دورية أكاديمية
أعرض في EDS

Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis.
المؤلفون: Abdelwahab OA; Medical Research Group of Egypt, Cairo, Egypt. omarabdelwahab.216@azhar.edu.eg.; Faculty of Medicine, Al-Azhar University, Cairo, Egypt. omarabdelwahab.216@azhar.edu.eg., Abdelaziz A; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Diab S; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Ain Shams University, Cairo, Egypt., Khazragy A; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Elboraay T; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Zagazig University, Zagazig, Egypt., Fayad T; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Oral and Dental Medicine, Sinai University, Sinai, Egypt., Diab RA; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Al-Azhar University for Girls, Cairo, Egypt., Negida A; Medical Research Group of Egypt, Cairo, Egypt.; Faculty of Medicine, Zagazig University, Zagazig, Egypt.; School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmount, UK.; Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
المصدر: Irish journal of medical science [Ir J Med Sci] 2024 Jun; Vol. 193 (3), pp. 1621-1639. Date of Electronic Publication: 2024 Jan 17.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Royal Academy of Medicine of Ireland Country of Publication: Ireland NLM ID: 7806864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-4362 (Electronic) Linking ISSN: 00211265 NLM ISO Abbreviation: Ir J Med Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Dublin : Royal Academy of Medicine of Ireland
مواضيع طبية MeSH: Network Meta-Analysis* , Vitamin B 12*/therapeutic use , Vitamin B 12*/administration & dosage , Vitamin B 12 Deficiency*/drug therapy, Humans ; Administration, Oral ; Administration, Sublingual ; Dietary Supplements ; Hemoglobins/analysis ; Hemoglobins/drug effects ; Injections, Intramuscular ; Treatment Outcome
مستخلص: Background: This systematic review and network meta-analysis aimed to evaluate the three different administration routes of vitamin B12: oral, intramuscular (IM), and sublingual (SL) routes.
Methods: We searched four electronic databases (PubMed, Scopus, Web of Science, and Cochrane CENTRAL Register of Controlled Trials). We included only comparative studies. We performed a frequentist network meta-analysis to measure network estimates for the relative outcomes. Moreover, we conducted a pairwise meta-analysis using a random effect model to obtain direct estimates for outcomes. All outcomes were continuous, and the relative treatment effects were pooled as mean difference (MD) with 95% confidence intervals.
Results: Thirteen studies were included in the meta-analysis, with a total of 4275 patients. Regarding increasing vitamin B12 levels, the IM route ranked first, followed by the SL route (MD = 94.09 and 43.31 pg/mL, respectively) compared to the oral route. However, these differences did not reach statistical significance owing to the limited number of studies. Regarding the hemoglobin level, the pooled effect sizes showed no difference between all routes of administration that could reach statistical significance. However, the top two ranked administration routes were the oral route (78.3) and the IM route (49.6).
Conclusion: All IM, oral, and SL routes of administration of vitamin B12 can effectively increase the level of vitamin B12 without significant differences between them, as thought previously. However, the IM route was the top-ranked statistically but without clinical significance. We found no significant difference among studied administrated routes in all other CBC parameters and homocysteine levels.
(© 2024. The Author(s).)
References: Diabetes Metab. 2016 Nov;42(5):316-327. (PMID: 27130885)
Blood. 2008 Sep 15;112(6):2214-21. (PMID: 18606874)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
N Z Med J. 2016 Jun 10;129(1436):67-75. (PMID: 27355231)
Nat Rev Dis Primers. 2020 Jul 9;6(1):56. (PMID: 32647173)
BMJ. 2016 Oct 12;355:i4919. (PMID: 27733354)
N Engl J Med. 2013 Jan 10;368(2):149-60. (PMID: 23301732)
Drug Deliv Transl Res. 2019 Jun;9(3):625-630. (PMID: 30632091)
Ann Surg. 2000 Aug;232(2):199-201. (PMID: 10903597)
Clin Nutr. 2019 Apr;38(2):906-911. (PMID: 29506877)
Blood. 1998 Aug 15;92(4):1191-8. (PMID: 9694707)
Br J Haematol. 2014 Aug;166(4):496-513. (PMID: 24942828)
Hematology. 2021 Dec;26(1):1013-1017. (PMID: 34871525)
Hematology. 2018 Oct;23(9):653-657. (PMID: 29577819)
Br J Clin Pharmacol. 2003 Dec;56(6):635-8. (PMID: 14616423)
Acta Med Scand. 1978;204(1-2):81-4. (PMID: 685735)
Curr Med Sci. 2020 Oct;40(5):801-809. (PMID: 33123894)
Swiss Med Wkly. 2017 Apr 19;147:w14421. (PMID: 28421567)
Clin Ther. 2003 Dec;25(12):3124-34. (PMID: 14749150)
J Pediatr Pharmacol Ther. 2014 Jan;19(1):60-3. (PMID: 24782694)
Annu Rev Med. 2000;51:357-75. (PMID: 10774470)
Am J Clin Nutr. 2018 Jul 1;108(1):6-12. (PMID: 29931179)
Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. (PMID: 29543316)
J Clin Nurs. 2015 Sep;24(17-18):2368-75. (PMID: 25871949)
BMJ Open. 2020 Aug 20;10(8):e033687. (PMID: 32819927)
Clin Ther. 2011 Mar;33(3):358-371.e2. (PMID: 21600388)
Am Fam Physician. 2011 Jun 15;83(12):1425-30. (PMID: 21671542)
Acta Med Scand. 1968 Oct;184(4):247-58. (PMID: 5751528)
Eur J Gen Pract. 2006;12(4):169-73. (PMID: 17127603)
BMJ. 2019 Aug 28;366:l4898. (PMID: 31462531)
Rev Invest Clin. 2020 May 07;72(6):380-385. (PMID: 33053572)
Am Fam Physician. 2017 Sep 15;96(6):384-389. (PMID: 28925645)
Anesth Prog. 1991 Jul-Oct;38(4-5):154-71. (PMID: 1819968)
Res Synth Methods. 2012 Jun;3(2):98-110. (PMID: 26062084)
Exp Gerontol. 2017 Sep;95:136-140. (PMID: 28549839)
PLoS One. 2013 Oct 03;8(10):e76654. (PMID: 24098547)
BMJ. 2014 Sep 04;349:g5226. (PMID: 25189324)
فهرسة مساهمة: Keywords: Administration; Intramuscular; Oral; Sublingual; Vitamin B12
المشرفين على المادة: 0 (Hemoglobins)
P6YC3EG204 (Vitamin B 12)
تواريخ الأحداث: Date Created: 20240117 Date Completed: 20240526 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC11128391
DOI: 10.1007/s11845-023-03602-4
PMID: 38231320
قاعدة البيانات: MEDLINE
الوصف
تدمد:1863-4362
DOI:10.1007/s11845-023-03602-4