دورية أكاديمية
أعرض في EDS

Static magnetic stimulation induces structural plasticity at the axon initial segment of inhibitory cortical neurons.

التفاصيل البيبلوغرافية
العنوان: Static magnetic stimulation induces structural plasticity at the axon initial segment of inhibitory cortical neurons.
المؤلفون: Beros JL; School of Biological Sciences, The University of Western Australia, Crawley, 6009, Australia. jamie.beros@uwa.edu.au.; The Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia. jamie.beros@uwa.edu.au., King ES; The Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia.; School of Biomedical Sciences, The University of Western Australia, Crawley, 6009, Australia., Clarke D; Département de Neurosciences, Université de Montréal, Quebec, H3C 3J7, Canada., Jaeschke-Angi L; School of Biological Sciences, The University of Western Australia, Crawley, 6009, Australia.; The Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia., Rodger J; School of Biological Sciences, The University of Western Australia, Crawley, 6009, Australia.; The Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia., Tang AD; The Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia. adtang.research@gmail.com.; School of Biomedical Sciences, The University of Western Australia, Crawley, 6009, Australia. adtang.research@gmail.com.
المصدر: Scientific reports [Sci Rep] 2024 Jan 17; Vol. 14 (1), pp. 1479. Date of Electronic Publication: 2024 Jan 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Axon Initial Segment*, Animals ; Axons/physiology ; Neurons/physiology ; Action Potentials/physiology ; Neuronal Plasticity/physiology ; Calcium Channels ; Magnetic Phenomena ; Mammals
مستخلص: Static magnetic stimulation (SMS) is a form of non-invasive brain stimulation that alters neural activity and induces neural plasticity that outlasts the period of stimulation. This can modify corticospinal excitability or motor behaviours, suggesting that SMS may alter the intrinsic excitability of neurons. In mammalian neurons, the axon initial segment (AIS) is the site of action potential initiation and undergoes structural plasticity (changes in length and position from the soma) as a homeostatic mechanism to counteract chronic changes in neuronal activity. We investigated whether the chronic application of SMS (6 and 48 h, 0.5 T) induces structural AIS plasticity in postnatally derived primary cortical neurons. Following 6 h of SMS, we observed a shortening in mean AIS length compared to control, that persisted 24 h post stimulation. In contrast, 48 h of SMS induced an immediate distal shift that persisted 24 h post-stimulation. Pharmacological blockade of voltage gated L/T-type calcium channels during stimulation did not prevent SMS-induced AIS structural plasticity. Our findings provide the foundation to expand the use of chronic SMS as a non-invasive method to promote AIS plasticity.
(© 2024. The Author(s).)
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معلومات مُعتمدة: VFA10-20 Raine Medical Research Foundation; RPG06-20 Raine Medical Research Foundation
المشرفين على المادة: 0 (Calcium Channels)
تواريخ الأحداث: Date Created: 20240117 Date Completed: 20240119 Latest Revision: 20240121
رمز التحديث: 20240121
مُعرف محوري في PubMed: PMC10794225
DOI: 10.1038/s41598-024-51845-7
PMID: 38233493
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-51845-7