values in the range of 8.73-19.70 μM.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Aryltetralin lignan; Cleiseberharnin; Cleistanthus eberhardtii; Cytotoxicity; Phyllanthaceae
المشرفين على المادة: 0 (Antineoplastic Agents, Phytogenic)
0 (Lignans)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20240114 Date Completed: 20240214 Latest Revision: 20240214
رمز التحديث: 20240214
DOI: 10.1016/j.fitote.2024.105826
PMID: 38219842
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6971
DOI:10.1016/j.fitote.2024.105826