دورية أكاديمية
أعرض في EDS

Emotional Distress Predicts Reduced Type 2 Diabetes Treatment Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

التفاصيل البيبلوغرافية
العنوان: Emotional Distress Predicts Reduced Type 2 Diabetes Treatment Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
المؤلفون: Hoogendoorn CJ; Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY., Krause-Steinrauf H; Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Uschner D; Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Wen H; Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Presley CA; General Internal and Preventive Medicine, Department of Medicine, University of Alabama, Birmingham, Birmingham, AL., Legowski EA; Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Naik AD; Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, TX.; University of Texas Health Science Center (UTHealth) School of Public Health, Houston, TX.; Consortium on Aging, University of Texas Health Science Center (UTHealth), Houston, TX., Golden SH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Arends VL; Advanced Research and Diagnostic Laboratory, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN., Brown-Friday J; Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY., Krakoff JA; Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ., Suratt CE; Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD., Waltje AH; University of Michigan, Ann Arbor, MI., Cherrington AL; General Internal and Preventive Medicine, Department of Medicine, University of Alabama, Birmingham, Birmingham, AL., Gonzalez JS; Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.; New York-Regional Center for Diabetes Translation Research, Albert Einstein College of Medicine, Bronx, NY.
مؤلفون مشاركون: GRADE Research Group
المصدر: Diabetes care [Diabetes Care] 2024 Apr 01; Vol. 47 (4), pp. 629-637.
نوع المنشور: Randomized Controlled Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
أسماء مطبوعة: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn.
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Metformin*/therapeutic use , Psychological Distress*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Glucose/therapeutic use ; Medication Adherence/psychology ; Comparative Effectiveness Research
مستخلص: Objective: We examined longitudinal associations between emotional distress (specifically, depressive symptoms and diabetes distress) and medication adherence in Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), a large randomized controlled trial comparing four glucose-lowering medications added to metformin in adults with relatively recent-onset type 2 diabetes mellitus (T2DM).
Research Design and Methods: The Emotional Distress Substudy assessed medication adherence, depressive symptoms, and diabetes distress in 1,739 GRADE participants via self-completed questionnaires administered biannually up to 3 years. We examined baseline depressive symptoms and diabetes distress as predictors of medication adherence over 36 months. Bidirectional visit-to-visit relationships were also examined. Treatment satisfaction, beliefs about medication, diabetes care self-efficacy, and perceived control over diabetes were evaluated as mediators of longitudinal associations.
Results: At baseline, mean ± SD age of participants (56% of whom were White, 17% Hispanic/Latino, 18% Black, and 66% male) was 58.0 ± 10.2 years, diabetes duration 4.2 ± 2.8 years, HbA1c 7.5% ± 0.5%, and medication adherence 89.9% ± 11.1%. Higher baseline depressive symptoms and diabetes distress were independently associated with lower adherence over 36 months (P < 0.001). Higher depressive symptoms and diabetes distress at one visit predicted lower adherence at the subsequent 6-month visit (P < 0.0001) but not vice versa. Treatment assignment did not moderate relationships. Patient-reported concerns about diabetes medications mediated the largest percentage (11.9%-15.5%) of the longitudinal link between emotional distress and adherence.
Conclusions: Depressive symptoms and diabetes distress both predict lower adherence to glucose-lowering medications over time among adults with T2DM. Addressing emotional distress and concerns about anticipated negative effects of taking these treatments may be important to support diabetes treatment adherence.
(© 2024 by the American Diabetes Association.)
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معلومات مُعتمدة: UL1 TR000445 United States TR NCATS NIH HHS; United States HL NHLBI NIH HHS; UL1 TR002529 United States TR NCATS NIH HHS; P30 DK111022 United States DK NIDDK NIH HHS; UL1 TR000439 United States TR NCATS NIH HHS; P30 DK020541 United States DK NIDDK NIH HHS; UL1 TR002378 United States TR NCATS NIH HHS; UM1 TR004528 United States TR NCATS NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS; UL1 TR002345 United States TR NCATS NIH HHS; UL1 TR002548 United States TR NCATS NIH HHS; U34 DK088043 United States DK NIDDK NIH HHS; R01 DK104845 United States DK NIDDK NIH HHS; UL1 TR002537 United States TR NCATS NIH HHS; P30 DK092926 United States DK NIDDK NIH HHS; UL1 TR002535 United States TR NCATS NIH HHS; P30 DK072476 United States DK NIDDK NIH HHS; P30 DK079626 United States DK NIDDK NIH HHS; UL1 TR001409 United States TR NCATS NIH HHS; U01 DK098246 United States DK NIDDK NIH HHS; UL1 TR001449 United States TR NCATS NIH HHS; UL1 TR002489 United States TR NCATS NIH HHS; U54 GM104940 United States GM NIGMS NIH HHS; UL1 TR001108 United States TR NCATS NIH HHS; UL1 TR002243 United States TR NCATS NIH HHS; R01DK104845, U01DK098246, U34DK088043 United States DK NIDDK NIH HHS; P30 DK017047 United States DK NIDDK NIH HHS; United States CC CDC HHS
فهرسة مساهمة: Investigator: JP Crandall; MD McKee; S Behringer-Massera; J Brown-Friday; E Xhori; K Ballentine-Cargill; S Duran; H Estrella; S Gonzalez de la Torre; J Lukin; LS Phillips; E Burgess; D Olson; M Rhee; P Wilson; TS Raines; J Boers; J Costello; M Maher-Albertelli; R Mungara; L Savoye; CA White; C Gullett; L Holloway; F Morehead; S Person; M Sibymon; S Tanukonda; C Adams; A Ross; A Balasubramanyam; R Gaba; E Gonzalez Hattery; A Ideozu; J Jimenez; G Montes; C Wright; P Hollander; E Roe; A Jackson; A Smiley; P Burt; L Estrada; K Chionh; F Ismail-Beigi; C Falck-Ytter; L Sayyed Kassem; A Sood; M Tiktin; T Kulow; C Newman; KA Stancil; B Cramer; J Iacoboni; MV Kononets; C Sanders; L Tucker; A Werner; A Maxwell; G McPhee; C Patel; L Colosimo; A Krol; R Goland; J Pring; L Alfano; P Kringas; C Hausheer; J Tejada; K Gumpel; A Kirpitch; H Schneier; JB Green; H AbouAssi; R Chatterjee; MN Feinglos; J English Jones; SA Khan; JB Kimpel; RP Zimmer; M Furst; BM Satterwhite; CR Thacker; K Evans Kreider; 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المشرفين على المادة: IY9XDZ35W2 (Glucose)
9100L32L2N (Metformin)
تواريخ الأحداث: Date Created: 20240116 Date Completed: 20240327 Latest Revision: 20240420
رمز التحديث: 20240420
مُعرف محوري في PubMed: PMC10973907
DOI: 10.2337/dc23-1401
PMID: 38227900
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-5548
DOI:10.2337/dc23-1401