دورية أكاديمية
Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis.
| العنوان: | Efficacy of Fine-Needle Aspiration Cytology in Diagnosing Secretory Carcinoma of Salivary Gland: A Systematic Review and Meta-Analysis. |
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| المؤلفون: | Kala PS; Department of Pathology, Government Doon Medical College, Dehradun, India., Gupta M; Department of Pathology, Government Doon Medical College, Dehradun, India., Thapliyal N; Department of Pathology, Government Doon Medical College, Dehradun, India. |
| المصدر: | Acta cytologica [Acta Cytol] 2024; Vol. 68 (2), pp. 83-106. Date of Electronic Publication: 2024 Jan 16. |
| نوع المنشور: | Systematic Review; Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0370307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2650 (Electronic) Linking ISSN: 00015547 NLM ISO Abbreviation: Acta Cytol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Basel : Karger Original Publication: Chicago : International Academy of Cytology |
| مواضيع طبية MeSH: | Salivary Gland Neoplasms*/pathology , Salivary Gland Neoplasms*/diagnosis , Salivary Gland Neoplasms*/genetics, Humans ; Biopsy, Fine-Needle/methods ; Female ; Predictive Value of Tests ; Salivary Glands/pathology ; Adult ; Male ; Reproducibility of Results ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Middle Aged ; Carcinoma/pathology ; Carcinoma/diagnosis ; Carcinoma/genetics ; Mammary Analogue Secretory Carcinoma/pathology ; Mammary Analogue Secretory Carcinoma/diagnosis ; Mammary Analogue Secretory Carcinoma/genetics ; Oncogene Proteins, Fusion/genetics ; Young Adult ; Adolescent ; Cytodiagnosis/methods ; Aged ; Diagnosis, Differential ; Child ; Cytology ; ETS Translocation Variant 6 Protein ; Receptor, trkC |
| مستخلص: | Introduction: The diagnosis of salivary gland secretory carcinoma (SC) in fine-needle aspiration specimens is challenging because its low-grade nature makes it difficult to differentiate it from various benign or malignant salivary gland neoplasms. Currently, the gold standard is demonstration of ETV6-NTRK3 fusion gene. However, the decision for ordering this costly molecular testing can be facilitated by the correct recognition of its cytomorphological features. The aim of the review was to determine the accuracy of fine-needle aspiration cytology (FNAC) in diagnosis of salivary gland SC. The secondary objective was to recognize varied cytomorphological patterns, characteristic features of SC and differentiate it from other neoplasms. Methods: PubMed/MEDLINE, Science Direct, Embase, Cochrane review, and PROSPERO databases were searched for studies having the following key search terms: ("secretory carcinoma of salivary gland" OR "mammary analogue secretory carcinoma of salivary gland") AND ("Cytology" OR "Cytological features" OR "aspirate" OR "cytodiagnosis") published in the time frame of 2010 to June 2023. Studies reporting cytological features of the salivary gland tumors which were confirmed/diagnosed as SC on molecular investigation, were included in the systematic review. Finally, seventeen studies reporting a total of 45 cases were included in the metanalysis. Results: The sensitivity of the FNAC in diagnosing SC in salivary gland is 27.7% (95% CI: 16.6-42.5%). The LR+ (positive likelihood ratio) was 0.654 (0.344-1.245), LR- (negative likelihood ratio) was 1.023 (0.538-1.946), and diagnostic odds ratio was 0.421 (0.129-1.374). The molecular testing and/or immunohistochemistry performed on cell block increased the diagnostic accuracy. Conclusion: Recognition of subtle cytomorphological patterns, i.e., papillary formation, clusters, and singly dispersed cells along with presence of fine intracytoplasmic vacuolations were the characteristic findings in majority of cases, confirmed with diagnostic molecular profiling. This may be helpful in identification of this rare entity with limited published literature and help in increasing diagnostic accuracy. (© 2024 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Cytology; Mammary analog secretory carcinoma; Molecular testing; Parotid gland; Salivary gland; Secretory carcinoma |
| المشرفين على المادة: | 0 (ETV6-NTRK3 fusion protein, human) |
| تواريخ الأحداث: | Date Created: 20240116 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1159/000536249 |
| PMID: | 38228123 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1938-2650 |
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| DOI: | 10.1159/000536249 |